The Effects of Ferula elaeochytris on the Oxidant/Nitrosative Stress in Experimental Myoglobinuric Acute Renal Failure

Year 2025, Volume: 45 Issue: 3, 231 - 244, 01.09.2025

Meltem Güngör , Serap Yalın , Ebru Ballı , Gulsen Bayrak , Fatma Yıldız , Metin Yıldırım , Athanasia Pavlopoulou , Alexandros G Georgakılas , Gülhan Temel , Ali Erdinç Yalın

https://doi.org/10.52794/hujpharm.1683794

Abstract

Free radicals and nitric oxide play an important role in the pathogenesis of Myoglobinuric Acute Renal Failure (mARF). Herein, we aimed to investigate the effects of Ferula elaeochytris on the oxidative-antioxidant system and nitrosative stress in experimental mARF. In our study, 56 Sprague-Dawley rats, equally divided in seven groups, were used as model organisms of experimentally induced mARF. A disease model of mARF was established with 50% glycerol in all groups except one. Moreover, 40 mg/kg and 80 mg/kg of F. elaeochytris root extract were administered intragastrically before and after model creation. The following were investgated in the kidney tissue: serum urea nitrogen, urea, creatinine, sodium and potassium levels of rats in all groups; urinary urea and creatinine levels; MDA, SOD, GPx, CAT, NO and nitrotyrosine parameters. In addition, histological changes in the kidney were recorder with electron microscopy. Significant changes were observed in the CAT, GPx and MDA values of all groups compared to the control group. Electron microscopy observations also supported these findings. Herein, we provide evidence regarding the limited protective and curative effects of Ferula elaeochytris on mARF through reduction of the oxidant/nitrosative stress.

Keywords

Ferula elaeochytris , myoglobinuric acute renal failure , nitrosative stress , oxidative stress.

Project Number

TK-TP3-12

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