Effect of Different Doses of Tolfenamic Acid Administration to Ducks on Biochemical Parameters

Abstract

The objective of this study is to reveal the changes in biochemical parameters after intravenous administration of different doses of tolfenamic acid to ducks. A total of 18 healthy ducks were divided into 3 dose groups. Tolfenamic acid was administered intravenously to ducks at doses of 2 mg/kg, 4 mg/kg and 8 mg/kg. Blood samples were taken from the brachial vein at 0, 12, 24 and 48 hours. Creatinine, urea, total protein, albumin, cholesterol, triglyceride, gamma glutamyltransferase (GGT), alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were determined in the autoanalyzer from the serum obtained from blood samples. Intravenous administration of increasing doses of tolfenamic acid was well tolerated by the ducks. Administration of tolfenamic acid at different doses did not cause any difference in AST, ALP, GGT, albumin, total protein, cholesterol, urea and creatinine values (p>0.05). All doses of tolfenamic acid caused significant changes in ALT and triglyceride levels (p < 0.05). As a result, tolfenamic acid was generally well tolerated in ducks. However, the safety of tolfenamic acid after application at different doses needs to be demonstrated with hematological, molecular and histopathological results.

Keywords

• Ascending dose
• Biochemical parameters
• Duck
• Tolfenamic acid

Ördeklere Farklı Dozlarda Tolfenamik Asit Uygulamasının Biyokimyasal Parametrelere Etkisi

Abstract

Bu çalışmanın amacı ördeklere tolfenamik asitin farklı dozlarda damar içi yolla uygulaması sonrası biyokimyasal parametrelerdeki değişimi ortaya koymaktır. Toplam 18 adet sağlıklı ördek 3 doz grubuna ayrıldı. Tolfenamik asit ördeklere 2 mg/kg, 4 mg/kg ve 8 mg/kg dozda damar içi yolla uygulandı. Kan örnekleri 0., 12., 24. ve 48. saatlerde brachial venden alındı. Kan örneklerinden elde edilen serumlardan kreatinin, üre, total protein, albümin, kolesterol, trigliserid, gamma glutamiltransferaz (GGT), alkalen fosfataz (ALP), alanin aminotransferaz (ALT) ve aspartat aminotransferaz (AST) seviyeleri otoanalizör cihazında belirlendi. Tolfenamik asitin artan dozlarda damar içi uygulaması ördekler tarafından iyi tolere edildi. Tolfenamik asitin farklı dozlardan uygulaması AST, ALP, GGT, albümin, total protein, kolesterol, üre ve kreatinin değerlerinde herhangi bir farklılığa neden olmadı (p>0.05). Tolfenamik asitin tüm dozları ALT ve trigliserid düzeylerinde önemli değişikliklere neden oldu (p <0.05). Sonuç olarak tolfenamik asit ördeklerde genel olarak iyi tolere edildi. Ancak, tolfenamik asitin farklı dozlarda uygulamalarının ardından güvenilirliğinin hematolojik, moleküler ve histopatolojik sonuçlarla ortaya konulmasına ihtiyaç vardır.

Keywords

• Artan doz
• biyokimyasal parametreler
• ördek
• tolfenamik asit

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