A Bibliometric Analysis of Thromboelastography in Veterinary Clinical Use

Abstract

The evaluation of coagulation with thromboelastography (TEG) has been of high interest for the last two decades in veterinary medicine. The main cause is the ability to detect hypo-, normo- and hypercoagulative states in a single TEG analysis. In clinical veterinary medicine, the importance of coagulation in terms of course and outcome in many diseases had been realized through research over time. TEG studies had gained importance as traditional coagulation tests were inadequate, especially in cases complicated with hypercoagulation. The bibliometric analysis determined topics, researchers and countries of studies in veterinary clinical use of TEG. According to the Web of Science database, a total of 371 documents in this research field were identified between 1998 and 2023. In 2012, with 39 articles, the highest number of studies were published. The most relevant author was Kristensen A.T. with 39 articles. In the list of corresponding authors’ countries, the first country with 189 authors was determined as the USA. Trend topics and their distribution over time have shown that dogs were the most studied animal species in this field. A high number of studies on the topic hypercoagulability and immune-mediated hemolytic anemia were detected, but in the last 3 years new topics like antithrombotics and rational use were involved. The bibliometric analysis carried out showed the changes over time and the currentness of the subject. The results of the present study could be used in planning future studies in the field of veterinary clinical use of TEG.

Keywords

• Bibliometrics
• Clinic
• Thromboelastography
• Veterinary

Veteriner Klinik Kullanımında Tromboelastografinin Bibliyometrik Analizi

Abstract

Thromboelastografi (TEG) ile pıhtılaşmanın değerlendirilmesi, son yirmi yıl içerisinde veteriner hekimlikte büyük ilgi görmüştür. Bu ilginin temel nedeni, tek bir TEG analizinde hipo-, normo- ve hiperkoagülatif durumları tespit edebilmesidir. Klinik veteriner hekimliği açısından, birçok hastalığın seyri ve sonucu üzerinde pıhtılaşmanın önemi, zamanla yapılan araştırmalarla fark edilmiştir. Özellikle hiperkoagülasyonla komplike olan durumlarda, geleneksel pıhtılaşma testlerinin yetersiz olduğu durumlarda, TEG çalışmaları önem kazanmıştır. Bibliyometrik analiz, TEG'nin veteriner hekimliği klinik kullanımı alanındaki konuları, araştırmacıları ve ülkeler hakkında bilgi vermiştir. Web of Science veritabanına göre, 1998 ile 2023 arasında bu araştırma alanında toplam 371 belge tanımlanmıştır. İki bin on iki yılında, 39 makale ile en yüksek sayıda çalışma yayımlanmıştır. Yazarlardan Kristensen A.T. 39 makale ile bu alanda en yüksek sayıda araştırmayla karşımıza çıkmıştır. Sorumlu yazarların ülkeleri sıralamasında 189 yazar ile birinci sırada yer alan ülke ABD olarak belirlenmiştir. Öne çıkan konular ve bunların zaman içindeki dağılımları, köpeklerin bu alandaki en çok çalışılan hayvan türü olduğunu göstermiştir. Hiperkoagulabilite ve immün ilişkili hemolitik anemi konusunda çok sayıda çalışma saptanmasına rağmen, son 3 yılda antitrombotikler ve rasyonel kullanım gibi yeni konular da dahil edildiği tespit edilmiştir. Yapılan bibliyometrik analiz, bu alanda zaman içerisindeki değişiklikleri ve konunun güncelliğini göstermiştir. Bu çalışma, TEG’nin veteriner klinik kullanımına dair araştırmalarının gelişim ve değişiminin ve bu konuyla ilgili gelecekteki araştırmaları yönlendirmeye yardımcı olacak kapsamlı bir bibliyometrik analizini göstermektedir.

Keywords

• Biblyometri
• Klinik
• Tromboelastografi
• Veteriner

References

1. Altay Y, Kaplan S, 2023: Bibliometric Analyzes of Some Major Effect Genes Associated with Meat Yield Traits in Livestock. Selcuk J Agr Food Sci, 37 (3), 608-617.
2. Alwood AJ, Downend AB, Slensky KA, et al., 2004: Resident forum abstracts: evaluation of thrombelastography (TEG) in normal cats. J Vet Emerg Crit Care, 14, 1–17.
3. Anonim (1): https://www.webofscience.com/wos/woscc/basic-search, Access date; 02.10.2023.
4. Aria M, Cuccurullo C, 2017: Bibliometrix: An R-tool for comprehensive science mapping analysis. J Informetr, 11 (4), 959-975.
5. Bassan T, Pastor J, Agulla B, et al., 2023: Reference Range of Kaolin-Activated Thromboelastography (TEG) Values in Healthy Pet Rabbits (Oryctolagus cuniculus). Animals, 13 (14), 2389.
6. Bauer N, Eralp O, Moritz A, 2009: Establishment of reference intervals for kaolin-activated thromboelastography in dogs including an assessment of the effects of sex and anticoagulant use. J Vet Diagn Invest, 21 (5), 641–648.
7. Blois SL, Holowaychuk MK, Wood RD, 2015: Evaluation of thromboelastography in two factor XII-deficient cats. JFMS Open Rep, 1 (1), 2055116915585025.
8. Borrelli A, Botto A, Maurella C, et al., 2017: Thromboelastometric assessment of hemostasis in newborn Piemontese calves. J Vet Diagn Invest, 29 (3), 293–297.

9. Cam B, Sagdilek E, Yildirim N, et al., 2015: Cytidine 5'-diphosphocholine differentially affects hemostatic parameters in diverse conditions in rats: an investigation via thromboelastography. Shock, 43 (4), 387–394.
10. Corda F, Ballocco I, Corda A, et al., 2023: Coagulation Abnormalities in Dogs with Parvoviral Enteritis. Vet Sci,10 (1), 41.
11. Cruz MV, Luker JN, Carney BC, et al., 2017: Reference ranges for rotational thromboelastometry in male Sprague Dawley rats. Thrombosis J, 28, 15-31.
12. Dixon A, Hall EJ, Adamantos S, et al., 2021: Hypercoagulability in dogs with chronic enteropathy and association with serum albumin concentration. J Vet Intern Med, 35 (2), 860–866.
13. Döderlein E, Mischke R, 2015: Reference intervals for thromboelastometry with the ROTEM delta in cats. Res Vet Sci, 100, 271–276.
14. Engelen C, Moritz A, Barthel F, et al., 2017: Preliminary reference intervals and the impact of citrate storage time for thrombelastography in cats including delta and the velocity curve. BMC Vet Res, 13 (1), 366.
15. Ergin M, Albayrak Delialioğlu R, Altay Y, Koşkan Ö, 2023a: Bibliometric analysis of the studies determined by the monte carlo simulation technique of the power of the test. BSJ Eng Sci, 6(4), 414-420.
16. Ergin M, Albayrak Delialioglu R, Altay Y, Koşkan Ö, 2023b: Bibliometric Analysis of Lactation Curves in Livestock. Turk Tarim Doga Bilim Derg, 10 (4), 1009-1016.
17. Fenty RK, Delaforcade AM, Shaw SE, et al., 2011: Identification of hypercoagulability in dogs with primary immune-mediated hemolytic anemia by means of thromboelastography. J Am Vet Med Assoc, 238 (4), 463–467.
18. Goggs R, Wiinberg B, Kjelgaard-Hansen M, et al., 2012: Serial assessment of the coagulation status of dogs with immune-mediated haemolytic anaemia using thromboelastography. Vet J, 191 (3), 347–353.
19. Han HJ, Kim JH, 2022: Correlation Between D-Dimer Concentrations and Thromboelastography in Dogs With Critical Illness: A Retrospective, Cross-Sectional Study. Front Vet Sci, 14 (9), 844022.
20. Hartert H, 1948: Blood clotting studies with thrombus stressography; a new investigation procedure. Klin Wochenschr, 26, 577–583.
21. Honoré ML, Pihl TH, Nielsen LN, 2021: A pilot study evaluating the Calibrated Automated Thrombogram assay and application of plasma-thromboelastography for detection of hemostatic aberrations in horses with gastrointestinal disease. BMC Vet Res, 17 (1), 346.
22. Johnson CA Jr, Woolley JR, Snyder TA, et al., 2018: Assessment of Thrombelastography and Platelet Life Span in Ovines. Artif Organs, 42 (12): 427-434.
23. Kakar N, Daniel G, Fellman C, et al., 2021: Thromboelastography in cats with cholestatic liver disease. J. Feline Med. Surg, 23 (2), 160–167.
24. Kaplan S, Altay Y, 2023: Bibliometric analysis of next-generation sequence applications in livestock. BSJ Agri, 6 (5), 485-491.
25. Kaur H, Fisher K, Othman M, 2019: Thromboelastography testing in mice following blood collection from facial vein and cardiac puncture. Blood Coagul. Fibrinolysis, 30 (7), 366–369.
26. Kol A, Nelson RW, Gosselin RC, et al., 2013: Characterization of thrombelastography over time in dogs with hyperadrenocorticism. Vet J, 197 (3), 675-81.
27. Kristensen AT, Wiinberg B, Jessen LR, et al., 2008: Evaluation of human recombinant tissue factor-activated thromboelastography in 49 dogs with neoplasia. J Vet Intern Med, 22 (1), 140–147.
28. Langhorn R, Bochsen L, Willesen JL, et al., 2019: Thromboelastography-guided transfusion in dogs with hypocoagulable disorders: a case series. Acta Vet, 61 (1), 35.
29. Lovett AL, Gilliam LL, Sykes BW, McFarlane D, 2022: Thromboelastography in obese horses with insulin dysregulation compared to healthy controls. J Vet Intern Med, 36 (3),1131-1138.
30. Majoy SB, de Laforcade AM, Barnard MR, et al., 2015: Platelet activation in a population of critically ill dogs as measured with whole blood flow cytometry and thromboelastography. Am J Vet Res, 76 (4), 328–337.
31. Mendez-Angulo JL, Mudge MC, Vilar-Saavedra P, et al., 2010: Thromboelastography in healthy horses and horses with inflammatory gastrointestinal disorders and suspected coagulopathies. J Vet Emerg Crit Care, 20 (5), 488–493.
32. Önder H, Tirink C, 2022: Bibliometric analysis for genomic selection studies in animal science. J Inst Sci Tech, 12(3), 1849-1856.
33. Otto CM, Rieser TM, Brooks MB, Russell MW, 2000: Evidence of hypercoagulability in dogs with parvoviral enteritis. J Am Vet Med Assoc, 217 (10), 1500-1504.
34. Pereira JM, Rohn K, Mischke R, 2020: Reference intervals for rotational thromboelastometry measurements using the ROTEM® delta device in dogs. Res Vet Sci, 130, 26–32.
35. Rubanick JV, Pashmakova MB, Bishop MA, et al., 2017: Correlation between thromboelastography and traditional coagulation test parameters in hospitalized dogs. Vet Med, 8 (8), 21-26.
36. Schroeder JA, Kuether EA, Fang J, et al., 2021: Thromboelastometry assessment of hemostatic properties in various murine models with coagulopathy and the effect of factor VIII therapeutics. J Thromb Haemost, 19, 2417–2427.
37. Scruggs JL, Flatland B, McCormick KA, et al., 2016: Biological variation of thromboelastrography variables in 10 clinically healthy horses. J Vet Emerg Crit Care, 26 (1), 80–84.
38. Sinnott VB, Otto CM, 2009: Use of thromboelastography in dogs with immune-mediated hemolytic anemia: 39 cases (2000-2008). J Vet Emerg Crit Care, 19 (5), 484–488.
39. Sommerey CC, Williams TL, McCrone I, et al., 2014: Thromboelastography in healthy dairy cows. J Dairy Sci, 97 (9), 5474-80.
40. Strandberg G, Lipcsey M, Eriksson M, et al., 2016: Analysis of thromboelastography, PT, APTT and fibrinogen in intraosseous and venous samples-an experimental study. Scand J Trauma Resusc, 24 (1), 131.
41. Studer KA, Hanzlicek A, Di Girolamo N, et al., 2021: Effect of rest temperature on rotational thromboelastometry in New Zealand White rabbits. J Vet Diagn Invest, 33(1), 47-51.
42. Wiinberg B, Jensen AL, Johansson PI, et al., 2008: Thromboelastographic evaluation of hemostatic function in dogs with disseminated intravascular coagulation. J Vet Intern Med, 22, 357-365.
43. Wiinberg B, Jensen AL, Rojkjaer R, Johansson P, Kjelgaard-Hansen M, Kristensen AT, 2005: Validation of human recombinant tissue factor-activated thromboelastography on citrated whole blood from clinically healthy dogs. Vet Clin Pathol, 34 (4), 389-93.
44. Wiinberg B, Kristensen AT, 2010: Thromboelastography in veterinary medicine. Semin Thromb Hemost, 36 (7), 747-56.
45. Wilkinson A, Menciotti G. Thromboelastography in cats with hypertrophic cardiomyopathy. Access via: https://research.vetmed.vt.edu/clinical-trials/current-studies/hcm-feline.html. Access date: 06.12.2023
46. Yilmaz Z, Kocatürk M, Inan OE, et al., 2017: Thromboelastographic evaluation of hemostatic functioning dogs with dilated cardiomyopathy. Turkish J Vet Anim Sci, 41 (3), 372-379.