RATLARDA FARKLI ANESTEZİ PROTOKOLLERİNİN GÖZ İÇİ BASINCI ÜZERİNE ETKİLERİNİN KARŞILAŞTIRILMASI

Abstract

Göz içi basıncı (GİB), gözün optik özelliklerinin korunmasının yanı sıra iç dokulara biyomekanik destek sağlamaktadır. Bazal değer sapmaları GİB değişiminin büyüklüğüne, yönüne ve süresine bağlı olarak görme problemlerine neden olmaktadır. Çalışmada ilk olarak sağlıklı olduğu belirlenen ratlar rastgele 4 gruba ayrıldı. Tüm gruplarda ratların 0. dakikada sağ ve sol göz içi basıncı tonometre ile ölçülerek kaydedildi. Genel anestezik ajan uygulamasından sonra 20.-30.-60.-90. ve 120. dakikalarda sağ ve sol göz içi basınçları ölçülerek kaydedildi. Grup içi karşılaştırmalarda uygulanan bütün anestezi protokollerinde zamanla GİB değerlerinin düştüğü gözlendi. Bütün grupların sağ ve sol göz GİB değerlerinin karşılaştırılmasında 0-30 dk ve 90-120 dk arası gruplar arasında anlamlı fark gözlenmemiştir (p > 0.05). 60. dakikada ise hem sağ hem de sol göz GİB değerinde gruplar arası istatistiksel olarak anlamlı fark saptandı (p < 0.05). Sonuç olarak uygulanan anestezik protokollerinin tamamında sağ ve sol gözlerin GİB değerinde düşüş gözlenmiştir. Elde edilen veriler kapsamında ratlarda ksilazin-medetomidin-propofol-ketamin kombinasyonlarının GİB üzerinde olumsuz bir etkiye sebep olmadan güvenle kullanılabileceği kanaatine varıldı.

Keywords

• Anestezi
• göz içi basıncı
• ketamin
• ksilazin
• medetomidin
• propofol

Comparison Of The Effects Of Different Anesthesia Protocols On Intraocular Pressure In Rats

Abstract

Intraocular pressure (IOP) provides biomechanical support to the internal tissues as well as protecting the optical properties of the eye. Deviations from baseline values cause vision problems depending on the magnitude, direction, and duration of IOP changes. In the study, rats determined to be healthy were first randomly divided into 4 groups. In all groups, the right and left intraocular pressures of the rats were measured and recorded with a tonometer at 0 minutes. After the administration of the general anesthetic agent, the right and left intraocular pressures were measured and recorded at 20, 30, 60, 90, and 120 minutes. In the intra-group comparisons, it was observed that IOP values decreased over time in all anesthesia protocols applied. No significant difference was observed between the groups in the comparison of right and left eye IOP values of all groups between 0-30 min and 90-120 min (p>0.05). At 60 min, statistically significant differences were found between groups in both right and left eye IOP values (p<0.05). In conclusion, a decrease in IOP values in both the right and left eyes was observed in all anesthetic protocols applied. Based on the data obtained, it was concluded that the combination of xylazine-medetomidine-propofol-ketamine anesthesia can be used safely in rats without causing an adverse effect on IOP.

Keywords

• Anesthesia
• intraocular pressure
• ketamine
• medetomidine
• propofol
• xylazine

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