Synthesis and Characterization of Sulfadiazine Derivative Schiff Base Ligand and Some Transition Metal Complexes

Abstract

Among heterocyclic compounds, thiophene and sulfadiazine ring ligands are attracting more interest in this field due to their significant biological activity. This study involves the synthesis of a thiophene-ringed Schiff base and the elucidation of the structures of first-row transition metal complexes of this ligand. The compound to be used as the ligand was synthesized from the reaction of thiophene-2,5-dicarbaldehyde and 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide. The ligand was synthesized with Cu(II), Ni(II), and Co(II) chloride salts in a 1:1 stoichiometric reaction to produce [MLCl₂(H₂O)₂]nH₂O complexes. The structures of the synthesized compounds were determined using spectroscopic and analytical techniques such as NMR (ligand), FT-IR, UV-Vis, elemental analysis (CHNS), electrolyte conductivity, and magnetic susceptibility. Magnetic susceptibility measurements for the LCu, LCo, and LNi complexes were recorded as 2.13 BM, 3.44 BM, and 2.60, respectively. The LCu, LCo, and LNi complexes have octahedral geometry. The molar conductivity values of the complexes range between 17.01-19.02 μS/cm, indicating that they do not possess conductivity properties. This study highlights the potential of Schiff base ligands containing thiophene and sulfonamide in coordination chemistry and serves as a foundation for biological activity studies of these compounds.

Keywords

• Schiff base
• thiophene
• sulfadiazine
• transition metal complexes
• coordination chemistry
• spectroscopic characterization

Supporting Institution

Gaziantep University Scientific Research Projects Department

Project Number

FEF.YLT.22.18

Thanks

Support for the completion of this project was granted by the Gaziantep University Scientific Research Projects Department (FEF.YLT.22.18).

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