Resorcinol derivatives as human acetylcholinesterase inhibitor: An In Vitro and In Silico study

Yıl 2021, Cilt: 5 Sayı: 2, 156 - 161, 31.12.2021

Uğur Güller

https://doi.org/10.32571/ijct.944620

Cited By: 2

Öz

Inhibitors of Acetylcholinesterase (Acetylcholine acetylhydrolase, AChE, E.C.3.1.1.7) are highly significant in the treatment of neurodegenerative diseases such as Alzheimer’s disease (AD) due to the deep relationship with memory and acetylcholine. So investigation of natural AChE inhibitors having minimal side effects has become important. In this paper human erythrocytes AChE enzyme (0.032 EU mg-1 protein) was partially isolated by using DE-52 anion exchange chromatography. Then, primer effects of resorcinol derivatives on the enzyme activity were studied and IC50 values were found in the range of 2.74-363.61 µM. Besides, inhibition profiles were elucidated by molecular docking and the highest inhibition potency was observed in 4-hexylresorcinol with the free binding energy of -6.16 kcal mol-1. In conclusion, by using both in vitro and in silico approaches it was found that 4-hexylresorcinol had the highest inhibitory potential on human AChE. So, this compound may be used in drug design in memory-lost diseases.

Anahtar Kelimeler

Acetylcholinesterase, resorcinol, inhibition, molecular docking

Kaynakça

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