Unveiled assets of Solanaceae family plants: Mechanistic understanding of phytochemicals with therapeutic efficacy in addressing human ailments

Madhu Kushwaha; Dr. Pankaj Tiwari

Unveiled assets of Solanaceae family plants: Mechanistic understanding of phytochemicals with therapeutic efficacy in addressing human ailments

Abstract

Plants exhibiting a wide array of bioactive compounds are pivotal for the preservation of human health and existence. The heterogeneity of bioactive compounds, each with its unique therapeutic attributes, enhances their significance within health systems, in addition to serving as a nutrient source. Investigations into the genetic structure and composition of bioactive compounds have disclosed their richness in steroidal alkaloids, saponins, terpenes, flavonoids, and phenolics. The Solanaceae family, characterized by a substantial variety of bioactive compounds exhibiting diverse pharmacological activities, presents considerable potential for the treatment of various ailments. Research focused on Solanum species has demonstrated their extensive pharmacological effects, which encompass antioxidant, hepatoprotective, cardioprotective, nephroprotective, anti-inflammatory, and anti-ulcerogenic properties. Phytochemical assessments of isolated compounds such as diosgenin, solamargine, solanine, apigenin, and lupeol have indicated their cytotoxic effects across multiple cancer cell lines, including liver cancer (HepG2, Hep3B, SMMC-772), lung cancer (A549, H441, H520), human breast cancer (HBL-100), and prostate cancer (PC3). Given that analyses of their phytochemical constituents have demonstrated a significant impact on numerous signaling pathways, considerable scholarly attention has been directed towards elucidating the biological targets and cellular mechanisms implicated therein. In light of the promising attributes of bioactive constituents from various Solanum species, the primary focus has been on identifying and documenting significant cultivars, their phytochemical profiles, and their pharmacological characteristics. This review provides mechanistic insights into the bioactive components aimed at addressing various health conditions with minimal adverse effects, thereby contributing to advancements in medical research.

Keywords

References

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Details

Primary Language

English

Subjects

Ecotoxicology

Journal Section

Review Article

Authors

Madhu Kushwaha ^*
0009-0006-1927-9920
India

Dr. Pankaj Tiwari
0000-0003-2548-0111
India

Publication Date

December 25, 2025

Submission Date

January 8, 2025

Acceptance Date

June 27, 2025

Published in Issue

Year 1970 Volume: 8 Number: 2

IZ

https://izlik.org/JA88RA33CK

Cite

RIS / Bibtex

APA

Kushwaha, M., & Tiwari, D. P. (2025). Unveiled assets of Solanaceae family plants: Mechanistic understanding of phytochemicals with therapeutic efficacy in addressing human ailments. International Journal of Environmental Pollution and Environmental Modelling, 8(2), 99-112. https://izlik.org/JA88RA33CK

AMA

1.Kushwaha M, Tiwari DP. Unveiled assets of Solanaceae family plants: Mechanistic understanding of phytochemicals with therapeutic efficacy in addressing human ailments. Int. j. environ. pollut. environ. model. 2025;8(2):99-112. https://izlik.org/JA88RA33CK

Chicago

Kushwaha, Madhu, and Dr. Pankaj Tiwari. 2025. “Unveiled Assets of Solanaceae Family Plants: Mechanistic Understanding of Phytochemicals With Therapeutic Efficacy in Addressing Human Ailments”. International Journal of Environmental Pollution and Environmental Modelling 8 (2): 99-112. https://izlik.org/JA88RA33CK.

EndNote

Kushwaha M, Tiwari DP (December 1, 2025) Unveiled assets of Solanaceae family plants: Mechanistic understanding of phytochemicals with therapeutic efficacy in addressing human ailments. International Journal of Environmental Pollution and Environmental Modelling 8 2 99–112.

IEEE

[1]M. Kushwaha and D. P. Tiwari, “Unveiled assets of Solanaceae family plants: Mechanistic understanding of phytochemicals with therapeutic efficacy in addressing human ailments”, Int. j. environ. pollut. environ. model., vol. 8, no. 2, pp. 99–112, Dec. 2025, [Online]. Available: https://izlik.org/JA88RA33CK

ISNAD

Kushwaha, Madhu - Tiwari, Dr. Pankaj. “Unveiled Assets of Solanaceae Family Plants: Mechanistic Understanding of Phytochemicals With Therapeutic Efficacy in Addressing Human Ailments”. International Journal of Environmental Pollution and Environmental Modelling 8/2 (December 1, 2025): 99-112. https://izlik.org/JA88RA33CK.

JAMA

1.Kushwaha M, Tiwari DP. Unveiled assets of Solanaceae family plants: Mechanistic understanding of phytochemicals with therapeutic efficacy in addressing human ailments. Int. j. environ. pollut. environ. model. 2025;8:99–112.

MLA

Kushwaha, Madhu, and Dr. Pankaj Tiwari. “Unveiled Assets of Solanaceae Family Plants: Mechanistic Understanding of Phytochemicals With Therapeutic Efficacy in Addressing Human Ailments”. International Journal of Environmental Pollution and Environmental Modelling, vol. 8, no. 2, Dec. 2025, pp. 99-112, https://izlik.org/JA88RA33CK.

Vancouver

1.Madhu Kushwaha, Dr. Pankaj Tiwari. Unveiled assets of Solanaceae family plants: Mechanistic understanding of phytochemicals with therapeutic efficacy in addressing human ailments. Int. j. environ. pollut. environ. model. [Internet]. 2025 Dec. 1;8(2):99-112. Available from: https://izlik.org/JA88RA33CK