Green Synthesis and Characterization of Anticancer Effected Silver Nanoparticles with Silverberry (Elaeagnus angustifolia) Fruit Aqueous Extract

Yıl 2021, Cilt: 7 Sayı: 3, 391 - 400, 31.12.2021

Ömer Erdoğan Salih Paşa Ozge Cevik

https://doi.org/10.29132/ijpas.915005

Cited By: 2

Öz

Cancer is the deadliest health problem after cardiovascular system diseases. New strategies have been developed over the years in the fight against cancer. Silver nanoparticles are one of these approaches. In this study, it was aimed to synthesize silver nanoparticles with the green approach using Elaeagnus angostifolia aqueous extract and to investigate the cytotoxic effects of these nanoparticles. Silver nanoparticles have been characterized by analytical methods such as UV-Vis, FTIR, SEM, EDX. The peak around 3 keV in the EDX spectrum confirms the synthesis of silver nanoparticles. In vitro cytotoxic activity of silver nanoparticles was tested on human prostate cancer cell line PC3, human cervical cancer cell line HELA and normal mouse fibroblast cell line L929. It has been found that silver nanoparticles synthesized with the aqueous extract of Elaeagnus angustifolia showed a dose-dependent cytotoxic effect on HELA and PC3 cells.

Anahtar Kelimeler

Anti-cancer, Elaeagnus angustifolia, green synthesis, silverberry, silver nanoparticles

Destekleyen Kurum

This work was partly supported by Adnan Menderes University Research Grant .

Proje Numarası

ADU-MARL-18001 and ADU-TPF19037

Teşekkür

The analysis was conducted by the Adnan Menderes University Science and Technology Research Center (ADU-BILTEM), of which is gratefully acknowledged.

Antikanser Etkili Gümüş Nanopartiküllerinin İğde (Elaeagnus angustifolia) Meyvesi Sulu Ekstraktı ile Yeşil Sentezi ve Karaktarizasyonu

Öz

Kanser kardiyovasküler sistem hastalıklarından sonra gelen en ölümcül sağlık problemidir. Kanserle mücadelede yıllar içerisinde yeni stratejiler geliştirilmiştir. Gümüş nanopartikülleri bu yaklaşımlardan bir tanesidir. Bu çalışmada Elaeagnus angostifolia sulu ekstraktı kullanılarak gümüş nanopartiküllerinin yeşil sentezi ve bu nanopartiküllerin sitotoksik etkilerinin belirlenmesi amaçlanmıştır. Gümüş nanopartikülleri UV-Vis, FTIR, SEM, EDX gibi analitik metotlar ile karakterize edilmiştir. EDX spektrumunda 3 keV civarındaki pik gümüş nanopartiküllerinin sentezini doğrulamaktadır. Gümüş nanopartiküllerinin in vitro sitotoksik aktivitesi insan prostat kanser hücre hattı PC3, insan serviks kanseri hücre hattı HELA ve normal mouse fibroblast hücre hattı L929 üzerinde test edilmiştir. Elaeagnus angustifolia sulu ekstraktı ile sentezlenen gümüş nanopartiküllerinin HELA ve PC3 hücreleri üzerinde doza bağımlı sitotoksik etki gösterdiği bulunmuştur.

Anahtar Kelimeler

Anti-kanser, Elaeagnus angustifolia, yeşil sentez, iğde, gümüş nanopartikülleri

Proje Numarası

ADU-MARL-18001 and ADU-TPF19037

Kaynakça

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