Salvia cadmica as a potential agent in biofilm-related infection prevention

Nilay İşitez; Sevim Feyza Erdoğmuş; Cengiz Sarıkürkcü

doi:10.21448/ijsm.1656804

Salvia cadmica as a potential agent in biofilm-related infection prevention

Abstract

This study investigates the antibiofilm activity of Salvia cadmica (S. cadmica) aqueous-ethanol extract against Staphylococcus aureus (S. aureus) ATCC 25923, a well-known biofilm-forming bacterium. The antibiofilm efficacy of the extract on both planktonic and biofilm forms of S. aureus ATCC 25923 was assessed using the MTT reduction assay, while morphological alterations were examined by scanning electron microscopy. A dose-dependent increase in biofilm inhibition was observed, with biofilm inhibition and eradication rates reaching 34.07±0.44% and 35.71±0.4%, respectively, at 2× MIC concentration of plant extract. Microbiological analyses confirmed the antibiofilm potential of S. cadmica extract against S. aureus ATCC 25923. These findings highlight the promising antibiofilm properties of Salvia cadmica extract, suggesting its potential application in the treatment of infections associated with biofilm-forming S. aureus ATCC 25923. Future research should aim to isolate and characterize individual bioactive compounds from S. cadmica to better understand their mechanisms of action and potential synergistic effects.

Keywords

Supporting Institution

Afyonkarahisar Health Sciences University

Project Number

24.GENEL.003

Ethical Statement

No ethical objection to conducting the research (19/04/2024 - 2024/2 Afyonkarahisar Health Sciences University Non-Intervention Scientific Research Ethics Committee).

Thanks

This study was supported by Afyonkarahisar Health Sciences University Scientific Research Projects Coordination, Project number 24. GENEL. 003.

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Details

Primary Language

English

Subjects

Pharmaceutical Microbiology

Journal Section

Research Article

Authors

Nilay İşitez ^*
0000-0002-1928-7158
Türkiye

Sevim Feyza Erdoğmuş
0000-0002-4319-7558
Türkiye

Cengiz Sarıkürkcü
0000-0001-5094-2520
Türkiye

Early Pub Date

September 1, 2025

Publication Date

December 5, 2025

Submission Date

March 13, 2025

Acceptance Date

July 17, 2025

Published in Issue

Year 2025 Volume: 12 Number: 4

DOI

https://doi.org/10.21448/ijsm.1656804

IZ

https://izlik.org/JA32SP53WM

Cite

RIS / Bibtex

APA

İşitez, N., Erdoğmuş, S. F., & Sarıkürkcü, C. (2025). Salvia cadmica as a potential agent in biofilm-related infection prevention. International Journal of Secondary Metabolite, 12(4), 743-754. https://doi.org/10.21448/ijsm.1656804

AMA

1.İşitez N, Erdoğmuş SF, Sarıkürkcü C. Salvia cadmica as a potential agent in biofilm-related infection prevention. Int. J. Sec. Metabolite. 2025;12(4):743-754. doi:10.21448/ijsm.1656804

Chicago

İşitez, Nilay, Sevim Feyza Erdoğmuş, and Cengiz Sarıkürkcü. 2025. “Salvia Cadmica As a Potential Agent in Biofilm-Related Infection Prevention”. International Journal of Secondary Metabolite 12 (4): 743-54. https://doi.org/10.21448/ijsm.1656804.

EndNote

İşitez N, Erdoğmuş SF, Sarıkürkcü C (December 1, 2025) Salvia cadmica as a potential agent in biofilm-related infection prevention. International Journal of Secondary Metabolite 12 4 743–754.

IEEE

[1]N. İşitez, S. F. Erdoğmuş, and C. Sarıkürkcü, “Salvia cadmica as a potential agent in biofilm-related infection prevention”, Int. J. Sec. Metabolite, vol. 12, no. 4, pp. 743–754, Dec. 2025, doi: 10.21448/ijsm.1656804.

ISNAD

İşitez, Nilay - Erdoğmuş, Sevim Feyza - Sarıkürkcü, Cengiz. “Salvia Cadmica As a Potential Agent in Biofilm-Related Infection Prevention”. International Journal of Secondary Metabolite 12/4 (December 1, 2025): 743-754. https://doi.org/10.21448/ijsm.1656804.

JAMA

1.İşitez N, Erdoğmuş SF, Sarıkürkcü C. Salvia cadmica as a potential agent in biofilm-related infection prevention. Int. J. Sec. Metabolite. 2025;12:743–754.

MLA

İşitez, Nilay, et al. “Salvia Cadmica As a Potential Agent in Biofilm-Related Infection Prevention”. International Journal of Secondary Metabolite, vol. 12, no. 4, Dec. 2025, pp. 743-54, doi:10.21448/ijsm.1656804.

Vancouver

1.Nilay İşitez, Sevim Feyza Erdoğmuş, Cengiz Sarıkürkcü. Salvia cadmica as a potential agent in biofilm-related infection prevention. Int. J. Sec. Metabolite. 2025 Dec. 1;12(4):743-54. doi:10.21448/ijsm.1656804