Poly(amidoamine) dendrimers (PAMAM) are polymeric macromolecules that can find their use as carriers of small ligand molecules such as cosmetics and drugs. 5- Fluorouracil is a potent oncological drug, whose usage is limited because of its relatively high toxicity.The surface and internal layer groups in PAMAM dendrimer belonging to the third (G3) generation create an open-type structure, which facilitate small ligand molecules to bind with them.The formation equilibrium of PAMAM G3 dendrimer complex with an oncologic drug such as 5 fluorouracil (FU) in water at room temperature was examined. Using the results of the drug solubility in dendrimer solutions, the maximal number of drug molecules in the dendrimer-drug complex was evaluated. Solubility results show that PAMAM G3 dendrimer can transfer tens 5 fluorouracil molecules in aqueous solution.This research work was funded from the Polish budget appropriations for science in the years 2013-2015, project number IP2012 022372.
Birincil Dil | İngilizce |
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Konular | Yapısal Biyoloji |
Diğer ID | JA37RP73KM |
Bölüm | Makaleler |
Yazarlar | |
Yayımlanma Tarihi | 14 Temmuz 2014 |
Gönderilme Tarihi | 14 Temmuz 2016 |
Yayımlandığı Sayı | Yıl 2014 Cilt: 1 Sayı: 1 |