Association between hepatosteatosis and severity of COVID-19 pneumonia: a CT-based study

Esra Soyer Güldoğan; Serra Özbal; Yeliz Aktürk; İrfan Şencan; Baki Hekimoğlu

doi:10.17944/interdiscip.1698641

Association between hepatosteatosis and severity of COVID-19 pneumonia: a CT-based study

Abstract

Objective: Recent studies show that comorbidities are a risk factor for coronavirus disease 2019 (COVID-19) pneumonia. We aimed to evaluate whether hepatosteatosis (HS) plays a role in predicting the severity of the disease. Method: We included 505 patients whose real-time polymerase chain reaction tests were positive and who had a thoracic computed tomography (CT) scan. Age, gender, height-weight, and comorbidities of the patients were noted. Three radiologists re-evaluated thoracic CTs, and the severity score (between 20-40 was considered a severe disease) was determined. Liver and spleen densities were measured by standardizing, the liver-spleen density ratio was selected, and steatosis was defined as ≤0.8. We used X2 and student t-test, logistic regression, and odds ratio with a 95% confidence interval. Results: In 149 (29.5%) patients, liver/spleen density ratios favored adiposity. The mean tomography severity score of the patients was 16 (±10.5). When we look at the distribution of 192 (38%) patients with a CT severity score of ≥20; the number of patients over 65 years of age and the male gender were higher. We also found a higher rate of HS in this group compared to the group with a lower CT severity score. When the correlation between the patients’ liver/spleen density ratios and the severity of pneumonia was examined, we observed that the severity of the disease increased significantly as the liver/spleen density ratio decreased (p<0.001). Conclusion: HS and age were independently related with severe COVID-19 pneumonia. For patients who have viral pneumonia, the liver-spleen density ratio might be measured.

Keywords

References

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Details

Primary Language

English

Subjects

Clinical Sciences (Other)

Journal Section

Research Article

Authors

Esra Soyer Güldoğan ^*
Türkiye

Serra Özbal
Türkiye

Yeliz Aktürk
Türkiye

İrfan Şencan
Türkiye

Baki Hekimoğlu
Türkiye

Publication Date

December 16, 2025

Submission Date

May 13, 2025

Acceptance Date

September 2, 2025

Published in Issue

Year 2025 Volume: 16 Number: 56

DOI

https://doi.org/10.17944/interdiscip.1698641

IZ

https://izlik.org/JA24PL67HJ

Cite

RIS / Bibtex

APA

Soyer Güldoğan, E., Özbal, S., Aktürk, Y., Şencan, İ., & Hekimoğlu, B. (2025). Association between hepatosteatosis and severity of COVID-19 pneumonia: a CT-based study. Interdisciplinary Medical Journal, 16(56), 148-154. https://doi.org/10.17944/interdiscip.1698641

AMA

1.Soyer Güldoğan E, Özbal S, Aktürk Y, Şencan İ, Hekimoğlu B. Association between hepatosteatosis and severity of COVID-19 pneumonia: a CT-based study. Interdiscip Med J. 2025;16(56):148-154. doi:10.17944/interdiscip.1698641

Chicago

Soyer Güldoğan, Esra, Serra Özbal, Yeliz Aktürk, İrfan Şencan, and Baki Hekimoğlu. 2025. “Association Between Hepatosteatosis and Severity of COVID-19 Pneumonia: A CT-Based Study”. Interdisciplinary Medical Journal 16 (56): 148-54. https://doi.org/10.17944/interdiscip.1698641.

EndNote

Soyer Güldoğan E, Özbal S, Aktürk Y, Şencan İ, Hekimoğlu B (December 1, 2025) Association between hepatosteatosis and severity of COVID-19 pneumonia: a CT-based study. Interdisciplinary Medical Journal 16 56 148–154.

IEEE

[1]E. Soyer Güldoğan, S. Özbal, Y. Aktürk, İ. Şencan, and B. Hekimoğlu, “Association between hepatosteatosis and severity of COVID-19 pneumonia: a CT-based study”, Interdiscip Med J, vol. 16, no. 56, pp. 148–154, Dec. 2025, doi: 10.17944/interdiscip.1698641.

ISNAD

Soyer Güldoğan, Esra - Özbal, Serra - Aktürk, Yeliz - Şencan, İrfan - Hekimoğlu, Baki. “Association Between Hepatosteatosis and Severity of COVID-19 Pneumonia: A CT-Based Study”. Interdisciplinary Medical Journal 16/56 (December 1, 2025): 148-154. https://doi.org/10.17944/interdiscip.1698641.

JAMA

1.Soyer Güldoğan E, Özbal S, Aktürk Y, Şencan İ, Hekimoğlu B. Association between hepatosteatosis and severity of COVID-19 pneumonia: a CT-based study. Interdiscip Med J. 2025;16:148–154.

MLA

Soyer Güldoğan, Esra, et al. “Association Between Hepatosteatosis and Severity of COVID-19 Pneumonia: A CT-Based Study”. Interdisciplinary Medical Journal, vol. 16, no. 56, Dec. 2025, pp. 148-54, doi:10.17944/interdiscip.1698641.

Vancouver

1.Esra Soyer Güldoğan, Serra Özbal, Yeliz Aktürk, İrfan Şencan, Baki Hekimoğlu. Association between hepatosteatosis and severity of COVID-19 pneumonia: a CT-based study. Interdiscip Med J. 2025 Dec. 1;16(56):148-54. doi:10.17944/interdiscip.1698641