Electrospinning method to produce drug-loaded nanofibers for topical/ transdermal drug delivery applications

Year 2016, Volume: 46 Issue: 1, 49 - 69, 24.08.2016

İmren Esentürk , M. Sedef Erdal , Sevgi Güngör

Abstract

Electrospinning is the method for preparing drug-loaded nanofibers with ultrafine structure, a large surface area to volume ratio, and a high porosity with a small pore size. Among the other nanofiber production methods, electrospinning is the most cost effective one with simple tooling and, it is applicable to produce ultrafine fibers with a simple step-up production for drug delivery applications.The selection of the polymer as carrier for electrospinning and the production procedure design is crucial due to drug-polymer-solvent interactions and the other process parameters which would influence the physicochemical biocompatibilityand characteristics.This technique can be applied to produce nanofibers of a wide array of polymer types: natural, synthetic polymers, or their blends.This review focuses on various electrospinning methods to produce drug loaded nanofibers, polymers used, electrospinning process parameters, their advantages and limitations for topical/transdermal drug delivery applications.

Keywords

Nanofiber, electrospinning, topical drug delivery, transdermal drug delivery

References

• Abrigo M, McArthur SL, Kingshott P (2014) Electrospun Nanofibers as Dressings for Chronic Wound Care: Advances, Challenges, and Future Prospects, Macromol. Biosci., 14: 772-792.
• Ajalloueian F, Tavanai H, Hilborn J, Donzel-Gargand O, Leifer K, Wickham A, Arpanaei A (2014) Emulsion Electrospinning as an Approach to Fabricate PLGA/Chitosan Nanofibers for Biomedical Applications, Biomed. Res. Int., doi: 10.1155/2014/475280.
• Araújo ES, Nascimento MLF, Oliveira HP (2013) Influence of Triton X-100 on PVA Fibres Production by the Electrospinning Technique, Fibres & Textiles, 21, 4(100): 39-43.
• Arthanari S, Mani G, Jang JH, Choi JO, Cho YH, Lee JH, Cha SE, Oh HS, Kwon DH, Jang HT (2014) Preparation and characterization of gatifloxacin-loaded alginate/poly (vinyl alcohol) electrospun nanofibers, Artif. Cells Nanomed. Biotechnol., doi: 10.3109/21691401.2014.986676.
• Azarbayjani AF, Venugopal JR, Ramakrishna S, Lim PFC, Chan YW, Chan SY (2010) SmartPolymeric Nanofibers for Topical Delivery of Levothyroxine, Pharm. Pharmaceut. Sci., 13(3): 400-410.
• Bhardwaj N, Kundu SC (2010) Electrospinning: A fascinating fiber fabrication technique, Biotechnol. Adv., 28: 325-347.
• Boguń M, Krucińska I, Kommisarczyk A, Mikołajczyk T, Błażewicz M, Stodolak-Zych E, Menaszek E, Ścisłowska-Czarnecka A (2013) Fibrous Polymeric Composites Based on Alginate Fibres and Fibres Made of Poly-ε-caprolactone and Dibutyryl Chitin for Use in Regenerative Medicine, Molecules,18: 3118-3136.
• Brenner EK, Schiffman JD, Thompson EA, Toth LJ, Schauer CL (2012) Electrospinning of hyaluronic acid nanofibers from aqueous ammonium solutions, Carbohydr. Polym.,87: 926-929.
• Chen M, Li YF, Besenbacher F (2014) Electrospun Nanofibers-Mediated On-Demand Drug Release, Adv. Healthcare Mater., 3: 1721-1732.
• Choi JS, Kim HS, Yoo HS (2015) Electrospinning strategies of drug-incorporated nanofibrous mats for wound recovery, Drug Deliv. and Transl. Res., 5:137-145.
• Cramariuc B, Cramariuc R, Scarlet R, Manea LR, Lupu IG, Cramariuc O (2013) Fiber diameter in electrospinning process, J. Electrostat., 71: 189-198.
• De Vrieze S, Van Camp T, Nelvig A, Hagstrom B, Westbroek P, De Clerck K (2009) The effect of temperature and humidity on electrospinning, J. Mater. Sci., 44: 1357-1362.
• Esenturk I, Balkan T, Gungor S, Sarac AS, Erdal MS (2016) Voriconazole-loaded electrospun nanofibers as topical drug carriers, 7th European Dermatology Congress, June 13-14, 2016 Alicante, Spain (accepted as poster presentation).
• Fischer RL, McCoy MG, Grant SA (2012) Electrospinning collagen and hyaluronic acid nanofiber meshes, J. Mater. Sci.: Mater. Med.,23:1645-1654.
• Gencturk A, Kahraman E, Gungor S, Ozhan G, Ozsoy Y, Sarac AS (2016) Polyurethane/hydroxypropyl cellulose electrospun nanofiber mats as potential transdermal drug delivery system: characterization studies and in vitro assays, Artif. Cell Blood Sub., DOI: 10.3109/21691401.2016.1173047.
• Goh YF, Shakir I, Hussain R (2013) Electrospun fibers for tissue engineering, drug delivery, and wound dressing, J. Mater. Sci., 48: 3027-3054.
• Gomes SR, Rodrigues G, Martins GG, Roberto MA, Mafra M, Henriques CMR, Silva JC (2015) In vitro and in vivo evaluation of electrospun nanofibers of PCL, chitosan and gelatin: A comparative study, Mater. Sci. Eng. C, 46: 348-358.
• Gupta P, Elkins C, Long TE, Wilkes GL (2005) Electrospinning of linear homopolymers of poly(methyl methacrylate): exploring relationships between fiber formation, viscosity, molecular weight and concentration in a good solvent, Polymer,46: 4799-4810.
• Haghi AK, Akbari M (2007) Trends in electrospinning of natural nanofibers, Phys. Stat. Sol., 204(6): 1830-1834.
• Heunis TDJ and Dicks LMT (2010) Nanofibers Offer Alternative Ways to the Treatment of Skin Infections, J. Biomed. Biotechnol., doi: 10.1155/2010/510682.
• Holan V, Chudickova M, Trosan P, Svobodova E, Krulova M, Kubinova S, Sykova E, Sirc J, Michalek J, Juklickova M, Munzarova M, Zajicova A (2011) Cyclosporine A-loaded and stem cell-seeded electrospun nanofibers for cell-based therapy and local immunosuppression, J. Control. Release, 156: 406-412.
• Hu X, Liu S, Zhou G, Huang Y, Xie Z, Jing X (2014) Electrospinning of polymeric nanofibers for drug delivery applications, J. Control. Release, 185: 12-21.
• Jang SI, Mok JY, Jeon IH, Park KH, Nguyen TTT, Park JS, Hwang HM, Song MS, Lee D, Chai KY (2012) Effect of Electrospun Non-Woven Mats of Dibutyryl Chitin/ Poly(Lactic Acid) Blends on Wound Healing in Hairless Mice, Molecules,17: 2992-3007.
• Jiang H, Fang D, Hsiao B, Chu B, Chen W (2004) Preparation and characterization of ibuprofen loaded poly(lactide-co-glycolide)/poly(ethylene glycol)-g-chitosan electrospun membranes, J. Biomater. Sci. Polymer Edn., 15(3): 279-296.
• Jin G, Prabhakaran MP, Kai D, Ramakrishna S (2013) Controlled release of multiple epidermal induction factors through core–shell nanofibers for skin regeneration, Eur. J. Pharm. Biopharm., 85: 689-698.
• Kai D, Liowa SS, Loh XJ (2014) Biodegradable polymers for electrospinning: Towards biomedical applications, Mater. Sci. Eng. C, 45: 659-670.
• Kataria K, Gupta A, Rath G, Mathur RB, Dhakate SR (2014) In vivo wound healing performance of drug loaded electrospun composite nanofibers transdermal patch, Int. J. Pharm., 469: 102-110.
• Lakshminarayanan R, Sridhar R, Loh XJ, Nandhakumar M, Barathi VA, Kalaipriya M, Kwan JL, Liu SP, Beuerman RW, Ramakrishna S (2014) Interaction of gelatin with polyenes modulatesantifungal activity and biocompatibility of electrospun fiber mats, Int. J. Nanomedicine, 9: 2439-2458.
• Lim YM, Gwon HJ, Jeun JP, Nho YC (2010) Preparation of Cellulose based Nanofibers Using Electrospinning, In: Kumar A (ed.), Nanofibers, InTech, Croatia, pp. 179-188.
• Madhaiyan K, Sridhar R, Sundarrajan S, Venugopal JR, Ramakrishna S (2013) Vitamin B12 loaded polycaprolactone nanofibers: A novel transdermal route for the water soluble energy supplement delivery, Pharm. Nanotechnol., 444: 70-76.
• Maleki M, Latifi M, Amani-Tehran M, Mathur S (2013) Electrospun Core–Shell Nanofibers for Drug Encapsulation and Sustained Release, Polym. Eng. Sci., doi: 10.1002/pen.23426.
• Medeiros ES, Mattoso LHC, Ito EN, Gregorski KS, Robertson GH, Offeman RD, Wood DF, Orts WJ, Imam SH (2008) Electrospun Nanofibers of Poly(vinyl alcohol) Reinforcedwith Cellulose Nanofibrils, J. Biobased. Mater. Bio., 2: 1-12.
• Opanasopit P, Sila-on W, Rojanarata T, Ngawhirunpat T (2013) Fabrication and properties of capsicum extract-loaded PVA and CA nanofiber patches, Pharm. Dev. Technol., 18(5): 1140-1147.
• Paaver U, Tamm I, Laidmäe I, Lust A, Kirsimäe K, Veski P, Kogermann K, Heinämäki J (2014) Soluplus Graft Copolymer: Potential Novel Carrier Polymer in Electrospinning of Nanofibrous Drug Delivery Systems for Wound Therapy, Biomed. Res. Int., doi: 10.1155/2014/789765.
• Pawar MD, Rathna GVN, Agrawal S, Kuchekar BS (2015) Bioactive thermoresponsive polyblend nanofiber formulations for wound healing, Mater. Sci. Eng. C, 48: 126-137.
• Pelipenko J, Kocbek P, Kristl J (2015) Critical attributes of nanofibers: Preparation, drug loading, and tissue regeneration, Int. J. Pharm., 484: 57-74.
• Pelipenko J, Kristl J, Jankovic B, Baumgartner S, Kocbek P (2013) The impact of relative humidity during electrospinning on the morphology and mechanical properties of nanofibers, Int. J. Pharm., 456: 125-134.
• Pelipenko J, Kristl J, Rošic R, Baumgartner S, Kocbek P (2012) Interfacial rheology: An overview of measuring techniques and its role in dispersions and electrospinning, Acta Pharm., 62: 123-140.
• Pillay V, Dott C, Choonara YE, Tyagi C, Tomar L, Kumar P, du Toit LC, Ndesendo VMK (2013) A Review of the Effect of Processing Variables on the Fabrication of Electrospun Nanofibers for Drug Delivery Applications, J Nanomater, doi: 10.1155/2013/789289.
• Qi H, Hu P, Xu J, Wang A (2006) Encapsulation of Drug Reservoirs in Fibers by Emulsion Electrospinning: Morphology Characterization and Preliminary Release Assessment, Biomacromolecules, 7: 2327-2330.
• Quirós J, Borges JP, Boltes K, Rodea-Palomares I, Rosal R (2015) Antimicrobial electrospun silver-, copper- and zinc-doped polyvinylpyrrolidone nanofibers, J. Hazard. Mater., 299: 298-305.
• Rajangam T, An SSA (2013) Fibrinogen and fibrin based micro and nano scaffolds incorporated with drugs, proteins, cells and genes for therapeutic biomedical applications, Int. J. Nanomedicine, 8: 3641-3662.
• Rim NG, Shin CS, Shin H (2013) Current approaches to electrospun nanofibers for tissue engineering, Biomed. Mater., doi:10.1088/1748-6041/8/1/014102.
• Rošic R, Pelipenko J, Kocbek P , Baumgartner S, Bešter-Rogac M, Kristl J (2012) The role of rheology of polymer solutions in predicting nanofiber formation by electrospinning, Eur. Polym. J., 48: 1374-1384.
• Sebe I, Szabó P, Kállai-Szabóc B, Zelkóa R (2015) Incorporating small molecules or biologics into nanofibers for optimized drug release: A review, Int. J. Pharm., 494: 516-530.
• Shalumona KT, Anulekhaa KH, Chennazhia KP, Tamurab H, Naira SV, Jayakumara R (2011) Fabrication of chitosan/poly(caprolactone) nanofibrous scaffold for bone and skin tissue engineering, Int. J. Biol. Macromol.,48: 571-576.
• Shan X, Li F, Liu C, Gao Q (2014) Electrospinning of Chitosan/Poly(lactic acid) Nanofibers: The Favorable Effect of Nonionic Surfactant, J. Appl. Polym. Sci., doi: 10.1002/app.41098.
• Shen X, Xu Q, Xu S, Li J, Zhang N, Zhang L (2014) Preparation and Transdermal Diffusion Evaluation of the Prazosin Hydrochloride-Loaded Electrospun Poly(vinyl alcohol) Fiber Mats, J. Nanosci. Nanotechnol., 14: 5258-5265.
• Son WK, Youk JH, Lee TS, Park WH (2004) The effects of solution properties and polyelectrolyte on electrospinning of ultrafine poly(ethylene oxide) fibers, Polymer,45: 2959-2966.
• Son YJ, Kim WJ, Yoo HS (2014) Therapeutic applications of electrospun nanofibers for drug delivery systems, Arch. Pharm. Res.,37:69–78.
• Swindle-Reilly KE, Paranjape CS, Miller CA (2014) Electrospun poly(caprolactone)-elastin scaffolds for peripheral nerve regeneration, Prog. Biomater., doi: 10.1007/s40204-014-0020-0.
• Taepaiboon P, Rungsardthong U, Supaphol P (2007) Vitamin-loaded electrospun cellulose acetate nanofiber mats as transdermal and dermal therapeutic agents of vitamin A acid and vitamin E, Eur. J. Pharm. Biopharm., 67: 387-397.
• Ulubayram K, Calamak S, Shahbazi R, Eroglu I (2015) Nanofibers Based Antibacterial Drug Design, Delivery and Applications, Curr. Pharm. Des., 21: 1930-1943.
• Unnithan AR, Gnanasekaran G, Sathishkumar Y, Lee YS, Kim CS (2014) Electrospun antibacterial polyurethane–cellulose acetate–zeincomposite mats for wound dressing, Carbohydr. Polym.,102: 884-892.
• Vatankhah E, Prabhakaran MP, Jin G, Mobarakeh LG, Ramakrishn S (2014) Development of nanofibrous cellulose acetate/gelatin skin substitutes for variety wound treatment applications, J. Biomater. Appl., 28(6): 909-921.
• Xu F, Wenga B, Gilkerson R, Materon LA, Lozano K (2015) Development of tannic acid/chitosan/pullulan composite nanofibersfrom aqueous solution for potential applications as wound dressing, Carbohydr. Polym.,115: 16-24.
• Zheng JY, Zhuang MF, Yu ZJ, Zheng GF, Zhao Y, Wang H, Sun DH (2014) The Effect of Surfactants on the Diameter and Morphology of Electrospun Ultrafine Nanofiber, J. Nanomater., doi: 10.1155/2014/689298.
• Ziani K, Henrist C, Jérôme C, Aqil A, Maté JI, Cloots R (2011) Effect of nonionic surfactant and acidity on chitosan nanofibers with different molecular weights, Carbohydr. Polym.,83: 470-476.
• Zulkifli FH, Hussain FSJ, Rasad MSBA, Yusoff MM (2014) Nanostructured materials from hydroxyethyl cellulose for skintissue engineering, Carbohydr. Polym.,114: 238-245.
• Zulkifli FH, Hussain FSJ, Rasad MSBA, Yusoff MM (2015) Improved cellular response of chemically crosslinked collagen in] corporated hydroxyethyl cellulose/poly(vinyl) alcohol nanofibers scaffold, J. Biomater. Appl., 29(7): 1014-1027.