Arnitriptyline, a tricyclic antidepressant which is mainly used for major
depression treatment, was investigated about its antimuscarinic effects and as a
result it was found generally non-selective and 100 fold less active than atropine
(1,2,3,4). There are no satisfactory information about opipramole's antirnuscarinic
activity and selectivity.
Experiments were based on measuring agonist and antagonist responses in
isolated tissues in physiological conditions.
Key words: Antimuscarinic activity, Tricyclic antidepressants, Arnitriptyline,
Opipramole.
Arnitriptyline, a tricyclic antidepressant which is mainly used for major
depression treatment, was investigated about its antimuscarinic effects and as a
result it was found generally non-selective and 100 fold less active than atropine (1,2,3,4). There are no satisfactory information about opipramole's antirnuscarinic activity and selectivity.
Experiments were based on measuring agonist and antagonist responses in
isolated tissues in physiological conditions.
Antimuscarinic activity Tricyclic antidepressant Arnitriptyline Opipramole
Birincil Dil | İngilizce |
---|---|
Konular | Eczacılık ve İlaç Bilimleri |
Bölüm | Makaleler |
Yazarlar | |
Yayımlanma Tarihi | 9 Eylül 2015 |
Yayımlandığı Sayı | Yıl 1998 Cilt: 32 |