Double-Layer Nanofibrous Mats Loaded with Lidocaine Hydrochloride and Silver Sulfadiazine: Physicochemical Characterization and in vitro Release Studies

Sewar Talal Ali Abuassi; Emine Kahraman

doi:10.26650/IstanbulJPharm.2025.1691720

Double-Layer Nanofibrous Mats Loaded with Lidocaine Hydrochloride and Silver Sulfadiazine: Physicochemical Characterization and in vitro Release Studies

Abstract

Background and Aims: Electrospun nanofibrous systems are promising platforms for wound healing due to their high surface area, porosity, and tunable drug release. This study aimed to develop a doublelayered electrospun nanofibrous mat incorporating lidocaine hydrochloride and silver sulfadiazine for potential burn and wound treatment, focusing on the physicochemical characteristics and in vitro drug release. Methods: Polyvinyl alcohol and polyurethane served as polymer matrices for loading lidocaine hydrochloride and silver sulfadiazine, respectively. The electrospinning conditions were optimised varying polymer concentrations (5 – 16% w/v), voltage, flow rate, and tip-to-collector distance. The resulting mats were characterised for drug–polymer compatibility, morphology, fibre diameter, porosity, tensile strength, drug content uniformity, and in vitro drug release. The drug release data were fitted to zero-order, first-order, Higuchi, and Korsmeyer–Peppas models. Results: Smooth, bead-free nanofibers forming the double-layer mat were successfully fabricated using optimised electrospinning solutions and process parameters. FT-IR and DSC analysis confirmed no significant drug–polymer interactions. SEM images and porosity analysis demonstrated that the doublelayer structure possessed high surface area and porosity, which are favourable for wound treatment. Furthermore, the mat exhibited adequate tensile strength and uniform drug distribution. in vitro drug release results indicated that PVA layer provided rapid release (100% within 90 min), supporting the desired anaesthetic effect. In contrast, PU layer ensured the sustained release of the antimicrobial drug, following the Korsmeyer–Peppas kinetics indicative of the diffusion-controlled mechanism. Conclusion: These findings highlight the potential of double-layer nanofibrous mat as a promising approach for burn and wound care, combining an early anaesthetic effect with sustained antimicrobial action.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Sewar Talal Ali Abuassi
0009-0001-1622-256X
Türkiye

Emine Kahraman ^*
0000-0001-5911-9151
Türkiye

Publication Date

January 14, 2026

Submission Date

May 5, 2025

Acceptance Date

July 22, 2025

Published in Issue

Year 2025 Volume: 55 Number: 3

DOI

https://doi.org/10.26650/IstanbulJPharm.2025.1691720

IZ

https://izlik.org/JA73HF49FU

Cite

RIS / Bibtex

APA

Abuassi, S. T. A., & Kahraman, E. (2026). Double-Layer Nanofibrous Mats Loaded with Lidocaine Hydrochloride and Silver Sulfadiazine: Physicochemical Characterization and in vitro Release Studies. İstanbul Journal of Pharmacy, 55(3), 366-377. https://doi.org/10.26650/IstanbulJPharm.2025.1691720

AMA

1.Abuassi STA, Kahraman E. Double-Layer Nanofibrous Mats Loaded with Lidocaine Hydrochloride and Silver Sulfadiazine: Physicochemical Characterization and in vitro Release Studies. iujp. 2026;55(3):366-377. doi:10.26650/IstanbulJPharm.2025.1691720

Chicago

Abuassi, Sewar Talal Ali, and Emine Kahraman. 2026. “Double-Layer Nanofibrous Mats Loaded With Lidocaine Hydrochloride and Silver Sulfadiazine: Physicochemical Characterization and in Vitro Release Studies”. İstanbul Journal of Pharmacy 55 (3): 366-77. https://doi.org/10.26650/IstanbulJPharm.2025.1691720.

EndNote

Abuassi STA, Kahraman E (January 1, 2026) Double-Layer Nanofibrous Mats Loaded with Lidocaine Hydrochloride and Silver Sulfadiazine: Physicochemical Characterization and in vitro Release Studies. İstanbul Journal of Pharmacy 55 3 366–377.

IEEE

[1]S. T. A. Abuassi and E. Kahraman, “Double-Layer Nanofibrous Mats Loaded with Lidocaine Hydrochloride and Silver Sulfadiazine: Physicochemical Characterization and in vitro Release Studies”, iujp, vol. 55, no. 3, pp. 366–377, Jan. 2026, doi: 10.26650/IstanbulJPharm.2025.1691720.

ISNAD

Abuassi, Sewar Talal Ali - Kahraman, Emine. “Double-Layer Nanofibrous Mats Loaded With Lidocaine Hydrochloride and Silver Sulfadiazine: Physicochemical Characterization and in Vitro Release Studies”. İstanbul Journal of Pharmacy 55/3 (January 1, 2026): 366-377. https://doi.org/10.26650/IstanbulJPharm.2025.1691720.

JAMA

1.Abuassi STA, Kahraman E. Double-Layer Nanofibrous Mats Loaded with Lidocaine Hydrochloride and Silver Sulfadiazine: Physicochemical Characterization and in vitro Release Studies. iujp. 2026;55:366–377.

MLA

Abuassi, Sewar Talal Ali, and Emine Kahraman. “Double-Layer Nanofibrous Mats Loaded With Lidocaine Hydrochloride and Silver Sulfadiazine: Physicochemical Characterization and in Vitro Release Studies”. İstanbul Journal of Pharmacy, vol. 55, no. 3, Jan. 2026, pp. 366-77, doi:10.26650/IstanbulJPharm.2025.1691720.

Vancouver

1.Sewar Talal Ali Abuassi, Emine Kahraman. Double-Layer Nanofibrous Mats Loaded with Lidocaine Hydrochloride and Silver Sulfadiazine: Physicochemical Characterization and in vitro Release Studies. iujp. 2026 Jan. 1;55(3):366-77. doi:10.26650/IstanbulJPharm.2025.1691720