Alkaloid profiling in Galanthus gracilis Celak. from western Turkey by GC/MS

Yıl 2018, Cilt: 48 Sayı: 3, 73 - 75, 01.12.2018

Çiğdem Karakoyun

Öz

DOI: 10.26650/IstanbulJPharm.2018.422525

Galanthus
L. is generally acknowledged as a valuable biological source due to its
Amaryllidaceae alkaloids with unusual chemical structures and a wide variety of
biological activities. Among these alkaloids, galanthamine is the first example
of their practical application in medicine as a potent and selective inhibitor
of the enzyme acetylcholinesterase, and already present on the market as a
therapeutic agent for Alzheimer’s disease. Lycorine is the main Amaryllidaceae
alkaloid deeply investigated for its biological activity for many years. In
this study the alkaloidal profile of G. gracilis collected from western Aegean
(Alankıyı/Bayındır) will be illustrated for the first time. GC-MS profiling was
carried out on the crude alkaloidal extract obtained from dried and powdered
plant material. 11 alkaloids were detected by GC-MS, including graciline,
demethylhomolycorine and tazettine as the major ones.

Anahtar Kelimeler

Galanthus gracilis, tazettine, graciline, demethylhomolycorine, Amaryllidaceae, tazettine

Kaynakça

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