Synthesis, characterization and biological activity studies on amide derivatives

Yıl 2018, Cilt: 48 Sayı: 3, 76 - 81, 01.12.2018

Sevda Türk Kadir Turan Seyhan Ulusoy Sevgi Karakuş Gülgün Boşgelmez-tınaz

Öz

DOI : 10.26650/IstanbulJPharm.2018.18007

In this study, with intent to find out novel anti-biofilm and antiviral agents, a series of amide derivatives were synthesized and their structures were elucidated by FT-IR and 1H-NMR and 13C-NMR and MS methods. And also, their purity were proven by TLC, HPLC and elemental analyses. And finally, the synthesized compounds were examined for their biofilm formation and swarming motility inhibitory activities in P. aeruginosa PA01. These compounds were found to reduce biofilm formation by 8.7-25.6% and swarming motility by 18.3-33.8% in P. aeruginosa PA01 at a concentration of 200 μM. Besides, all of the compounds were evaluated for their antiviral activity against influenza A viruses. The plaque inhibition assays indicated that compound 6 (N-(4-{[5-(ethylamino)-1,3,4-thiadiazol-2-yl]methyl}phenyl)-4- fluorobenzamide) has considerable inhibitory effect on influenza A virus plaque formation.

Anahtar Kelimeler

Synthesis, amide, anti-biofilm activity, swarming motility, influenza viruses, antiviral activity

Kaynakça

• Yang ZB, Hu DY, Zeng S, Song BA (2016) Novel hydrazone derivatives containing pyridine amide moiety: design, synthesis, and insecticidal activity. Bioorg Med Chem Lett 26: 1161-1164.