Background and Aims: In this study, simple, accurate and precise spectrophotometric methods were developed for the determination of five 3-hydroxy-3-methylglutaryl-coenzyme-A (HMG-CoA) reductase inhibitors in pure and pharmaceutical dosage forms. Methods: In the developed methods, atorvastatin fluvastatin, pitavastatin, rosuvastatin and simvastatin were used in this class of drugs called statins. The methods were based on the charge-transfer reaction of n-electron donor drugs with π-acceptor 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). All variables such as temperature, time, reaction medium, amount of reagent were examined for optimal formation of complexes to be given by the drugs with DDQ and optimal conditions were determined. Results: The linearity ranges for atorvastatin, fluvastatin, pitavastatin, rosuvastatin and simvastatin were found to be 0.5-50, 1-6, 2.5-50, 5-25 and 5-50 μg/mL, respectively. Conclusion: The proposed methods were successfully applied to both the pure and the pharmaceutical dosage forms
HMG-CoA reductase inhibitors spectrophotometric determination charge-transfer reaction DDQ pharmaceutical preparations
Birincil Dil | İngilizce |
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Konular | Eczacılık ve İlaç Bilimleri, Sağlık Kurumları Yönetimi |
Bölüm | Original Article |
Yazarlar | |
Yayımlanma Tarihi | 27 Ağustos 2020 |
Gönderilme Tarihi | 13 Şubat 2020 |
Yayımlandığı Sayı | Yıl 2020 Cilt: 50 Sayı: 2 |