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Yıl 2020, Cilt: 50 Sayı: 2, 149 - 152, 27.08.2020

Öz

Kaynakça

  • Calcaterra, A., & D’Acquarica I. (2018). The market of chiral drugs: Chiral switches versus de novo enantiomerically pure compounds Journal of Pharmaceutical and Biomedical Analysis, 147, 323–340.
  • Chen, Q., Jeong, S., Hwang, G., Kim, K., & Kang, J. (2008). Enantioselective determination of chlorpheniramine in various formulations by HPLC using carboxymethyl-β-cyclodextrin as a chiral additive. Archives of pharmacal research, 31, 523-529.
  • Fried, K. M., Young, A. E., Yasuda, U. S., & Wainer, I. W. (2001). The enantioselective determination of chlorpheniramine and its major metabolites in human plasma using chiral chromatography on a β-cyclodextrin chiral stationary phase and mass spectrometric detection. Journal of Pharmaceutical and Biomedical Analysis, 27, 479–488.
  • Granberg, R. A., & Rasmuson, A. C. (1999). Solubility of paracetamol in pure solvents. Journal of Chemical & Engineering Data, 44, 1391– 1395.
  • Hiep, B. T., Khanh, V., Hung, N. K., Thuillier, A., & Gimenez, F. (1998). Determination of enantiomers of chlorpheniramine and its main monodesmethyl metabolite in urine using achiral-chiral liquid chromatography. Journal of Chromatography B. 707, 235–240.
  • International Conference on Harmonization. ICH. 2005. Validation of Analytical Procedures: Text and Methodology Q2 R1. Geneva: International Conference on Harmonization. Available from: https://www.gmp-compliance.org/guidemgr/files/Q2(R1).pdf
  • Tagawa, M., Kano, M., Okamura, N., Higuchi, M., Matsuda, M., Mizuki, Y., Yanai, K. (2002). Differential cognitive effects of ebastine and (+)-chlorpheniramine in healthy subjects: Correlation between cognitive impairment and plasma drug concentration. British Journal of Clinical Pharmacology, 53, 296–304.
  • Tanda, G., Kopajtic, T. A., & Katz, J. L. (2008). Cocaine-like neurochemical effects of antihistaminic medications. Journal of Neuro- Chemistry, 106, 147–157.

Determination of chlorpheniramine enantiomers in pharmaceutical formulations by HPLC on chiral column with PDA detection

Yıl 2020, Cilt: 50 Sayı: 2, 149 - 152, 27.08.2020

Öz

Background and Aims: An HPLC method with photodiode array detector on a chiral column was proposed for enantioselective determination of chlorpheniramine (CLP) enantiomers in dosage forms. Methods: The enantioselective determination was achieved on amylose tris(3,5-dimethylphenylcarbamate) column, using n-hexane-(propan-2-ol)-diethylamine (97.5:2.5:0.025, v/v/v) mobile phase. The peaks were detected at 258 nm. Diphenhydramine was used as an internal standard (IS). A new sample preparation procedure was developed to avoid the interference of the other ingredients present in the formulations. Results: Limit of quantification of the proposed method was 0.88 and 1.31 μg/mL for S-(+)-CLP and R-(-)-CLP, respectively. Conclusion: The method is linear, sensitive, specific and can be used for the enantioselective assay of CLP enantiomers in pharmaceutical formulations.

Kaynakça

  • Calcaterra, A., & D’Acquarica I. (2018). The market of chiral drugs: Chiral switches versus de novo enantiomerically pure compounds Journal of Pharmaceutical and Biomedical Analysis, 147, 323–340.
  • Chen, Q., Jeong, S., Hwang, G., Kim, K., & Kang, J. (2008). Enantioselective determination of chlorpheniramine in various formulations by HPLC using carboxymethyl-β-cyclodextrin as a chiral additive. Archives of pharmacal research, 31, 523-529.
  • Fried, K. M., Young, A. E., Yasuda, U. S., & Wainer, I. W. (2001). The enantioselective determination of chlorpheniramine and its major metabolites in human plasma using chiral chromatography on a β-cyclodextrin chiral stationary phase and mass spectrometric detection. Journal of Pharmaceutical and Biomedical Analysis, 27, 479–488.
  • Granberg, R. A., & Rasmuson, A. C. (1999). Solubility of paracetamol in pure solvents. Journal of Chemical & Engineering Data, 44, 1391– 1395.
  • Hiep, B. T., Khanh, V., Hung, N. K., Thuillier, A., & Gimenez, F. (1998). Determination of enantiomers of chlorpheniramine and its main monodesmethyl metabolite in urine using achiral-chiral liquid chromatography. Journal of Chromatography B. 707, 235–240.
  • International Conference on Harmonization. ICH. 2005. Validation of Analytical Procedures: Text and Methodology Q2 R1. Geneva: International Conference on Harmonization. Available from: https://www.gmp-compliance.org/guidemgr/files/Q2(R1).pdf
  • Tagawa, M., Kano, M., Okamura, N., Higuchi, M., Matsuda, M., Mizuki, Y., Yanai, K. (2002). Differential cognitive effects of ebastine and (+)-chlorpheniramine in healthy subjects: Correlation between cognitive impairment and plasma drug concentration. British Journal of Clinical Pharmacology, 53, 296–304.
  • Tanda, G., Kopajtic, T. A., & Katz, J. L. (2008). Cocaine-like neurochemical effects of antihistaminic medications. Journal of Neuro- Chemistry, 106, 147–157.
Toplam 8 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık ve İlaç Bilimleri, Sağlık Kurumları Yönetimi
Bölüm Short Paper
Yazarlar

Gizem Erensoy Bu kişi benim 0000-0001-5991-4833

Duygu Taşkın Bu kişi benim 0000-0002-5279-0900

Gamze Özgül Artuç Bu kişi benim 0000-0002-7869-1281

Elif Özdemir Bu kişi benim 0000-0002-5011-8344

Sumru Özkırımlı Bu kişi benim 0000-0002-7939-2750

Yayımlanma Tarihi 27 Ağustos 2020
Gönderilme Tarihi 4 Aralık 2019
Yayımlandığı Sayı Yıl 2020 Cilt: 50 Sayı: 2

Kaynak Göster

APA Erensoy, G., Taşkın, D., Özgül Artuç, G., Özdemir, E., vd. (2020). Determination of chlorpheniramine enantiomers in pharmaceutical formulations by HPLC on chiral column with PDA detection. İstanbul Journal of Pharmacy, 50(2), 149-152.
AMA Erensoy G, Taşkın D, Özgül Artuç G, Özdemir E, Özkırımlı S. Determination of chlorpheniramine enantiomers in pharmaceutical formulations by HPLC on chiral column with PDA detection. iujp. Ağustos 2020;50(2):149-152.
Chicago Erensoy, Gizem, Duygu Taşkın, Gamze Özgül Artuç, Elif Özdemir, ve Sumru Özkırımlı. “Determination of Chlorpheniramine Enantiomers in Pharmaceutical Formulations by HPLC on Chiral Column With PDA Detection”. İstanbul Journal of Pharmacy 50, sy. 2 (Ağustos 2020): 149-52.
EndNote Erensoy G, Taşkın D, Özgül Artuç G, Özdemir E, Özkırımlı S (01 Ağustos 2020) Determination of chlorpheniramine enantiomers in pharmaceutical formulations by HPLC on chiral column with PDA detection. İstanbul Journal of Pharmacy 50 2 149–152.
IEEE G. Erensoy, D. Taşkın, G. Özgül Artuç, E. Özdemir, ve S. Özkırımlı, “Determination of chlorpheniramine enantiomers in pharmaceutical formulations by HPLC on chiral column with PDA detection”, iujp, c. 50, sy. 2, ss. 149–152, 2020.
ISNAD Erensoy, Gizem vd. “Determination of Chlorpheniramine Enantiomers in Pharmaceutical Formulations by HPLC on Chiral Column With PDA Detection”. İstanbul Journal of Pharmacy 50/2 (Ağustos 2020), 149-152.
JAMA Erensoy G, Taşkın D, Özgül Artuç G, Özdemir E, Özkırımlı S. Determination of chlorpheniramine enantiomers in pharmaceutical formulations by HPLC on chiral column with PDA detection. iujp. 2020;50:149–152.
MLA Erensoy, Gizem vd. “Determination of Chlorpheniramine Enantiomers in Pharmaceutical Formulations by HPLC on Chiral Column With PDA Detection”. İstanbul Journal of Pharmacy, c. 50, sy. 2, 2020, ss. 149-52.
Vancouver Erensoy G, Taşkın D, Özgül Artuç G, Özdemir E, Özkırımlı S. Determination of chlorpheniramine enantiomers in pharmaceutical formulations by HPLC on chiral column with PDA detection. iujp. 2020;50(2):149-52.