Araştırma Makalesi
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Yıl 2023, Cilt: 53 Sayı: 1, 30 - 38, 28.04.2023

Öz

Destekleyen Kurum

Çukurova üniversitesi

Proje Numarası

TSA-2019-11424

Kaynakça

  • Agrawal, A. K., Das, M., & Jain, S. (2012). In situ gel systems as ‘smart’ carriers for sustained ocular drug delivery. Expert Opinion on Drug Delivery, 9(4), 383-402.
  • Ahmadiani, A., Fereidoni, M., Semnanian, S., Kamalinejad, M., & Saremi, S. (1998). Antinociceptive and anti-inflammatory effects of Sambucus ebulus rhizome extract in rats. Journal of Ethnophar- macology, 61(3), 229-235.
  • Atay, I., Kirmizibekmez, H., Gören, A. C., & Yeşilada, E. (2015). Sec- ondary metabolites from Sambucus ebulus. Turkish Journal of Chemistry, 39(1), 34-41.
  • Aydın, A, Yeşil, Y. (2018). İkizce Ordu-Türkiye ilçesinde etnobotanik bir ön çalışma [An ethnobotanical preliminary study in İkizce (Or- du-Turkey) district]. Bağbahçe Bilim Dergisi, 5(3), 25-43 .
  • Bhattaccharjee, S., Beck-Broichsitter, M., & Banga, A. K. (2020). In situ gel formation in microporated skin for enhanced topical de- livery of niacinamide. Pharmaceutics, 12(5), 472.
  • Bozkurt, A. E., & Terzioğlu, S. (2017). The aromatic-medicinal plant taxa of pure scots pine stands in Sürmene-Camburnu (Trab- zon). International Journal of Secondary Metabolite, 4(3, Special Issue 2), 517-529.
  • Bradley, A. F., Loftsgaarden, D. O., & Steele, R. (1992). Constructing and testing logistic regression models for binary data: Applications to the National Fire Danger Rating System (pp. 284-287). US De- partment of Agriculture, Forest Service, Intermountain Research Station.
  • Charlebois, D., Byers, P. L., Finn, C. E., & Thomas, A. L. (2010). Elder- berry: Botany, Horticulture, Potential. Horticultural Reviews, 37(4), 214-280.
  • Chaudhary, B., & Verma, S. (2014). Preparation and evaluation of novel in situ gels containing acyclovir for the treatment of oral her- pes simplex virus infections. The Scientific World Journal, 2014, 1-7.
  • Chirigiu, L., Chirigiu, R. G., Tircomnicu, V., & Bubulica, M. V. (2011). GC-MS analysis of chemical composition of Sambucus ebulus leaves. Chemistry of natural compounds, 47(1), 126-127.
  • Choi, H. G., Jung, J. H., Ryu, J. M., Yoon, S. J., Oh, Y. K., & Kim, C. K. 36
  • (1998). Development of in situ-gelling and mucoadhesive acet- aminophen liquid suppository. International Journal of Pharma- ceutics, 165(1), 33-44.
  • Cvetanović, A. (2020). Sambucus ebulus L., antioxidants and poten- tial in disease. In Pathology (pp. 321-333). Academic Press.
  • Demirci, S., & Özhatay, N. (2012). An ethnobotanical study in Kahramanmaraş (Turkey); wild plants used for medicinal purpose in Andirin, Kahramanmaraş. Turk J Pharm Sci, 9(1), 75-92.
  • Ebrahimzadeh, M., Mahmoudi, M., & Salimi, E. (2006). Antiinflam- matory activity of Sambucus ebulus hexane extracts. Fitoterapia, 77(2), 146-148.
  • Eminağaoğlu, Ö., Göktürk, T., & Akyıldırım Beğen, H. A. Y. A. L. (2017). Traditional uses of medicinal plants and animals of Ha- tila Valley National Park, Artvin. Biological Diversity and Conserva- tion, 10(3), 33-42.
  • Erol, I., Üstündağ Okur, N., Orak, D., Sipahi, H., Aydın, A., & Özer, Ö. (2020). Tazarotene-loaded in situ gels for potential management of psoriasis: biocompatibility, anti-inflammatory and analgesic ef- fect. Pharmaceutical Development and Technology, 25(8), 909-918.
  • Göç, F., Mat, A. (2019). Türkiye’de Yanık Tedavisinde Geleneksel Olarak Kullanılan Bitkiler [Plants Traditionally Used in the Treat- ment of Burns in Turkey]. Journal of Advanced Research in Health Sciences, 2(1), 15-35.
  • Gugleva, V., Titeva, S., Ermenlieva, N., Tsibranska, S., Tcholakova, S., Rangelov, S., & Momekova, D. (2020). Development and evalu- ation of doxycycline niosomal thermoresponsive in situ gel for ophthalmic delivery. International Journal of Pharmaceutics, 591, 1-11.
  • Gül, V., & Dİnler, B. S. (2016). Some medical and aromatic plants growing naturally in Kumru Region (Ordu). Ziraat Fakültesi Dergisi- Süleyman Demirel Üniversitesi, 11(1), 146-156.
  • Güner, Ö., Selvi, S. (2016). Balıkesir aktarlarında satılan yabani tıbbi bitkiler ve kullanım özellikleri [Wild medicinal plants sold in Balıkesir/Turkey herbal markets and their using properties]. Bio- logical Diversity and Conservation, 9(2), 96-101 .
  • Güneş, F. (2018). Edirne’nin İpsala ilçesinde halk ilacı olarak kullanılan bitkiler. Research Journal of Biology Sciences, 11(1), 29-37.
  • Güneş, S., Savran, A., Paksoy, M. Y., Koşar, M., & Çakılcıoğlu, U. (2017). Ethnopharmacological survey of medicinal plants in Karaisalı and its surrounding (Adana-Turkey). Journal of Herbal Medicine, 8, 68-75.
  • Güngör, S., Erdal, M. F., & Aksu, B. (2013). New Formulation Strate- gies in Topical Antifungal Therapy. Journal of Cosmetics. Derma- tological Sciences and Applications, 3, 56-65.
  • Güven, U. M., Berkman, M. S., Şenel, B., & Yazan, Y. (2019). Develop- ment and in vitro/in vivo evaluation of thermo-sensitive in situ gelling systems for ocular allergy. Brazilian Journal of Pharmaceuti- cal Sciences, 55.
  • Hashemi, Z., Ebrahimzadeh, M. A., & Khalili, M. (2019). Sun pro- tection factor, total phenol, flavonoid contents and antioxidant activity of medicinal plants from Iran. Trop. J. Pharm. Res, 18, 1443- 1448.
  • Hudson, S. P., Langer, R., Fink, G. R., & Kohane, D. S. (2010). Inject- able in situ cross-linking hydrogels for local antifungal therapy. Biomaterials, 31(6), 1444-1452.
  • Ivanova, D., Tasinov, O., & Kiselova-Kaneva, Y. (2014). Improved lipid profile and increased serum antioxidant capacity in healthy volunteers after Sambucus ebulus L. fruit infusion consumption. International journal of food sciences and nutrition, 65(6), 740-744.
  • Jabbari, M., Daneshfard, B., Emtiazy, M., Khiveh, A., & Hashempur,
  • M. H. (2017). Biological effects and clinical applications of dwarf elder (Sambucus ebulus L): A review. Journal of evidence-based complementary & alternative medicine, 22(4), 996-1001.
  • Kaileh, M., Berghe, W. V., Boone, E., Essawi, T., & Haegeman, G. (2007). Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity. Journal of eth- nopharmacology, 113(3), 510-516.
  • Kang, F., & Singh, J. (2005). In vitro release of insulin and biocom- patibility of in situ forming gel systems. International Journal of Pharmaceutics, 304(1-2), 83-90.
  • Karaköse, M., & Karaköse, G. Ç. (2017). Medicinal and Aromatic Plants of Esenli (Giresun) Forest Planning Unit. International Jour- nal of Secondary Metabolite, 4(3), 285-305.
  • Karcı, E., Gürbüz, İ., Akaydın, G., & Günbatan, T. (2017). Folk medi- cines of Bafra (Samsun-Turkey). Turkish Journal of Biochemis- try, 42(4), 381-399.
  • Kaveh, K., Mohamadyan, M., & Ebrahimzadeh, M. A. (2019). Anti- hypoxic activities of sambucus ebulus leaf and fruit and myrtus communis leaf in mice. Journal of Mazandaran University of Medi- cal Sciences, 29(176), 61-73.
  • Kaya, Y., Haji, E. K., Arvas, Y.E., & Aksoy, H. M. (2019). Sambucus ebu- lus L.: Past, present and future. Paper presented at the AIP Confer- ence Proceedings. AIP Publishing LLC.
  • Khode, P.D., & Dongare, P.A. (2019). In situ gel: A Review of Pharma- ceutical and Biological Evaluation and Approaches. Research Jour- nal of Pharmaceutical Dosage Forms and Technology, 11(3), 217-226.
  • Khule, M. R., & Vyavahare, S.B. (2021). A Review: In-Situ gel drug delivery system. Int. J. Res. Education and Scientific methods, 9(3), 899-909.
  • Kizilarslan H. Ç. (2012). An ethnobotanical study of the useful and edible plants of Izmit. Marmara Pharmaceutcal Journal, 3,194-200.
  • Koyuncu, O., Yaylacı, Ö. K., & Tokur, S. (2009). Geyve (Sakarya) ve çevresinin etnobotanik açıdan incelenmesi [A Study on Geyve (Sakarya) and its Environs in Terms of Ethnobotanical Aspects]. Ot Sistematik Botanik Dergisi, 16(1), 123-142.
  • Kültür, Ş. (2007). Medicinal plants used in Kırklareli province (Tur- key). Journal of ethnopharmacology, 111(2), 341-364.
  • Liu, X., Gan, H., Hu, C., Sun, W., Zhu, X., Meng, Z., ... & Dou, G. (2019). Silver sulfadiazine nanosuspension-loaded thermosensitive hy- drogel as a topical antibacterial agent. International journal of nanomedicine, 14, 289.
  • Mahboubi, M. (2020). Sambucus nigra (black elder) as alternative treatment for cold and flu. Advances in Traditional Medicine, 1-10.
  • Mandal, S., Thimmasetty, M. K., Prabhushankar, G. L., & Geetha, M. S. (2012). Formulation and evaluation of an in situ gel-forming ophthalmic formulation of moxifloxacin hydrochloride. Interna- tional journal of pharmaceutical investigation, 2(2), 78.
  • Melikoğlu, G., Kurtoğlu, S., & Kültür, Ş. (2015). Türkiye’de astım te- davisinde geleneksel olarak kullanılan bitkiler. Marmara Pharma- ceutical Journal, 19(1), 1-11.
  • Nirmal H. B., Bakliwal S. R., & Pawar, S. P. (2010). In-situ gel: new trends in controlled and sustained drug delivery system. Interna- tional Journal of PharmTech Research, 2(2), 1398-408.
  • Niyompanich, J., Chuysinuan, P., Pavasant, P., & Supaphol, P. (2021). Development of thermoresponsive poloxamer in situ gel loaded with gentamicin sulfate for cavity wounds. Journal of Polymer Re- search, 28(4), 1-13.
  • Öz, U. C., Toptaş, M., Küçüktürkmen, B., Devrim, B., Saka, O. M., Deveci, M. S. Bozkır, A. (2020). Guided bone regeneration by the development of alendronate sodium loaded in-situ gel and membrane formulations. European Journal of Pharmaceutical Sci- ences, 155, 105561.
  • Passalacqua, N. G., Guarrera, P. M., & De Fine, G. (2007). Contribu- tion to the knowledge of the folk plant medicine in Calabria re- gion (Southern Italy). Fitoterapia, 78(1), 52-68.
  • Pieroni, A., Giusti, M. E., Münz, H., Lenzarini, C., Turković, G., & Turković, A. (2003). Ethnobotanical knowledge of the Istro-Roma- nians of Žejane in Croatia. Fitoterapia, 74(7-8), 710-719.
  • Popović, Z., Matić, R., Stefanović, M., Vidaković, V., & Bojović, S. (2020). Biodiversity of wild fruits with medicinal potential in Ser- bia. In Biodiversity and Biomedicine (pp. 161-188). Academic Press.
  • Rençber, S., Karavana, S. Y., Şenyiğit, Z. A., Eraç, B., Limoncu, M. H., & Baloğlu, E. (2017). Mucoadhesive in situ gel formulation for vaginal delivery of clotrimazole: formulation, preparation, and in vitro/in vivo evaluation. Pharmaceutical Development and Tech- nology, 22(4), 551-561.
  • Rezaei-Moshaei, M., Dehestani, A., Bandehagh, A., Pakdin-Parizi, A., Golkar, M., & Heidari-Japelaghi, R. (2021). Recombinant pebu- lin protein, a type 2 ribosome-inactivating protein isolated from dwarf elder (Sambucus ebulus L.) shows anticancer and antifun- gal activities in vitro. International Journal of Biological Macromol- ecules, 174, 352-361.
  • Rigat, M., D’Ambrosio, U., Garnatje, T., Gras, A., Parada, M., & Val- lès, J. (2018). Sambucus ebulus L. Inventario Español de los Cono- cimientos Tradicionales relativos a la Biodiversidad, 137-140.
  • Rodino, S., Butu, A., Petrache, P. E. T. R. U. Ț. A., Butu, M., Dinu-Pirvu, C. E., & Cornea, C. P. (2015). Evaluation of the antimicrobial and antioxidant activity of Sambucus ebulus extract. Farmacia, 63(5), 751-4.
  • Sağıroğlu, M., Arslantürk, A., Akdemir, Z. K., & Turna, M. (2012). An ethnobotanical survey from Hayrat Trabzon and Kalkandere Rize/ Turkey. Biological Diversity and Conservation, 5(1), 31-42.
  • Salatin, S., Lotfipour, F., & Jelvehgari, M. (2020). Preparation and characterization of a novel thermosensitive and bioadhesive cephalexin nanohydrogel: A promising platform for topical anti- bacterial delivery. Expert Opinion on Drug Delivery, 17(6), 881-893.
  • Salehzadeh, A., Asadpour, L., Naeemi, A. S., & Houshmand, E. (2014). Antimicrobial activity of methanolic extracts of Sambu- cus ebulus and Urtica dioica against clinical isolates of methicil- lin resistant Staphylococcus aureus. African Journal of Traditional, Complementary and Alternative Medicines, 11(5), 38-40.
  • Saraç, D. U. (2013). Ethnobotanic features of Rize province (Doctoral dissertation, MSc Thesis. Forest Engineering Graduate Program, Karadeniz Technical University, Trabzon).
  • Scopel, M., Nunes, E. C. M., Silva, M. V., Vendruscolo, G. S., Henriques, A. T., & Mentz, L. A. (2007). Caracterização farmacobotânica das es- pécies de Sambucus (Caprifoliaceae) utilizadas como medicinais no Brasil: Parte I. Sambucus nigra L. Revista brasileira de farmacognosia. São Paulo, SP. Vol. 17, n. 2 (Abr./Jun. 2007), p. 249-261.
  • Senica, M., Stampar, F., & Mikulic-Petkovsek, M. (2019). Harmful (cyanogenic glycoside) and beneficial (phenolic) compounds in different Sambucus species. Journal of Berry Research, 9(3), 395-409.
  • Shokrzadeh, M., & Saravi, S. S. (2010). The chemistry, pharmacol- ogy and clinical properties of Sambucus ebulus: A review. Journal of medicinal plants research, 4(2), 095-103.
  • Süntar, I. P., Akkol, E. K., Yalçın, F. N., Koca, U., Keleş, H., & Yesilada, E. (2010). Wound healing potential of Sambucus ebulus L. leaves and isolation of an active component, quercetin 3-O-glucoside. Journal of ethnopharmacology, 129(1), 106-114.
  • Tuzlaci, E. (2015). An ethnobotanical study of medicinal plants in bayramiç (Çanakkale-Turkey). Marmara Pharmaceutical Journal, 19, 268-282.
  • Tuzlacı, E., & Tolon, E. (2000). Turkish folk medicinal plants, part III: Şile (Istanbul). Fitoterapia, 71(6), 673-685.
  • Okur, N. Ü., Yoltaş, A., & Yozgatlı, V. (2016). Development and characterization of voriconazole loaded in situ gel formulations for ophthalmic application. Turkish Journal of Pharmaceutical Sci- ences, 13(3), 311-317.
  • Vallès, J., Bonet, M. À., & Agelet, A. (2004). Ethnobotany of Sam- bucus nigra L. in Catalonia (Iberian Peninsula): the integral ex- ploitation of a natural resource in mountain regions. Economic Botany, 58(3), 456-469.
  • Wichtl, M., & Bisset, N. G. (1994). Herbal drugs and phytopharma- ceuticals. Medpharm. GmbH Scientific publishers, Birkenwaldstras- se, 44, 650-652.
  • Xie, M. H., Ge, M., Peng, J. B., Jiang, X. R., Wang, D. S., Ji, L. Q & Wang, Z. (2019). In-vivo anti-tumor activity of a novel poloxamer-based thermosensitive in situ gel for sustained delivery of norcantharidin. Pharmaceutical Development and Technology, 24(5), 623-629.
  • Yara, P. İ. I. S. J. (2019). Evaluation of in situ gel containing pycno- genol for cutaneous wound healing. Medeniyet Medical Journal, 34(1), 67-75.
  • Yesilada, E. (1997). Evaluation of the anti-inflammatory activity of the Turkish medicinal plant Sambucus ebulus. Chemistry of Natural Compounds, 33(5), 539-540.
  • Yesilada, E., Gürbüz, İ., & Toker, G. (2014). Anti-ulcerogenic activ- ity and isolation of the active principles from Sambucus ebulus L. leaves. Journal of Ethnopharmacology, 153(2), 478-483.
  • Yeşilada, E., Sezik, E., Honda, G., Takaishi, Y., Takeda, Y., & Tanaka, T. (1999). Traditional medicine in Turkey IX: Folk medicine in north- west Anatolia. Journal of Ethnopharmacology, 64(3), 195-210.
  • Yuan, Y., Cui, Y., Zhang, L., Zhu, H. P., Guo, Y. S., Zhong, B., ... & Chen, L. (2012). Thermosensitive and mucoadhesive in situ gel based on poloxamer as new carrier for rectal administration of nime- sulide. International Journal of Pharmaceutics, 430(1-2), 114-119.
  • Zahmanov, G., Alipieva, K., Denev, P., Todorov, D., Hinkov, A., Shish- kov, S. Georgiev, M. I. (2015). Flavonoid glycosides profiling in dwarf elder fruits (Sambucus ebulus L.) and evaluation of their an- tioxidant and anti-herpes simplex activities. Industrial Crops and Products, 63, 58-64.

Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract

Yıl 2023, Cilt: 53 Sayı: 1, 30 - 38, 28.04.2023

Öz

Background and Aims: Sambucus ebulus L. has been used to treat inflammation-related gastrointestinal disorders, influen- za, kidney ailments, lung diseases, rheumatoid arthritis, and snake and insect bites. Our study provides important ethnobo- tanical information about S. ebulus with the aim of developing a formulation with increased extract bioavailability, diminished side effects, and easy drug loading and dose adjustment as an effective local therapy for dermatologic diseases.
Methods: Twelve in-situ gels with S. ebulus were prepared as antifungal treatments in accordance with the cold method and formulated using poloxamer and hydroxypropyl methylcellulose (HPMC). The formulations were characterized in terms of pH, gelling capacity, swelling degree, spreadability, and rheological properties.
Results: Among the prepared in situ gel formulations, the Poloxamer 407 and 407-HPMC mixtures of P14H1 and P15 demon- strated acceptable gelation temperatures for dermal use.
Conclusion: Thermosensitive in-situ gels containing S. ebulus may be a viable alternative for treating fungal diseases.

Proje Numarası

TSA-2019-11424

Kaynakça

  • Agrawal, A. K., Das, M., & Jain, S. (2012). In situ gel systems as ‘smart’ carriers for sustained ocular drug delivery. Expert Opinion on Drug Delivery, 9(4), 383-402.
  • Ahmadiani, A., Fereidoni, M., Semnanian, S., Kamalinejad, M., & Saremi, S. (1998). Antinociceptive and anti-inflammatory effects of Sambucus ebulus rhizome extract in rats. Journal of Ethnophar- macology, 61(3), 229-235.
  • Atay, I., Kirmizibekmez, H., Gören, A. C., & Yeşilada, E. (2015). Sec- ondary metabolites from Sambucus ebulus. Turkish Journal of Chemistry, 39(1), 34-41.
  • Aydın, A, Yeşil, Y. (2018). İkizce Ordu-Türkiye ilçesinde etnobotanik bir ön çalışma [An ethnobotanical preliminary study in İkizce (Or- du-Turkey) district]. Bağbahçe Bilim Dergisi, 5(3), 25-43 .
  • Bhattaccharjee, S., Beck-Broichsitter, M., & Banga, A. K. (2020). In situ gel formation in microporated skin for enhanced topical de- livery of niacinamide. Pharmaceutics, 12(5), 472.
  • Bozkurt, A. E., & Terzioğlu, S. (2017). The aromatic-medicinal plant taxa of pure scots pine stands in Sürmene-Camburnu (Trab- zon). International Journal of Secondary Metabolite, 4(3, Special Issue 2), 517-529.
  • Bradley, A. F., Loftsgaarden, D. O., & Steele, R. (1992). Constructing and testing logistic regression models for binary data: Applications to the National Fire Danger Rating System (pp. 284-287). US De- partment of Agriculture, Forest Service, Intermountain Research Station.
  • Charlebois, D., Byers, P. L., Finn, C. E., & Thomas, A. L. (2010). Elder- berry: Botany, Horticulture, Potential. Horticultural Reviews, 37(4), 214-280.
  • Chaudhary, B., & Verma, S. (2014). Preparation and evaluation of novel in situ gels containing acyclovir for the treatment of oral her- pes simplex virus infections. The Scientific World Journal, 2014, 1-7.
  • Chirigiu, L., Chirigiu, R. G., Tircomnicu, V., & Bubulica, M. V. (2011). GC-MS analysis of chemical composition of Sambucus ebulus leaves. Chemistry of natural compounds, 47(1), 126-127.
  • Choi, H. G., Jung, J. H., Ryu, J. M., Yoon, S. J., Oh, Y. K., & Kim, C. K. 36
  • (1998). Development of in situ-gelling and mucoadhesive acet- aminophen liquid suppository. International Journal of Pharma- ceutics, 165(1), 33-44.
  • Cvetanović, A. (2020). Sambucus ebulus L., antioxidants and poten- tial in disease. In Pathology (pp. 321-333). Academic Press.
  • Demirci, S., & Özhatay, N. (2012). An ethnobotanical study in Kahramanmaraş (Turkey); wild plants used for medicinal purpose in Andirin, Kahramanmaraş. Turk J Pharm Sci, 9(1), 75-92.
  • Ebrahimzadeh, M., Mahmoudi, M., & Salimi, E. (2006). Antiinflam- matory activity of Sambucus ebulus hexane extracts. Fitoterapia, 77(2), 146-148.
  • Eminağaoğlu, Ö., Göktürk, T., & Akyıldırım Beğen, H. A. Y. A. L. (2017). Traditional uses of medicinal plants and animals of Ha- tila Valley National Park, Artvin. Biological Diversity and Conserva- tion, 10(3), 33-42.
  • Erol, I., Üstündağ Okur, N., Orak, D., Sipahi, H., Aydın, A., & Özer, Ö. (2020). Tazarotene-loaded in situ gels for potential management of psoriasis: biocompatibility, anti-inflammatory and analgesic ef- fect. Pharmaceutical Development and Technology, 25(8), 909-918.
  • Göç, F., Mat, A. (2019). Türkiye’de Yanık Tedavisinde Geleneksel Olarak Kullanılan Bitkiler [Plants Traditionally Used in the Treat- ment of Burns in Turkey]. Journal of Advanced Research in Health Sciences, 2(1), 15-35.
  • Gugleva, V., Titeva, S., Ermenlieva, N., Tsibranska, S., Tcholakova, S., Rangelov, S., & Momekova, D. (2020). Development and evalu- ation of doxycycline niosomal thermoresponsive in situ gel for ophthalmic delivery. International Journal of Pharmaceutics, 591, 1-11.
  • Gül, V., & Dİnler, B. S. (2016). Some medical and aromatic plants growing naturally in Kumru Region (Ordu). Ziraat Fakültesi Dergisi- Süleyman Demirel Üniversitesi, 11(1), 146-156.
  • Güner, Ö., Selvi, S. (2016). Balıkesir aktarlarında satılan yabani tıbbi bitkiler ve kullanım özellikleri [Wild medicinal plants sold in Balıkesir/Turkey herbal markets and their using properties]. Bio- logical Diversity and Conservation, 9(2), 96-101 .
  • Güneş, F. (2018). Edirne’nin İpsala ilçesinde halk ilacı olarak kullanılan bitkiler. Research Journal of Biology Sciences, 11(1), 29-37.
  • Güneş, S., Savran, A., Paksoy, M. Y., Koşar, M., & Çakılcıoğlu, U. (2017). Ethnopharmacological survey of medicinal plants in Karaisalı and its surrounding (Adana-Turkey). Journal of Herbal Medicine, 8, 68-75.
  • Güngör, S., Erdal, M. F., & Aksu, B. (2013). New Formulation Strate- gies in Topical Antifungal Therapy. Journal of Cosmetics. Derma- tological Sciences and Applications, 3, 56-65.
  • Güven, U. M., Berkman, M. S., Şenel, B., & Yazan, Y. (2019). Develop- ment and in vitro/in vivo evaluation of thermo-sensitive in situ gelling systems for ocular allergy. Brazilian Journal of Pharmaceuti- cal Sciences, 55.
  • Hashemi, Z., Ebrahimzadeh, M. A., & Khalili, M. (2019). Sun pro- tection factor, total phenol, flavonoid contents and antioxidant activity of medicinal plants from Iran. Trop. J. Pharm. Res, 18, 1443- 1448.
  • Hudson, S. P., Langer, R., Fink, G. R., & Kohane, D. S. (2010). Inject- able in situ cross-linking hydrogels for local antifungal therapy. Biomaterials, 31(6), 1444-1452.
  • Ivanova, D., Tasinov, O., & Kiselova-Kaneva, Y. (2014). Improved lipid profile and increased serum antioxidant capacity in healthy volunteers after Sambucus ebulus L. fruit infusion consumption. International journal of food sciences and nutrition, 65(6), 740-744.
  • Jabbari, M., Daneshfard, B., Emtiazy, M., Khiveh, A., & Hashempur,
  • M. H. (2017). Biological effects and clinical applications of dwarf elder (Sambucus ebulus L): A review. Journal of evidence-based complementary & alternative medicine, 22(4), 996-1001.
  • Kaileh, M., Berghe, W. V., Boone, E., Essawi, T., & Haegeman, G. (2007). Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity. Journal of eth- nopharmacology, 113(3), 510-516.
  • Kang, F., & Singh, J. (2005). In vitro release of insulin and biocom- patibility of in situ forming gel systems. International Journal of Pharmaceutics, 304(1-2), 83-90.
  • Karaköse, M., & Karaköse, G. Ç. (2017). Medicinal and Aromatic Plants of Esenli (Giresun) Forest Planning Unit. International Jour- nal of Secondary Metabolite, 4(3), 285-305.
  • Karcı, E., Gürbüz, İ., Akaydın, G., & Günbatan, T. (2017). Folk medi- cines of Bafra (Samsun-Turkey). Turkish Journal of Biochemis- try, 42(4), 381-399.
  • Kaveh, K., Mohamadyan, M., & Ebrahimzadeh, M. A. (2019). Anti- hypoxic activities of sambucus ebulus leaf and fruit and myrtus communis leaf in mice. Journal of Mazandaran University of Medi- cal Sciences, 29(176), 61-73.
  • Kaya, Y., Haji, E. K., Arvas, Y.E., & Aksoy, H. M. (2019). Sambucus ebu- lus L.: Past, present and future. Paper presented at the AIP Confer- ence Proceedings. AIP Publishing LLC.
  • Khode, P.D., & Dongare, P.A. (2019). In situ gel: A Review of Pharma- ceutical and Biological Evaluation and Approaches. Research Jour- nal of Pharmaceutical Dosage Forms and Technology, 11(3), 217-226.
  • Khule, M. R., & Vyavahare, S.B. (2021). A Review: In-Situ gel drug delivery system. Int. J. Res. Education and Scientific methods, 9(3), 899-909.
  • Kizilarslan H. Ç. (2012). An ethnobotanical study of the useful and edible plants of Izmit. Marmara Pharmaceutcal Journal, 3,194-200.
  • Koyuncu, O., Yaylacı, Ö. K., & Tokur, S. (2009). Geyve (Sakarya) ve çevresinin etnobotanik açıdan incelenmesi [A Study on Geyve (Sakarya) and its Environs in Terms of Ethnobotanical Aspects]. Ot Sistematik Botanik Dergisi, 16(1), 123-142.
  • Kültür, Ş. (2007). Medicinal plants used in Kırklareli province (Tur- key). Journal of ethnopharmacology, 111(2), 341-364.
  • Liu, X., Gan, H., Hu, C., Sun, W., Zhu, X., Meng, Z., ... & Dou, G. (2019). Silver sulfadiazine nanosuspension-loaded thermosensitive hy- drogel as a topical antibacterial agent. International journal of nanomedicine, 14, 289.
  • Mahboubi, M. (2020). Sambucus nigra (black elder) as alternative treatment for cold and flu. Advances in Traditional Medicine, 1-10.
  • Mandal, S., Thimmasetty, M. K., Prabhushankar, G. L., & Geetha, M. S. (2012). Formulation and evaluation of an in situ gel-forming ophthalmic formulation of moxifloxacin hydrochloride. Interna- tional journal of pharmaceutical investigation, 2(2), 78.
  • Melikoğlu, G., Kurtoğlu, S., & Kültür, Ş. (2015). Türkiye’de astım te- davisinde geleneksel olarak kullanılan bitkiler. Marmara Pharma- ceutical Journal, 19(1), 1-11.
  • Nirmal H. B., Bakliwal S. R., & Pawar, S. P. (2010). In-situ gel: new trends in controlled and sustained drug delivery system. Interna- tional Journal of PharmTech Research, 2(2), 1398-408.
  • Niyompanich, J., Chuysinuan, P., Pavasant, P., & Supaphol, P. (2021). Development of thermoresponsive poloxamer in situ gel loaded with gentamicin sulfate for cavity wounds. Journal of Polymer Re- search, 28(4), 1-13.
  • Öz, U. C., Toptaş, M., Küçüktürkmen, B., Devrim, B., Saka, O. M., Deveci, M. S. Bozkır, A. (2020). Guided bone regeneration by the development of alendronate sodium loaded in-situ gel and membrane formulations. European Journal of Pharmaceutical Sci- ences, 155, 105561.
  • Passalacqua, N. G., Guarrera, P. M., & De Fine, G. (2007). Contribu- tion to the knowledge of the folk plant medicine in Calabria re- gion (Southern Italy). Fitoterapia, 78(1), 52-68.
  • Pieroni, A., Giusti, M. E., Münz, H., Lenzarini, C., Turković, G., & Turković, A. (2003). Ethnobotanical knowledge of the Istro-Roma- nians of Žejane in Croatia. Fitoterapia, 74(7-8), 710-719.
  • Popović, Z., Matić, R., Stefanović, M., Vidaković, V., & Bojović, S. (2020). Biodiversity of wild fruits with medicinal potential in Ser- bia. In Biodiversity and Biomedicine (pp. 161-188). Academic Press.
  • Rençber, S., Karavana, S. Y., Şenyiğit, Z. A., Eraç, B., Limoncu, M. H., & Baloğlu, E. (2017). Mucoadhesive in situ gel formulation for vaginal delivery of clotrimazole: formulation, preparation, and in vitro/in vivo evaluation. Pharmaceutical Development and Tech- nology, 22(4), 551-561.
  • Rezaei-Moshaei, M., Dehestani, A., Bandehagh, A., Pakdin-Parizi, A., Golkar, M., & Heidari-Japelaghi, R. (2021). Recombinant pebu- lin protein, a type 2 ribosome-inactivating protein isolated from dwarf elder (Sambucus ebulus L.) shows anticancer and antifun- gal activities in vitro. International Journal of Biological Macromol- ecules, 174, 352-361.
  • Rigat, M., D’Ambrosio, U., Garnatje, T., Gras, A., Parada, M., & Val- lès, J. (2018). Sambucus ebulus L. Inventario Español de los Cono- cimientos Tradicionales relativos a la Biodiversidad, 137-140.
  • Rodino, S., Butu, A., Petrache, P. E. T. R. U. Ț. A., Butu, M., Dinu-Pirvu, C. E., & Cornea, C. P. (2015). Evaluation of the antimicrobial and antioxidant activity of Sambucus ebulus extract. Farmacia, 63(5), 751-4.
  • Sağıroğlu, M., Arslantürk, A., Akdemir, Z. K., & Turna, M. (2012). An ethnobotanical survey from Hayrat Trabzon and Kalkandere Rize/ Turkey. Biological Diversity and Conservation, 5(1), 31-42.
  • Salatin, S., Lotfipour, F., & Jelvehgari, M. (2020). Preparation and characterization of a novel thermosensitive and bioadhesive cephalexin nanohydrogel: A promising platform for topical anti- bacterial delivery. Expert Opinion on Drug Delivery, 17(6), 881-893.
  • Salehzadeh, A., Asadpour, L., Naeemi, A. S., & Houshmand, E. (2014). Antimicrobial activity of methanolic extracts of Sambu- cus ebulus and Urtica dioica against clinical isolates of methicil- lin resistant Staphylococcus aureus. African Journal of Traditional, Complementary and Alternative Medicines, 11(5), 38-40.
  • Saraç, D. U. (2013). Ethnobotanic features of Rize province (Doctoral dissertation, MSc Thesis. Forest Engineering Graduate Program, Karadeniz Technical University, Trabzon).
  • Scopel, M., Nunes, E. C. M., Silva, M. V., Vendruscolo, G. S., Henriques, A. T., & Mentz, L. A. (2007). Caracterização farmacobotânica das es- pécies de Sambucus (Caprifoliaceae) utilizadas como medicinais no Brasil: Parte I. Sambucus nigra L. Revista brasileira de farmacognosia. São Paulo, SP. Vol. 17, n. 2 (Abr./Jun. 2007), p. 249-261.
  • Senica, M., Stampar, F., & Mikulic-Petkovsek, M. (2019). Harmful (cyanogenic glycoside) and beneficial (phenolic) compounds in different Sambucus species. Journal of Berry Research, 9(3), 395-409.
  • Shokrzadeh, M., & Saravi, S. S. (2010). The chemistry, pharmacol- ogy and clinical properties of Sambucus ebulus: A review. Journal of medicinal plants research, 4(2), 095-103.
  • Süntar, I. P., Akkol, E. K., Yalçın, F. N., Koca, U., Keleş, H., & Yesilada, E. (2010). Wound healing potential of Sambucus ebulus L. leaves and isolation of an active component, quercetin 3-O-glucoside. Journal of ethnopharmacology, 129(1), 106-114.
  • Tuzlaci, E. (2015). An ethnobotanical study of medicinal plants in bayramiç (Çanakkale-Turkey). Marmara Pharmaceutical Journal, 19, 268-282.
  • Tuzlacı, E., & Tolon, E. (2000). Turkish folk medicinal plants, part III: Şile (Istanbul). Fitoterapia, 71(6), 673-685.
  • Okur, N. Ü., Yoltaş, A., & Yozgatlı, V. (2016). Development and characterization of voriconazole loaded in situ gel formulations for ophthalmic application. Turkish Journal of Pharmaceutical Sci- ences, 13(3), 311-317.
  • Vallès, J., Bonet, M. À., & Agelet, A. (2004). Ethnobotany of Sam- bucus nigra L. in Catalonia (Iberian Peninsula): the integral ex- ploitation of a natural resource in mountain regions. Economic Botany, 58(3), 456-469.
  • Wichtl, M., & Bisset, N. G. (1994). Herbal drugs and phytopharma- ceuticals. Medpharm. GmbH Scientific publishers, Birkenwaldstras- se, 44, 650-652.
  • Xie, M. H., Ge, M., Peng, J. B., Jiang, X. R., Wang, D. S., Ji, L. Q & Wang, Z. (2019). In-vivo anti-tumor activity of a novel poloxamer-based thermosensitive in situ gel for sustained delivery of norcantharidin. Pharmaceutical Development and Technology, 24(5), 623-629.
  • Yara, P. İ. I. S. J. (2019). Evaluation of in situ gel containing pycno- genol for cutaneous wound healing. Medeniyet Medical Journal, 34(1), 67-75.
  • Yesilada, E. (1997). Evaluation of the anti-inflammatory activity of the Turkish medicinal plant Sambucus ebulus. Chemistry of Natural Compounds, 33(5), 539-540.
  • Yesilada, E., Gürbüz, İ., & Toker, G. (2014). Anti-ulcerogenic activ- ity and isolation of the active principles from Sambucus ebulus L. leaves. Journal of Ethnopharmacology, 153(2), 478-483.
  • Yeşilada, E., Sezik, E., Honda, G., Takaishi, Y., Takeda, Y., & Tanaka, T. (1999). Traditional medicine in Turkey IX: Folk medicine in north- west Anatolia. Journal of Ethnopharmacology, 64(3), 195-210.
  • Yuan, Y., Cui, Y., Zhang, L., Zhu, H. P., Guo, Y. S., Zhong, B., ... & Chen, L. (2012). Thermosensitive and mucoadhesive in situ gel based on poloxamer as new carrier for rectal administration of nime- sulide. International Journal of Pharmaceutics, 430(1-2), 114-119.
  • Zahmanov, G., Alipieva, K., Denev, P., Todorov, D., Hinkov, A., Shish- kov, S. Georgiev, M. I. (2015). Flavonoid glycosides profiling in dwarf elder fruits (Sambucus ebulus L.) and evaluation of their an- tioxidant and anti-herpes simplex activities. Industrial Crops and Products, 63, 58-64.
Toplam 75 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık ve İlaç Bilimleri
Bölüm Original Article
Yazarlar

Umay Merve Güven 0000-0003-1547-0817

Yusuf Yakut 0000-0003-0992-9986

Nurdan Çakır 0000-0001-8559-2305

Serpil Demirci Kayıran 0000-0001-8340-3347

Proje Numarası TSA-2019-11424
Yayımlanma Tarihi 28 Nisan 2023
Gönderilme Tarihi 1 Şubat 2022
Yayımlandığı Sayı Yıl 2023 Cilt: 53 Sayı: 1

Kaynak Göster

APA Güven, U. M., Yakut, Y., Çakır, N., Demirci Kayıran, S. (2023). Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract. İstanbul Journal of Pharmacy, 53(1), 30-38.
AMA Güven UM, Yakut Y, Çakır N, Demirci Kayıran S. Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract. iujp. Nisan 2023;53(1):30-38.
Chicago Güven, Umay Merve, Yusuf Yakut, Nurdan Çakır, ve Serpil Demirci Kayıran. “Thermosensitive in Situ Gel Formulation and Characterization Studies of Sambucus Ebulus L. Extract”. İstanbul Journal of Pharmacy 53, sy. 1 (Nisan 2023): 30-38.
EndNote Güven UM, Yakut Y, Çakır N, Demirci Kayıran S (01 Nisan 2023) Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract. İstanbul Journal of Pharmacy 53 1 30–38.
IEEE U. M. Güven, Y. Yakut, N. Çakır, ve S. Demirci Kayıran, “Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract”, iujp, c. 53, sy. 1, ss. 30–38, 2023.
ISNAD Güven, Umay Merve vd. “Thermosensitive in Situ Gel Formulation and Characterization Studies of Sambucus Ebulus L. Extract”. İstanbul Journal of Pharmacy 53/1 (Nisan 2023), 30-38.
JAMA Güven UM, Yakut Y, Çakır N, Demirci Kayıran S. Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract. iujp. 2023;53:30–38.
MLA Güven, Umay Merve vd. “Thermosensitive in Situ Gel Formulation and Characterization Studies of Sambucus Ebulus L. Extract”. İstanbul Journal of Pharmacy, c. 53, sy. 1, 2023, ss. 30-38.
Vancouver Güven UM, Yakut Y, Çakır N, Demirci Kayıran S. Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract. iujp. 2023;53(1):30-8.