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Anti-inflammatory activity of a novel lectin isolated from Pleurotus eryngii var. ferulae mushroom

Yıl 2024, Cilt: 54 Sayı: 2, 195 - 204, 26.08.2024

Thoiba Mogahid Hussein Seliman , Gülsüm Altıparmak Ülbegi , Nurten Özsoy , Hevidar Alp Kavlo , Pınar Aksoy Sağırlı

https://doi.org/10.26650/IstanbulJPharm.2024.1322171

Öz

Background and Aims: Pleurotus species are edible mushrooms with important economic and medicinal value. Many phar macological properties of these species, such as anticancer, immunomodulating, and anti-inflammatory activities, have been attributed to lectin. The aim of this study was to purify a novel lectin from Pleurotus eryngii var. ferulae (PEFL) and investigate its anti-inflammatory activity.

Methods:PEFLwaspurifiedby80%ammoniumsulphatefractionation,diethylaminoethyl(DEAE)-Sepharose-4Banionexchange, and Sephadex G-100 gel filtration chromatography. The molar mass of the purified lectin was determined by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) under denaturing conditions. Inhibition of lectin-induced haemagglu tination by several carbohydrates and one glycoprotein (ovalbumin) was also performed using the haemagglutination inhibition activity test. The anti-inflammatory effect of PEFL was tested in a lipopolysaccharide (LPS)-induced inflammation model in mouse macrophage cells (RAW 264.7). The levels of prostaglandin (PG)-E2, tumour necrosis factor-alpha (TNF-𝛼), interleukin 1-beta (IL-1𝛽), interleukin-6 (IL-6), interleukin-10 (IL-10), and interferon-gamma (IFN-𝛾) were determined using enzyme-linked immunosorbent assay (ELISA) kits. Furthermore, the expression of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) was estimated by western blot analysis.

Results: PEFL wasobtained in 16%yield. The specific activity of PEFL was calculated as 1280 haemagglutinating units (HU)/mg protein and was inhibited only by D-galactose. The molecular weight was determined to be 46 kDa. PEFL showed an anti inflammatory effect by reducing the production of pro-inflammatory PGs through COX-2 inhibition, as well as reducing iNOS expression. Furthermore, our findings reported that PEFL has a protective effect on inflammation by decreasing the production of pro-inflammatory cytokines and increasing the production of the anti-inflammatory cytokine (IL-10).

Conclusion:The results suggest that PEFL can be considered as a potential therapeutic agent in the development of new therapeutic strategies for inflammatory diseases.

Anahtar Kelimeler

Cytokines Lectin Lipopolysaccharide Mushroom Pleurotus eryngii var. ferulae RAW 264.7 macrophage

Destekleyen Kurum

Scientific Research Projects Coordination Unit of Istanbul University

Proje Numarası

37626

Kaynakça

  • Akyüz, M. & Kırbağ, S. (2007). Ülkemizde sebze ve meyvelerin yanı sıra alternatif besin kaynağı: yabani mantar (Pleurotus eryngii var. ferulae). Artvin Çoruh Üniversitesi Orman Fakültesi Dergisi 8(1), 26-36. http://ofd.artvin.edu.tr/download/article-file/25715 google scholar
  • Anjana, S.H. & Savita, J.A. (2017). Oyster mushroom: answer to human ailments. Asian Journal of Phar-maceutical and Clinical Research, 10(4), 24-27. https://doi.org/10.22159/ajpcr.2017.v10i4.16867 google scholar
  • Bobek, P., Nosalova, V. & Cerna, S. (2001). Effect of pleuran (beta-glucan from Pleurotus ostreatus) in diet or drinking fluid on colitis in rats. Nahrung, 45(5), 360-363. https://doi.org/10.1002/1521-3803(20011001)45:5<360::AID-FOOD360>3.0.CO;2-C google scholar
  • Choi, D. B., Cha, W. S., Kang, S. H. & Lee, B. R. (2004). Effect of Pleurotus ferulae extracts on viability of human lung cancer and cervical cancer cell lines. Biotechnology and Bioprocess Engi-neering, 9, 356-361. https://doi.org/10.1007/BF02933057 google scholar
  • Choi, J.H., Kim, D.W., Kim, S., & Kim, S.J. (2017). In vitro antioxidant and in vivo hypolipidemic effects of the king oyster culinary-medicinal mushroom, Pleurotus eryngii var. ferulae DDL01 (Agaricomycetes), in rats with high-fat diet-induced fatty liver and hyperlipidemia. Interna-tional Journal of Medicinal Mushrooms, 19(2), 107-119. https://doi.org/10.1615/IntJMedMushrooms.v19.i2.20 google scholar
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  • Dan, X., Liu, W. & Ng, T.B. (2015). Development and applications of lectins as biological tools in biomedi-cal research. Medicinal Research Reviews, 36(2), 221-247. https://doi.org/10.1002/med.21363 google scholar
  • El-Deeb, N.M., El-Adawi, H.I., El-Wahab, A.E.A., Haddad, A.M., El Enshasy, H.A.,He, Y.- W. & Davis, K.R. (2019). Modulation of NKG2D, KIR2DL and cytokine production by Pleurotus os-treatus glucan enhances natural killer cell cytotoxicity toward cancer cells. Frontiers in Cell Developmental Biology, 7, 165. https://doi.org/10.3389/fcell.2019.00165. google scholar
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  • Hassan, M.A.A., Rouf, R., Tiralongo, E., May, T.W. & Tiralongo, J. (2015). Mushroom lectins: Specificity, structure and bioactivity relevant to human disease. International Journal of Molecular Sci-ences, 16(4), 7802-7838. https://doi.org/10.3390/ijms16047802 google scholar
  • Hu, S.H., Lien, J.L., Hsieh, S.L., Wang, J.C. & Chang, S.J. (2009). Antioxidant and antigenotoxicity activities of extracts from liquid submerged culture of culinary-medicinal ferula oyster mushroom, Pleurotus eryngii (DC.) Quel. var. ferulae (Lanzi) Sacc. (Agari-comycetideae). International Journal of Medicinal Mushrooms, 11(4), 395-408. https://doi.org/10.1615/IntJMedMushr.v11.i4.60 google scholar
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  • Jo, K.-J., Ghim, J., Kim, J., Lee, H., Lee, T. G., Kim, J.-I., Kim, Y., Byun, J.W., Min, B.S., Son, J.S., Shim, S.G., Cheon, W.J. & Ryu, S.H. (2019). Water extract of Pleurotus eryngii var. ferulae prevents high-fat diet-induced obesity by inhibiting pancreatic lipase. Journal of Medicinal Food, 22(2), 178-185. https://doi.org/10.1089/jmf.2018.4255 google scholar
  • Jose, N., Ajith, T.A. & Janardhanan, K.K. (2004). Methanol extract of the oyster mushroom, Pleurotus florida, inhibits inflammation and platelet aggregation. Phytotherapy Research, 18(1), 43-46. https://doi.org/10.1002/ptr.1355 google scholar
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  • Laemmli, U.K. (1970). Cleavage of structural proteins during the as-sembly of the head of bacteriophage T4. Nature, 227, 680-685. https://doi.org/10.1038/227680a0 google scholar
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  • Lis, H. & Sharon, N. (1972). Soybean (Glycine max) agglutinin. Meth-ods in Enzymology, 28, 360-365. https://doi.org/10.1016/0076-6879(72)28046-6 google scholar
  • Lull, C., Wichers, H.J. & Savelkoul, H.F.J. (2005). An-tiinflammatory and immunomodulating properties of fun-gal metabolites. Mediators of Inflammation, 2005(2), 63-80. https://doi.org/10.1155/MI.2005.63 google scholar
  • Ma, G., Yang, W., Zhao, L., Pei, F., Fang, D. & Hu, Q. (2018). A critical review on the health promoting effects of mushrooms nutraceuticals. Food Science and Human Wellness, 7, 125-133. https://doi.org/10.1016/j.fshw.2018.05.002 google scholar
  • Minato, K.-i., Laan, L.C., van Die, I. & Mizuno, M. (2019). Pleu-rotus citrinopileatus polysaccharide stimulates anti-inflammatory properties during monocyte-to-macrophage differentiation. Inter-national Journal of Biological Macromolecules, 122, 705-712. https://doi.org/10.1016/j.ijbiomac.2018.10.157. google scholar
  • Mori, K., Kobayashi, C., Tomita, T., Inatomi, S. & Ikeda, M. (2008). Antiatherosclerotic effect of the edible mush-rooms Pleurotus eryngii (Eringi), Grifola frondosa (Maitake), and Hypsizygus marmoreus (Bunashimeji) in apolipopro-tein E-deficient mice. Nutrition Research, 28(5), 335-342. https://doi.org/10.1016/j.nutres.2008.03.010 google scholar
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  • Muszynska, B., Grzywacz-Kisielewska, A., Kala, K. & Gdula-Argasinska, J. (2018). Anti-inflammatory properties of edi-ble mushrooms: A review. Food Chemistry, 243, 373-381. https://doi.org/10.1016/j.foodchem.2017.09.149 google scholar
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Yıl 2024, Cilt: 54 Sayı: 2, 195 - 204, 26.08.2024

Thoiba Mogahid Hussein Seliman , Gülsüm Altıparmak Ülbegi , Nurten Özsoy , Hevidar Alp Kavlo , Pınar Aksoy Sağırlı

https://doi.org/10.26650/IstanbulJPharm.2024.1322171

Öz

Proje Numarası

37626

Kaynakça

  • Akyüz, M. & Kırbağ, S. (2007). Ülkemizde sebze ve meyvelerin yanı sıra alternatif besin kaynağı: yabani mantar (Pleurotus eryngii var. ferulae). Artvin Çoruh Üniversitesi Orman Fakültesi Dergisi 8(1), 26-36. http://ofd.artvin.edu.tr/download/article-file/25715 google scholar
  • Anjana, S.H. & Savita, J.A. (2017). Oyster mushroom: answer to human ailments. Asian Journal of Phar-maceutical and Clinical Research, 10(4), 24-27. https://doi.org/10.22159/ajpcr.2017.v10i4.16867 google scholar
  • Bobek, P., Nosalova, V. & Cerna, S. (2001). Effect of pleuran (beta-glucan from Pleurotus ostreatus) in diet or drinking fluid on colitis in rats. Nahrung, 45(5), 360-363. https://doi.org/10.1002/1521-3803(20011001)45:5<360::AID-FOOD360>3.0.CO;2-C google scholar
  • Choi, D. B., Cha, W. S., Kang, S. H. & Lee, B. R. (2004). Effect of Pleurotus ferulae extracts on viability of human lung cancer and cervical cancer cell lines. Biotechnology and Bioprocess Engi-neering, 9, 356-361. https://doi.org/10.1007/BF02933057 google scholar
  • Choi, J.H., Kim, D.W., Kim, S., & Kim, S.J. (2017). In vitro antioxidant and in vivo hypolipidemic effects of the king oyster culinary-medicinal mushroom, Pleurotus eryngii var. ferulae DDL01 (Agaricomycetes), in rats with high-fat diet-induced fatty liver and hyperlipidemia. Interna-tional Journal of Medicinal Mushrooms, 19(2), 107-119. https://doi.org/10.1615/IntJMedMushrooms.v19.i2.20 google scholar
  • Coelho, L.C.B.B., Silva, P.M.S., Lima, V.L.M., Pontual, E.V., Paiva, P.M.G., Napoleao,T.H. & Correia, M.T.S. (2017). Lectins, interconnecting proteins with biotechnologi-cal/pharmacological and therapeutic applications. Evidence-Based Complementary and Alternative Medicine, 1594074, 1-22. http://dx.doi.org/10.1155/2017/1594074 google scholar
  • Dan, X., Liu, W. & Ng, T.B. (2015). Development and applications of lectins as biological tools in biomedi-cal research. Medicinal Research Reviews, 36(2), 221-247. https://doi.org/10.1002/med.21363 google scholar
  • El-Deeb, N.M., El-Adawi, H.I., El-Wahab, A.E.A., Haddad, A.M., El Enshasy, H.A.,He, Y.- W. & Davis, K.R. (2019). Modulation of NKG2D, KIR2DL and cytokine production by Pleurotus os-treatus glucan enhances natural killer cell cytotoxicity toward cancer cells. Frontiers in Cell Developmental Biology, 7, 165. https://doi.org/10.3389/fcell.2019.00165. google scholar
  • Elhusseiny, S.M., El-Mahdy, T.S., Elleboudy, N.S., Yahia, I.S., Farag, M.M., Ismail, N.S., Yassien, M.A. & Aboshanab, K.M. (2022). In vitro anti SARS-CoV-2 activity and docking analysis of Pleu-rotus ostreatus, Lentinula edodes and Agaricus bisporus edi-ble mushrooms. Infection and Drug Resistance, 15, 3459-3475. https://doi.org/10.2147/IDR.S362823 google scholar
  • Guillot, J. & Konska, G. (1997). Lectins in higher fungi. Biochemical Systematics and Ecology, 25, 203-230.https://doi.org/10.1016/S0305-1978(96)00110-X google scholar
  • Hassan, M.A.A., Rouf, R., Tiralongo, E., May, T.W. & Tiralongo, J. (2015). Mushroom lectins: Specificity, structure and bioactivity relevant to human disease. International Journal of Molecular Sci-ences, 16(4), 7802-7838. https://doi.org/10.3390/ijms16047802 google scholar
  • Hu, S.H., Lien, J.L., Hsieh, S.L., Wang, J.C. & Chang, S.J. (2009). Antioxidant and antigenotoxicity activities of extracts from liquid submerged culture of culinary-medicinal ferula oyster mushroom, Pleurotus eryngii (DC.) Quel. var. ferulae (Lanzi) Sacc. (Agari-comycetideae). International Journal of Medicinal Mushrooms, 11(4), 395-408. https://doi.org/10.1615/IntJMedMushr.v11.i4.60 google scholar
  • Jedinak, A., Dudhgaonkar, S., Wu, Q.L., Simon, J. & Sliva, D. (2011). Anti-inflammatory activity of edible oyster mushroom is mediated through the inhibition of NF-kB and AP-1 signaling. Nutrition Journal, 10, 1-10. https://doi.org/10.1186/1475-2891-10-52 google scholar
  • Jo, K.-J., Ghim, J., Kim, J., Lee, H., Lee, T. G., Kim, J.-I., Kim, Y., Byun, J.W., Min, B.S., Son, J.S., Shim, S.G., Cheon, W.J. & Ryu, S.H. (2019). Water extract of Pleurotus eryngii var. ferulae prevents high-fat diet-induced obesity by inhibiting pancreatic lipase. Journal of Medicinal Food, 22(2), 178-185. https://doi.org/10.1089/jmf.2018.4255 google scholar
  • Jose, N., Ajith, T.A. & Janardhanan, K.K. (2004). Methanol extract of the oyster mushroom, Pleurotus florida, inhibits inflammation and platelet aggregation. Phytotherapy Research, 18(1), 43-46. https://doi.org/10.1002/ptr.1355 google scholar
  • Khan, M.A. & Tania, M. (2012). Nutritional and medicinal importance of Pleurotus mushroom: An overview. Food Reviews International, 28(3), 313-329. https://doi.org/10.1080/87559129.2011.637267 google scholar
  • Laemmli, U.K. (1970). Cleavage of structural proteins during the as-sembly of the head of bacteriophage T4. Nature, 227, 680-685. https://doi.org/10.1038/227680a0 google scholar
  • Li, Y. R., Liu, Q. H., Wang, H. X. & Ng, T. B. (2008). A novel lectin with potent antitumor, mitogenic and HIV-1 reverse transcriptase inhibitory activities from the edible mushroom Pleurotus citrinopileatus. Biochimica et Biophysica Acta (BBA)-General Subjects, 1780(1), 51-57. https://doi.org/10.1016/j.bbagen.2007.09.004 google scholar
  • Lis, H. & Sharon, N. (1972). Soybean (Glycine max) agglutinin. Meth-ods in Enzymology, 28, 360-365. https://doi.org/10.1016/0076-6879(72)28046-6 google scholar
  • Lull, C., Wichers, H.J. & Savelkoul, H.F.J. (2005). An-tiinflammatory and immunomodulating properties of fun-gal metabolites. Mediators of Inflammation, 2005(2), 63-80. https://doi.org/10.1155/MI.2005.63 google scholar
  • Ma, G., Yang, W., Zhao, L., Pei, F., Fang, D. & Hu, Q. (2018). A critical review on the health promoting effects of mushrooms nutraceuticals. Food Science and Human Wellness, 7, 125-133. https://doi.org/10.1016/j.fshw.2018.05.002 google scholar
  • Minato, K.-i., Laan, L.C., van Die, I. & Mizuno, M. (2019). Pleu-rotus citrinopileatus polysaccharide stimulates anti-inflammatory properties during monocyte-to-macrophage differentiation. Inter-national Journal of Biological Macromolecules, 122, 705-712. https://doi.org/10.1016/j.ijbiomac.2018.10.157. google scholar
  • Mori, K., Kobayashi, C., Tomita, T., Inatomi, S. & Ikeda, M. (2008). Antiatherosclerotic effect of the edible mush-rooms Pleurotus eryngii (Eringi), Grifola frondosa (Maitake), and Hypsizygus marmoreus (Bunashimeji) in apolipopro-tein E-deficient mice. Nutrition Research, 28(5), 335-342. https://doi.org/10.1016/j.nutres.2008.03.010 google scholar
  • Motta, F., Gershwin, M.E. & Selmi, C. (2021). Mushrooms and immunity. Journal of Autoimmunity, 117, 102576. https://doi.org/10.1016/j.jaut.2020.102576 google scholar
  • Muramoto, K. (2017). Lectins as bioactive proteins in foods and feeds. Food Science and Technology Research, 23(4), 487-494. https://doi.org/ 10.3136/fstr.23.487 google scholar
  • Muszynska, B., Grzywacz-Kisielewska, A., Kala, K. & Gdula-Argasinska, J. (2018). Anti-inflammatory properties of edi-ble mushrooms: A review. Food Chemistry, 243, 373-381. https://doi.org/10.1016/j.foodchem.2017.09.149 google scholar
  • Ngai, P.H. & Ng, T.B. (2006). A hemolysin from the mushroom Pleu-rotus eryngii. Applied Microbiology and Biotechnology, 72, 11851191. https://doi.org/10.1007/s00253-006-0406-6 google scholar
  • Nozaki, H., Itonori, S., Sugita, M., Nakamura, K., Ohba, K., Suzuki, A. & Kushi, Y. (2008). Mushroom acidic glycosphingolipid induc-tion of cytokine secretion from murine T cells and proliferation of NK1.1 alpha/beta TCR-double positive cells in vitro. Biochem-ical and Biophysical Research Communications, 373, 435-439. https://doi.org/10.1016/j.bbrc.2008.06.047. google scholar
  • Patel, Y., Naraian, R. & Singh, V.K. (2012). Medicinal prop-erties of Pleurotus species (oyster mushroom): A review. World Journal of Fungal and Plant Biology, 3(1), 1-12. https://doi.org/10.5829/idosi.wjfpb.2012.3.1.303 google scholar
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Toplam 47 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık Biyokimyası
Bölüm Original Article
Yazarlar

Thoiba Mogahid Hussein Seliman 0000-0002-9193-1833

Gülsüm Altıparmak Ülbegi 0000-0002-2585-1931

Nurten Özsoy 0000-0002-2419-9128

Hevidar Alp Kavlo 0000-0001-9167-5844

Pınar Aksoy Sağırlı 0000-0002-9432-3163

Proje Numarası 37626
Yayımlanma Tarihi 26 Ağustos 2024
Gönderilme Tarihi 4 Temmuz 2023
Yayımlandığı Sayı Yıl 2024 Cilt: 54 Sayı: 2

Kaynak Göster

APA Mogahid Hussein Seliman, T., Altıparmak Ülbegi, G., Özsoy, N., Alp Kavlo, H., vd. (2024). Anti-inflammatory activity of a novel lectin isolated from Pleurotus eryngii var. ferulae mushroom. İstanbul Journal of Pharmacy, 54(2), 195-204. https://doi.org/10.26650/IstanbulJPharm.2024.1322171
AMA Mogahid Hussein Seliman T, Altıparmak Ülbegi G, Özsoy N, Alp Kavlo H, Aksoy Sağırlı P. Anti-inflammatory activity of a novel lectin isolated from Pleurotus eryngii var. ferulae mushroom. iujp. Ağustos 2024;54(2):195-204. doi:10.26650/IstanbulJPharm.2024.1322171
Chicago Mogahid Hussein Seliman, Thoiba, Gülsüm Altıparmak Ülbegi, Nurten Özsoy, Hevidar Alp Kavlo, ve Pınar Aksoy Sağırlı. “Anti-Inflammatory Activity of a Novel Lectin Isolated from Pleurotus Eryngii Var. Ferulae Mushroom”. İstanbul Journal of Pharmacy 54, sy. 2 (Ağustos 2024): 195-204. https://doi.org/10.26650/IstanbulJPharm.2024.1322171.
EndNote Mogahid Hussein Seliman T, Altıparmak Ülbegi G, Özsoy N, Alp Kavlo H, Aksoy Sağırlı P (01 Ağustos 2024) Anti-inflammatory activity of a novel lectin isolated from Pleurotus eryngii var. ferulae mushroom. İstanbul Journal of Pharmacy 54 2 195–204.
IEEE T. Mogahid Hussein Seliman, G. Altıparmak Ülbegi, N. Özsoy, H. Alp Kavlo, ve P. Aksoy Sağırlı, “Anti-inflammatory activity of a novel lectin isolated from Pleurotus eryngii var. ferulae mushroom”, iujp, c. 54, sy. 2, ss. 195–204, 2024, doi: 10.26650/IstanbulJPharm.2024.1322171.
ISNAD Mogahid Hussein Seliman, Thoiba vd. “Anti-Inflammatory Activity of a Novel Lectin Isolated from Pleurotus Eryngii Var. Ferulae Mushroom”. İstanbul Journal of Pharmacy 54/2 (Ağustos 2024), 195-204. https://doi.org/10.26650/IstanbulJPharm.2024.1322171.
JAMA Mogahid Hussein Seliman T, Altıparmak Ülbegi G, Özsoy N, Alp Kavlo H, Aksoy Sağırlı P. Anti-inflammatory activity of a novel lectin isolated from Pleurotus eryngii var. ferulae mushroom. iujp. 2024;54:195–204.
MLA Mogahid Hussein Seliman, Thoiba vd. “Anti-Inflammatory Activity of a Novel Lectin Isolated from Pleurotus Eryngii Var. Ferulae Mushroom”. İstanbul Journal of Pharmacy, c. 54, sy. 2, 2024, ss. 195-04, doi:10.26650/IstanbulJPharm.2024.1322171.
Vancouver Mogahid Hussein Seliman T, Altıparmak Ülbegi G, Özsoy N, Alp Kavlo H, Aksoy Sağırlı P. Anti-inflammatory activity of a novel lectin isolated from Pleurotus eryngii var. ferulae mushroom. iujp. 2024;54(2):195-204.
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