Determination of Potential Cytotoxic and Mutagenic Effects of Aluminum Acetate

Year 2018, Volume: 12 Issue: 2, 41 - 44, 25.09.2018

Sevim Feyza Erdoğmuş

Abstract

In this study, both cytotoxic and mutagenic effects of aluminum acetate were evaluated by using Allium cepa root meristematic cells and Ames test. In A. cepa test, EC50 value was determined as 156.25 ppm and EC50/2 (78.125ppm), EC50 (156.25 ppm), EC50×2 (312.5 ppm) concentrations of aluminum acetate were used for root growth inhibition and mitotic index (MI) determination tests. A. cepa test results showed that MI significantly decreased with aluminum acetate concentration at each exposure time. Aluminum acetate showed a cytotoxic effect due to decreasing of MI%. It was also observed that aluminum acetate decreased significantly the percentages of prophase, metaphase, anaphase and telophase stages in all concentrations in each exposure time. The aluminum acetate was also investigated for its mutagenic effects at nontoxic concentrations (1000, 500, 250, 125, 62.5 μg/plate) by employing Ames test, as well. These results suggested that aluminum acetate has a weak mutagenic effect at 1000 μg/plate concentration.

Keywords

Allium test, Ames test, cytotoxicity, Aluminum acetate, mutagenicity

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