Antimicrobial Efficacy of Some Products with Propolis Hydroalcoholic Extract 30% and Antiviral Synthesis

Yıl 2018, Cilt: 1 Sayı: 3 - 2nd Propolis Conference Special Issue, 70 - 70, 08.12.2018

Carmen Violeta Popescu Hazem Abbas Stefan Manea Lili Ivopol Alina Dune Candice Popınıuc Dumitru Lupuleasa

Öz

The aim:
The purpose of this
study is to verify and prove antimicrobial efficacy of two topical
pharmaceutical finished products, a gel and a cream, with propolis hydro
alcoholic extract 30% ¹ and an antiviral synthesis used as active
pharmaceuticals ingredients.

These
products are intended especially in the treatment of herpes or any of a group
of viral diseases caused by herpes viruses, affecting the skin (often with
blisters).

Methods
and Materials: The
study of antimicrobial efficacy was performed in accordance with the provisions
of the European Pharmacopoeia, 9th edition, version in force, method described
in Chapter 5.1.3. Efficacy of antimicrobial preservation and acceptance
criteria for preparations for cutaneous use² and the specialty
literature.

The sample
under study was forcedly contaminated with suspensions (10⁵/mL) of Staphylococcus
aureus, Pseudomonas aeruginosa, Candida albicans and Aspergillus
brasiliensis and the times studied were 0, 2, 7, 14, 21, 28 days.

Results:
Acceptance criteria
for antimicrobial efficacy are presented as a logarithmic reduction in the
number of viable microorganisms, calculate the ratio between the number of UFC/
mL from baseline (T₀) and the number of UFC/ mL determined for each
test time and have been fully met.

Conclusions: The
pharmacopoeia requirements were entirely met for the gel product, and the cream
did not prove efficacy on the Candida albicans microorganism.

Anahtar Kelimeler

Antimicrobial Efficacy, Hydroalcoholic Extract, Propolis

Kaynakça

• 1. Abbas H., Popescu V.C., Crisan I., Popa M., Chifiriuc M. C., Gradisteanu Pircalabioru G., Lupuliasa D., Farmacia, 2017, Antibacterial Efficiency of five propolis extract on planktonic and adherent microbial strains, Vol. 65, 5: 813-818, ISSN: 0014-8237 (for the Printed Edition) ISSN: 2065-0019 (for the On-Line Edition).
• 2. European Pharmacopoeia 9th ed. (2017), Strasbourg, FR: European Directorate for the Quality of Medicines.