Comparative Assessment of Silver and Gold Nanoparticles for Dose Enhancement in Layered Skin Geometries: A Monte Carlo Sensitivity Study

Dursun Eşitmez; Mustafa Çağlar; Gülfem Süsoy Doğan

doi:10.28979/jarnas.1862846

Comparative Assessment of Silver and Gold Nanoparticles for Dose Enhancement in Layered Skin Geometries: A Monte Carlo Sensitivity Study

Abstract

This study quantifies nanoparticle-mediated dose modification in an idealized layered skin geometry using Monte Carlo (MCNP 6.3) (skin surface, epidermis ≈100 μm, dermis ≈500 μm, underlying skin). Homogeneous silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) at 5–30 mg/g were embedded in a 1 × 1 × 1 cm³ target, and energy-deposition tallies were converted to absorbed dose and reported as dose-enhancement factors (DEFs) normalized to 0 mg/g. Electron beams (6–12 Mega Electron Volt (MeV)) produced a near-linear DEF–concentration trend in the target with modest superficial gains; in contrast, low-energy photons (50/100 Kilo Electron Volt (keV)) yielded substantially higher enhancement, with AgNPs at 50 keV reaching ~560%, while adjacent normal-tissue sampling regions (OAR1–OAR6) remained near unity with mild, orientation-dependent anisotropy. Skin-layer summaries confirmed surface-weighted increases at low energies and more uniform depth profiles at higher MeV. Statistical uncertainties were <0.05 (1σ). Assumptions included homogeneous nanoparticle uptake and monoenergetic sources; clinical beam spectra and radiobiological endpoints were not evaluated. This work presents energy-specific Monte Carlo sensitivity results to compare relative dose-enhancement trends of AgNP and AuNP in idealized layered skin geometries under controlled monoenergetic beam assumptions.

Keywords

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Details

Primary Language

English

Subjects

Medical Physics

Journal Section

Research Article

Authors

Dursun Eşitmez ^*
0009-0007-4120-0462
Türkiye

Mustafa Çağlar
0000-0002-0106-7683
Türkiye

Gülfem Süsoy Doğan
0000-0002-3760-1999
Türkiye

Publication Date

March 30, 2026

Submission Date

January 13, 2026

Acceptance Date

March 1, 2026

Published in Issue

Year 2026 Volume: 12 Number: 1

DOI

https://doi.org/10.28979/jarnas.1862846

IZ

https://izlik.org/JA76HF78RT

Cite

RIS / Bibtex

APA

Eşitmez, D., Çağlar, M., & Süsoy Doğan, G. (2026). Comparative Assessment of Silver and Gold Nanoparticles for Dose Enhancement in Layered Skin Geometries: A Monte Carlo Sensitivity Study. Journal of Advanced Research in Natural and Applied Sciences, 12(1), 30-44. https://doi.org/10.28979/jarnas.1862846

AMA

1.Eşitmez D, Çağlar M, Süsoy Doğan G. Comparative Assessment of Silver and Gold Nanoparticles for Dose Enhancement in Layered Skin Geometries: A Monte Carlo Sensitivity Study. JARNAS. 2026;12(1):30-44. doi:10.28979/jarnas.1862846

Chicago

Eşitmez, Dursun, Mustafa Çağlar, and Gülfem Süsoy Doğan. 2026. “Comparative Assessment of Silver and Gold Nanoparticles for Dose Enhancement in Layered Skin Geometries: A Monte Carlo Sensitivity Study”. Journal of Advanced Research in Natural and Applied Sciences 12 (1): 30-44. https://doi.org/10.28979/jarnas.1862846.

EndNote

Eşitmez D, Çağlar M, Süsoy Doğan G (March 1, 2026) Comparative Assessment of Silver and Gold Nanoparticles for Dose Enhancement in Layered Skin Geometries: A Monte Carlo Sensitivity Study. Journal of Advanced Research in Natural and Applied Sciences 12 1 30–44.

IEEE

[1]D. Eşitmez, M. Çağlar, and G. Süsoy Doğan, “Comparative Assessment of Silver and Gold Nanoparticles for Dose Enhancement in Layered Skin Geometries: A Monte Carlo Sensitivity Study”, JARNAS, vol. 12, no. 1, pp. 30–44, Mar. 2026, doi: 10.28979/jarnas.1862846.

ISNAD

Eşitmez, Dursun - Çağlar, Mustafa - Süsoy Doğan, Gülfem. “Comparative Assessment of Silver and Gold Nanoparticles for Dose Enhancement in Layered Skin Geometries: A Monte Carlo Sensitivity Study”. Journal of Advanced Research in Natural and Applied Sciences 12/1 (March 1, 2026): 30-44. https://doi.org/10.28979/jarnas.1862846.

JAMA

1.Eşitmez D, Çağlar M, Süsoy Doğan G. Comparative Assessment of Silver and Gold Nanoparticles for Dose Enhancement in Layered Skin Geometries: A Monte Carlo Sensitivity Study. JARNAS. 2026;12:30–44.

MLA

Eşitmez, Dursun, et al. “Comparative Assessment of Silver and Gold Nanoparticles for Dose Enhancement in Layered Skin Geometries: A Monte Carlo Sensitivity Study”. Journal of Advanced Research in Natural and Applied Sciences, vol. 12, no. 1, Mar. 2026, pp. 30-44, doi:10.28979/jarnas.1862846.

Vancouver

1.Dursun Eşitmez, Mustafa Çağlar, Gülfem Süsoy Doğan. Comparative Assessment of Silver and Gold Nanoparticles for Dose Enhancement in Layered Skin Geometries: A Monte Carlo Sensitivity Study. JARNAS. 2026 Mar. 1;12(1):30-44. doi:10.28979/jarnas.1862846

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