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Effect of Atypical Antipsychotic Usage at Therapeutic Doses on Daytime Sleepiness

Year 2023, Volume: 9 Issue: 3, 606 - 614, 20.09.2023
https://doi.org/10.28979/jarnas.1147207

Abstract

The aim of this study is to determine the effect of using atypical antipsychotic drug usage at therapeutic doses on daytime sleepiness. One hundred twenty volunteers who met the inclusion-exclusion criteria were divided into two equal groups. Group 1: patient group (60 patients volunteers used atypical antipsychotic in therapeutic doses and hospitalized in the psychiatry clinic of Tekirdağ Namık Kemal University Hospital and Group 2: control group (60 control volunteers). Socio-demographic and Clinical Information Form consist of 14 questions was administration all volunteers. Also, Epworth Sleepiness Scale which is a survey that determines the degree of sleepiness in eight different situations during the day was administered to all volunteers. Atypical antipsychotic drug usage at therapeutic doses significantly increased patients’ daytime sleepiness compared to the control group. Among the atypical antipsychotic drugs usage in therapeutic dose, the drug that caused the most daytime sleepiness was clozapine. Also, using of atypical antipsychotic drugs in therapeutic doses markedly decreased patients’ life quality compared to the control group. Atypical antipsychotic drug usage at therapeutic doses could cause daytime sleepiness and reduce patients’ quality of life.

References

  • Ahnaou A., Megens A.H.P., Drınkenburg W.H.I.M. (2003). The Atypical Antipsychotics Risperidone, Clozapine and Olanzapine Differ Regarding Their Sedative Potency in Rats Neuropsychobio-logy. 48:47–54
  • Ak A.K., Sarıtaş A.Ş., Gemici Y.İ., Hikmet Yılmaz (2022). Santral Nedenli Hipersomnilere Klinik Yaklaşım ve Ayırıcı Tanı Journal Of Turkish Sleep Medicine. 9:95-114
  • Aker T., Çobanoğlu N., Çobanoğlu Z.S.Ü. 2003. Şizofreni ve Diğer Psikotik Bozukluğu Olan Hasta-larda Tedaviye Uyum Sorunları Düşünen Adam. 16(4): 211-218
  • Beasley CM Jr, Tollefson G, and Tran P. et al. (1996) Olanzapine versus placebo and haloperidol: acute phase results of the North American double-blind olanzapine trial. Neuropsychopharmacology. 14:111–123.
  • Borsini E., Blanco M., Ernst G., Schonfeld S., Salvado A. (2019). Performance of Epworth Sleepiness Scale and Tiredness Symptom Used With Simplified Diagnostic Tests for the Identification of Sleep Apnea Sleep Science. 12(4):287-294
  • Cankorur V.S. (2013). İki Uçlu Bozukluk ve Bilişsel İşlevler Journal of Mood Disorders Volume: 3, Suppl: 1
  • Cohen D., Bonnot O., Bodeau N., Consolı A., Laurent C. (2012). Adverse effects of second-generation antipsychotics in children and adolescents: a Bayesian meta-analysis J Clin Psychop-harmacol. Jun;32(3):309-16
  • Çetin M., Turgay A. (2002). Modern Psikofarmakolojinin Ellinci Yılında Klorpromazinden Günümüze Antipsikotik Tedavinin Dünü, Bugünü Klinik Psikofarmakoloji Bülteni. 12: 211-226
  • Imazu S., Hata T., Toyodo K., Kubo Y., Yamauchı S., Kinoshita S., Nishihara M., Inada K., Kanazawa T. (2021). Safety profile of clozapine: Analysis using national registry data in Japan J Psychiatr Res Sep;141:116-123
  • Karakoç Ö., Akçam T., Gerek M., Birkent H. (2007). Horlama ve Obstüriktif Uyku Apneli Hastalarda Epworth Uykululuk Skalasının Güvenilirliği Elektronik Kulak Burun Boğaz ve Baş Boyun Cer-rahisi Dergisi. Cilt 6, Sayı 3
  • Kendirli M.T., Akgöz G., Özdağ M.F., Tekeli H., Yaşar H., Balıbey H., Kendirli N. (2016). Epworth Uykululuk Testinin Obstrüktif Uyku Apne Sendromu Tanısında Belirleyici Rolü Var mıdır? Gülhane Tıp Dergisi. 58: 161-164 syf
  • Kutlu Y., Polat S. (2019). Ruhsal Bozukluklarda Hastalık Yönetimi ve İyileşme Programı İzmir Kâtip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi. 4(3): 111-115 syf
  • Loebel A.D., Siu C.O., Cucchıaro J.B., Pikalov A.A., Harvey P.D. (2014). Daytime Sleepiness Asso-ciated with Lurasidone and Quetiapine XR: Results from a Randomized Double-Blind, Placebo-Controlled Trial in Patients with Schizophrenia Cns Spectrums. 19(2): 197–205pp
  • Reeve S., Sheaves B. Freeman D. (2021). Excessive Sleepiness in Patients with Psychosis: An Initial Investigation Plos One. 15;16(1)
  • Selvi Y., Kandeğer A., Sayın A.A. (2016). Gündüz Aşırı Uykululuğu Psikiyatride Güncel Yaklaşımlar. 8(2):114-132 syf
  • Sertöz Ö.Ö., Akdeniz F., Vahip s.(2002). Bipolar bozukluk ve şizoaffektif bozukluk sağaltımında kloza-pinin yeri: Geriye dönük bir çalışma Klinik Psikofarmokoloji Bülteni. 12:142-147
  • Sharma S., Kopelovich S.L., Janjua A.U., Pritchett c., Broussard B., Dhır M., Wilson J.G., Goldsmıth D.R., O Cotes R. (2021). Cluster Analysis of Clozapine Consumer Perspectives and Comparison to Consumers on Other Antipsychotics Schizophr Bull Open. 28;2(1)
  • Sürücü E. Özvurmaz S. (2020). Vardiyalı Sistemde Çalışanlarda Gündüz Uykululuğu Halk Sağlığında Güncel Derlemeler. 53-68 syf
  • Weiden P. J. (2007). EPS Profiles: the Atypical Antipsychotics Are Not All the Same Journal of Psyc-hiatric Practise. 13(1):13-24pp
Year 2023, Volume: 9 Issue: 3, 606 - 614, 20.09.2023
https://doi.org/10.28979/jarnas.1147207

Abstract

Thanks

Tekirdağ Namık Kemal Üniversitesi Eğitim ve Araştırma Hastanesi Başhekimliği'ne teşekkürlerimizi sunarız.

References

  • Ahnaou A., Megens A.H.P., Drınkenburg W.H.I.M. (2003). The Atypical Antipsychotics Risperidone, Clozapine and Olanzapine Differ Regarding Their Sedative Potency in Rats Neuropsychobio-logy. 48:47–54
  • Ak A.K., Sarıtaş A.Ş., Gemici Y.İ., Hikmet Yılmaz (2022). Santral Nedenli Hipersomnilere Klinik Yaklaşım ve Ayırıcı Tanı Journal Of Turkish Sleep Medicine. 9:95-114
  • Aker T., Çobanoğlu N., Çobanoğlu Z.S.Ü. 2003. Şizofreni ve Diğer Psikotik Bozukluğu Olan Hasta-larda Tedaviye Uyum Sorunları Düşünen Adam. 16(4): 211-218
  • Beasley CM Jr, Tollefson G, and Tran P. et al. (1996) Olanzapine versus placebo and haloperidol: acute phase results of the North American double-blind olanzapine trial. Neuropsychopharmacology. 14:111–123.
  • Borsini E., Blanco M., Ernst G., Schonfeld S., Salvado A. (2019). Performance of Epworth Sleepiness Scale and Tiredness Symptom Used With Simplified Diagnostic Tests for the Identification of Sleep Apnea Sleep Science. 12(4):287-294
  • Cankorur V.S. (2013). İki Uçlu Bozukluk ve Bilişsel İşlevler Journal of Mood Disorders Volume: 3, Suppl: 1
  • Cohen D., Bonnot O., Bodeau N., Consolı A., Laurent C. (2012). Adverse effects of second-generation antipsychotics in children and adolescents: a Bayesian meta-analysis J Clin Psychop-harmacol. Jun;32(3):309-16
  • Çetin M., Turgay A. (2002). Modern Psikofarmakolojinin Ellinci Yılında Klorpromazinden Günümüze Antipsikotik Tedavinin Dünü, Bugünü Klinik Psikofarmakoloji Bülteni. 12: 211-226
  • Imazu S., Hata T., Toyodo K., Kubo Y., Yamauchı S., Kinoshita S., Nishihara M., Inada K., Kanazawa T. (2021). Safety profile of clozapine: Analysis using national registry data in Japan J Psychiatr Res Sep;141:116-123
  • Karakoç Ö., Akçam T., Gerek M., Birkent H. (2007). Horlama ve Obstüriktif Uyku Apneli Hastalarda Epworth Uykululuk Skalasının Güvenilirliği Elektronik Kulak Burun Boğaz ve Baş Boyun Cer-rahisi Dergisi. Cilt 6, Sayı 3
  • Kendirli M.T., Akgöz G., Özdağ M.F., Tekeli H., Yaşar H., Balıbey H., Kendirli N. (2016). Epworth Uykululuk Testinin Obstrüktif Uyku Apne Sendromu Tanısında Belirleyici Rolü Var mıdır? Gülhane Tıp Dergisi. 58: 161-164 syf
  • Kutlu Y., Polat S. (2019). Ruhsal Bozukluklarda Hastalık Yönetimi ve İyileşme Programı İzmir Kâtip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi. 4(3): 111-115 syf
  • Loebel A.D., Siu C.O., Cucchıaro J.B., Pikalov A.A., Harvey P.D. (2014). Daytime Sleepiness Asso-ciated with Lurasidone and Quetiapine XR: Results from a Randomized Double-Blind, Placebo-Controlled Trial in Patients with Schizophrenia Cns Spectrums. 19(2): 197–205pp
  • Reeve S., Sheaves B. Freeman D. (2021). Excessive Sleepiness in Patients with Psychosis: An Initial Investigation Plos One. 15;16(1)
  • Selvi Y., Kandeğer A., Sayın A.A. (2016). Gündüz Aşırı Uykululuğu Psikiyatride Güncel Yaklaşımlar. 8(2):114-132 syf
  • Sertöz Ö.Ö., Akdeniz F., Vahip s.(2002). Bipolar bozukluk ve şizoaffektif bozukluk sağaltımında kloza-pinin yeri: Geriye dönük bir çalışma Klinik Psikofarmokoloji Bülteni. 12:142-147
  • Sharma S., Kopelovich S.L., Janjua A.U., Pritchett c., Broussard B., Dhır M., Wilson J.G., Goldsmıth D.R., O Cotes R. (2021). Cluster Analysis of Clozapine Consumer Perspectives and Comparison to Consumers on Other Antipsychotics Schizophr Bull Open. 28;2(1)
  • Sürücü E. Özvurmaz S. (2020). Vardiyalı Sistemde Çalışanlarda Gündüz Uykululuğu Halk Sağlığında Güncel Derlemeler. 53-68 syf
  • Weiden P. J. (2007). EPS Profiles: the Atypical Antipsychotics Are Not All the Same Journal of Psyc-hiatric Practise. 13(1):13-24pp
There are 19 citations in total.

Details

Primary Language English
Subjects Biochemistry and Cell Biology (Other)
Journal Section Research Article
Authors

Meltem Alan 0000-0002-3544-0511

Tuğba Nurcan Yüksel 0000-0001-5092-1674

Birol Topcu 0000-0003-0771-2505

Early Pub Date September 19, 2023
Publication Date September 20, 2023
Submission Date July 22, 2022
Published in Issue Year 2023 Volume: 9 Issue: 3

Cite

APA Alan, M., Yüksel, T. N., & Topcu, B. (2023). Effect of Atypical Antipsychotic Usage at Therapeutic Doses on Daytime Sleepiness. Journal of Advanced Research in Natural and Applied Sciences, 9(3), 606-614. https://doi.org/10.28979/jarnas.1147207
AMA Alan M, Yüksel TN, Topcu B. Effect of Atypical Antipsychotic Usage at Therapeutic Doses on Daytime Sleepiness. JARNAS. September 2023;9(3):606-614. doi:10.28979/jarnas.1147207
Chicago Alan, Meltem, Tuğba Nurcan Yüksel, and Birol Topcu. “Effect of Atypical Antipsychotic Usage at Therapeutic Doses on Daytime Sleepiness”. Journal of Advanced Research in Natural and Applied Sciences 9, no. 3 (September 2023): 606-14. https://doi.org/10.28979/jarnas.1147207.
EndNote Alan M, Yüksel TN, Topcu B (September 1, 2023) Effect of Atypical Antipsychotic Usage at Therapeutic Doses on Daytime Sleepiness. Journal of Advanced Research in Natural and Applied Sciences 9 3 606–614.
IEEE M. Alan, T. N. Yüksel, and B. Topcu, “Effect of Atypical Antipsychotic Usage at Therapeutic Doses on Daytime Sleepiness”, JARNAS, vol. 9, no. 3, pp. 606–614, 2023, doi: 10.28979/jarnas.1147207.
ISNAD Alan, Meltem et al. “Effect of Atypical Antipsychotic Usage at Therapeutic Doses on Daytime Sleepiness”. Journal of Advanced Research in Natural and Applied Sciences 9/3 (September 2023), 606-614. https://doi.org/10.28979/jarnas.1147207.
JAMA Alan M, Yüksel TN, Topcu B. Effect of Atypical Antipsychotic Usage at Therapeutic Doses on Daytime Sleepiness. JARNAS. 2023;9:606–614.
MLA Alan, Meltem et al. “Effect of Atypical Antipsychotic Usage at Therapeutic Doses on Daytime Sleepiness”. Journal of Advanced Research in Natural and Applied Sciences, vol. 9, no. 3, 2023, pp. 606-14, doi:10.28979/jarnas.1147207.
Vancouver Alan M, Yüksel TN, Topcu B. Effect of Atypical Antipsychotic Usage at Therapeutic Doses on Daytime Sleepiness. JARNAS. 2023;9(3):606-14.


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