Neuroprotective Effects of Vitamin C and Vitamin E on Oxidative Stress in Rats with Scopolamine-Induced Dementia

Suleiman A. Muhammad; Asma'u D. Aliyu; Abdulsamad O. Abolaji; Amina Jiyah; Ibrahim Bulama; Abdulwasiu Ibrahim; Abdullahi Abbas; Mustapha U. Imam; Lawal Bilbis

doi:10.37212/jcnos.1741523

Neuroprotective Effects of Vitamin C and Vitamin E on Oxidative Stress in Rats with Scopolamine-Induced Dementia

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder that causes cognitive, behavioural, and personality declines. In the etiology of AD, oxidative stress has a main role. This study was carried out to investigate the neuroprotective effects of vitamins C and E on cognitive function and oxidative stress in rats with scopolamine-induced AD. After seven days of treatment with vitamins C and E, AD was induced in the rats on day eight by the injection of 4 mg/kg body weight of scopolamine. Behavioural outcomes such as anxiety, learning and memory were carried out using an elevated plus-maze, and novel object recognition tasks. Malondialdehyde (MDA), antioxidant enzymes, and vitamins were assessed in the brain tissue. Vitamins C and E treatment enhanced memory and behavioural functions in dementia rats when compared with the control group. The results also showed that the vitamin C and vitamin E treated groups had higher brain levels of vitamin C and vitamin E compared to the control group. Furthermore, both treatments reduced the MDA levels compared to the control group. The group that received either of the vitamins indicated higher superoxide dismutase and catalase activities compared to the control group. In conclusion, the results suggest that both vitamins exhibited neuroprotective properties by ameliorating oxidative stress and improving cognitive outcomes in dementia rats.

Keywords

References

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Details

Primary Language

English

Subjects

Cellular Nervous System

Journal Section

Research Article

Authors

Suleiman A. Muhammad ^*
0000-0003-2421-3556
Nigeria

Asma'u D. Aliyu
0009-0006-3888-0690
Nigeria

Abdulsamad O. Abolaji
0009-0005-8880-8139
Nigeria

Amina Jiyah
0009-0009-8370-6060
Nigeria

Ibrahim Bulama
0000-0002-2297-1663
Nigeria

Abdulwasiu Ibrahim
0000-0003-3456-005X
Nigeria

Abdullahi Abbas
0000-0001-7466-721X
Nigeria

Mustapha U. Imam This is me
0000-0001-9888-4809
Nigeria

Lawal Bilbis
0000-0002-6917-4880
Nigeria

Publication Date

October 7, 2025

Submission Date

July 18, 2025

Acceptance Date

September 12, 2025

Published in Issue

Year 2025 Volume: 17 Number: 2

DOI

https://doi.org/10.37212/jcnos.1741523

IZ

https://izlik.org/JA56EN77DX

Cite

RIS / Bibtex

APA

Muhammad, S. A., D. Aliyu, A., Abolaji, A. O., Jiyah, A., Bulama, I., Ibrahim, A., Abbas, A., Imam, M. U., & Bilbis, L. (2025). Neuroprotective Effects of Vitamin C and Vitamin E on Oxidative Stress in Rats with Scopolamine-Induced Dementia. Journal of Cellular Neuroscience and Oxidative Stress, 17(2), 1252-1260. https://doi.org/10.37212/jcnos.1741523

AMA

1.Muhammad SA, D. Aliyu A, Abolaji AO, et al. Neuroprotective Effects of Vitamin C and Vitamin E on Oxidative Stress in Rats with Scopolamine-Induced Dementia. J Cell Neurosci Oxid Stress. 2025;17(2):1252-1260. doi:10.37212/jcnos.1741523

Chicago

Muhammad, Suleiman A., Asma’u D. Aliyu, Abdulsamad O. Abolaji, et al. 2025. “Neuroprotective Effects of Vitamin C and Vitamin E on Oxidative Stress in Rats With Scopolamine-Induced Dementia”. Journal of Cellular Neuroscience and Oxidative Stress 17 (2): 1252-60. https://doi.org/10.37212/jcnos.1741523.

EndNote

Muhammad SA, D. Aliyu A, Abolaji AO, Jiyah A, Bulama I, Ibrahim A, Abbas A, Imam MU, Bilbis L (October 1, 2025) Neuroprotective Effects of Vitamin C and Vitamin E on Oxidative Stress in Rats with Scopolamine-Induced Dementia. Journal of Cellular Neuroscience and Oxidative Stress 17 2 1252–1260.

IEEE

[1]S. A. Muhammad et al., “Neuroprotective Effects of Vitamin C and Vitamin E on Oxidative Stress in Rats with Scopolamine-Induced Dementia”, J Cell Neurosci Oxid Stress, vol. 17, no. 2, pp. 1252–1260, Oct. 2025, doi: 10.37212/jcnos.1741523.

ISNAD

Muhammad, Suleiman A. - D. Aliyu, Asma’u - Abolaji, Abdulsamad O. - Jiyah, Amina - Bulama, Ibrahim - Ibrahim, Abdulwasiu - Abbas, Abdullahi - Imam, Mustapha U. - Bilbis, Lawal. “Neuroprotective Effects of Vitamin C and Vitamin E on Oxidative Stress in Rats With Scopolamine-Induced Dementia”. Journal of Cellular Neuroscience and Oxidative Stress 17/2 (October 1, 2025): 1252-1260. https://doi.org/10.37212/jcnos.1741523.

JAMA

1.Muhammad SA, D. Aliyu A, Abolaji AO, Jiyah A, Bulama I, Ibrahim A, Abbas A, Imam MU, Bilbis L. Neuroprotective Effects of Vitamin C and Vitamin E on Oxidative Stress in Rats with Scopolamine-Induced Dementia. J Cell Neurosci Oxid Stress. 2025;17:1252–1260.

MLA

Muhammad, Suleiman A., et al. “Neuroprotective Effects of Vitamin C and Vitamin E on Oxidative Stress in Rats With Scopolamine-Induced Dementia”. Journal of Cellular Neuroscience and Oxidative Stress, vol. 17, no. 2, Oct. 2025, pp. 1252-60, doi:10.37212/jcnos.1741523.

Vancouver

1.Suleiman A. Muhammad, Asma’u D. Aliyu, Abdulsamad O. Abolaji, Amina Jiyah, Ibrahim Bulama, Abdulwasiu Ibrahim, Abdullahi Abbas, Mustapha U. Imam, Lawal Bilbis. Neuroprotective Effects of Vitamin C and Vitamin E on Oxidative Stress in Rats with Scopolamine-Induced Dementia. J Cell Neurosci Oxid Stress. 2025 Oct. 1;17(2):1252-60. doi:10.37212/jcnos.1741523