Effects of Coenzyme Q10, Ramipril, and Vinpocetine on the Regulation of Oxidative Stress and Cognition in Rats with Chronic Insomnia and REM Sleep Deprivation.

Tanya Sharma; Amberkar Mohanbabu Vittalrao; Meena Kumari K; Divya Thomas; Mohandas Rao K G; Ravindra Maradi

doi:10.37212/jcnos.1822847

Effects of Coenzyme Q10, Ramipril, and Vinpocetine on the Regulation of Oxidative Stress and Cognition in Rats with Chronic Insomnia and REM Sleep Deprivation.

Abstract

This study evaluated the impact of various drugs on cognitive function and oxidative stress in a chronic insomnia rat model induced by rapid eye movement (REM) sleep deprivation using modified multiple-platform method. Forty-eight albino rats were divided into eight groups (n=6 per group): the control group; REM sleep-deprived groups, which were treated with water, corn oil, donepezil, vinpocetine, Coenzyme Q10 + corn oil, ramipril, and Coenzyme Q10 + corn oil + ramipril. Spatial learning and memory were assessed using the Morris water maze. On the 3rd and 4th days of the acquisition trials, the latency of Coenzyme Q10, ramipril and their combination was lower than that of REM sleep-deprived rats. In the probe trial, sleep-deprived rats spent significantly less time in the target quadrant than REM controls . In contrast, vinpocetine, Coenzyme Q10 and the combination of ramipril + Coenzyme Q10 resulted in a significantly greater percentage of time spent in the target quadrant than REM sleep-deprived rats . Biochemical analysis of hippocampal tissue revealed that, compared with REM sleep-deprived rats, those treated with donepezil, vinpocetine, ramipril, Coenzyme Q10, or their combination presented reduced malondialdehyde and acetylcholinesterase levels but increased reduced glutathione levels. In conclusion, these findings suggest that donepezil, vinpocetine, ramipril, Coenzyme Q10, and their combination effectively ameliorate the cognitive deficits and oxidative stress induced by REM sleep deprivation.

Keywords

Supporting Institution

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Ethical Statement

The experiment was conducted after obtaining approval from the Institutional animal ethical committee (Reg. No 94/1999/CPCSEA (IAEC/KMC/130/2019).

Thanks

I thank along with the coauthors for allowing us to resubmit the file.

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Details

Primary Language

English

Subjects

Toxicology, Neurosciences (Other)

Journal Section

Research Article

Authors

Tanya Sharma
0009-0007-3734-6477
India

Amberkar Mohanbabu Vittalrao
0000-0002-3937-2704
India

Meena Kumari K ^*
0000-0002-1506-1442
India

Divya Thomas
0009-0009-0912-6586
India

Mohandas Rao K G
0000-0001-5832-0718
India

Ravindra Maradi
0000-0002-4289-3199
India

Publication Date

April 2, 2026

Submission Date

November 13, 2025

Acceptance Date

March 16, 2026

Published in Issue

Year 2026 Volume: 18 Number: 1

DOI

https://doi.org/10.37212/jcnos.1822847

IZ

https://izlik.org/JA57DU76CB

Cite

RIS / Bibtex

APA

Sharma, T., Vittalrao, A. M., Kumari K, M., Thomas, D., Rao K G, M., & Maradi, R. (2026). Effects of Coenzyme Q10, Ramipril, and Vinpocetine on the Regulation of Oxidative Stress and Cognition in Rats with Chronic Insomnia and REM Sleep Deprivation. Journal of Cellular Neuroscience and Oxidative Stress, 18(1), 1302-1314. https://doi.org/10.37212/jcnos.1822847

AMA

1.Sharma T, Vittalrao AM, Kumari K M, Thomas D, Rao K G M, Maradi R. Effects of Coenzyme Q10, Ramipril, and Vinpocetine on the Regulation of Oxidative Stress and Cognition in Rats with Chronic Insomnia and REM Sleep Deprivation. J Cell Neurosci Oxid Stress. 2026;18(1):1302-1314. doi:10.37212/jcnos.1822847

Chicago

Sharma, Tanya, Amberkar Mohanbabu Vittalrao, Meena Kumari K, Divya Thomas, Mohandas Rao K G, and Ravindra Maradi. 2026. “Effects of Coenzyme Q10, Ramipril, and Vinpocetine on the Regulation of Oxidative Stress and Cognition in Rats With Chronic Insomnia and REM Sleep Deprivation”. Journal of Cellular Neuroscience and Oxidative Stress 18 (1): 1302-14. https://doi.org/10.37212/jcnos.1822847.

EndNote

Sharma T, Vittalrao AM, Kumari K M, Thomas D, Rao K G M, Maradi R (April 1, 2026) Effects of Coenzyme Q10, Ramipril, and Vinpocetine on the Regulation of Oxidative Stress and Cognition in Rats with Chronic Insomnia and REM Sleep Deprivation. Journal of Cellular Neuroscience and Oxidative Stress 18 1 1302–1314.

IEEE

[1]T. Sharma, A. M. Vittalrao, M. Kumari K, D. Thomas, M. Rao K G, and R. Maradi, “Effects of Coenzyme Q10, Ramipril, and Vinpocetine on the Regulation of Oxidative Stress and Cognition in Rats with Chronic Insomnia and REM Sleep Deprivation”., J Cell Neurosci Oxid Stress, vol. 18, no. 1, pp. 1302–1314, Apr. 2026, doi: 10.37212/jcnos.1822847.

ISNAD

Sharma, Tanya - Vittalrao, Amberkar Mohanbabu - Kumari K, Meena - Thomas, Divya - Rao K G, Mohandas - Maradi, Ravindra. “Effects of Coenzyme Q10, Ramipril, and Vinpocetine on the Regulation of Oxidative Stress and Cognition in Rats With Chronic Insomnia and REM Sleep Deprivation”. Journal of Cellular Neuroscience and Oxidative Stress 18/1 (April 1, 2026): 1302-1314. https://doi.org/10.37212/jcnos.1822847.

JAMA

1.Sharma T, Vittalrao AM, Kumari K M, Thomas D, Rao K G M, Maradi R. Effects of Coenzyme Q10, Ramipril, and Vinpocetine on the Regulation of Oxidative Stress and Cognition in Rats with Chronic Insomnia and REM Sleep Deprivation. J Cell Neurosci Oxid Stress. 2026;18:1302–1314.

MLA

Sharma, Tanya, et al. “Effects of Coenzyme Q10, Ramipril, and Vinpocetine on the Regulation of Oxidative Stress and Cognition in Rats With Chronic Insomnia and REM Sleep Deprivation”. Journal of Cellular Neuroscience and Oxidative Stress, vol. 18, no. 1, Apr. 2026, pp. 1302-14, doi:10.37212/jcnos.1822847.

Vancouver

1.Tanya Sharma, Amberkar Mohanbabu Vittalrao, Meena Kumari K, Divya Thomas, Mohandas Rao K G, Ravindra Maradi. Effects of Coenzyme Q10, Ramipril, and Vinpocetine on the Regulation of Oxidative Stress and Cognition in Rats with Chronic Insomnia and REM Sleep Deprivation. J Cell Neurosci Oxid Stress. 2026 Apr. 1;18(1):1302-14. doi:10.37212/jcnos.1822847