Involvement of TRP channels on fibromyalgiainduced pain

Yıl 2018, , 788 - 788, 18.08.2018

Atalay Doğru

https://doi.org/10.37212/jcnos.610116

Öz

Fibromyalgia (FM) is a common chronic pain syndrome affecting up to 2% of the adult population.Several factors such as excessive oxidative stress and overload calcium ion (Ca2+) influx play main roles in the etiology of FM. Several pharmaceutical drugs such as antidepressants and voltage-gated calcium channel blockers are recommended for the treatment of FM; however, they fail to produce a satisfactory response in patients with FM because of the unclear etiology of the disease. Transient receptor potential (TRP) channels have six subfamilies and 27 members in human. Most of these channels are responsible in dorsal root ganglia (DRG) neurons for the Ca2+ permeation especially in neuronal cells. Expression level of the TRPM2 and TRPV1 channels are high in the DRG neurons and they show oxidative stress dependent activation (Tan and McNaughton 2016; Santos et al. 2018). The TRPM2 and TRPV1 channel expression levels in the DRG increased in different types of pain. Selenium as an antioxidant trace element is implicated as a neuroprotective agent in peripheral pain through the inhibition of apoptosis and regulation of the TRPM2 and TRPV1 channels (Kahya et al. 2017). Since a decade, a recent theory have argued that both supporting of intracellular antioxidant system and extracellular antioxidant administration may helpful in fibromyalgia for the inhibition of TRP channels mediated Ca2+ influx (Yüksel et al. 2017). In the oral presentation, I discussed novel effects of selenium on the treatment of irregular oxidative status and fibromyalgia by the regulation of TRPM2 and TRPV1 channels in rats. In conclusion, present literature information indicated that protective effects of selenium on TRPM2 and TRPV1 channels may novel approach to treat FM induced pain and mitochondrial oxidative stress. However, the subject should be clarified by further studies.

Anahtar Kelimeler

Pain, Fibromyalgia, Ca2+ signaling, TRP channels, Selenium

Kaynakça

• Kahya MC, Nazıroğlu M, Övey İS. 2017. Modulation of diabetesinduced oxidative stress, apoptosis, and Ca(2+) entry through TRPM2 and TRPV1 channels in dorsal root ganglion and hippocampus of diabetic rats by melatonin and selenium. Mol Neurobiol. 54:2345-2360.
• Santos FM, Silva JT, Rocha IRC, Martins DO, Chacur M. 2018. Nonpharmacological treatment affects neuropeptide expression in neuropathic pain model. Brain Res. 1687:60-65.
• Tan CH, McNaughton PA. 2016. The TRPM2 ion channel is required for sensitivity to warmth. Nature. 536:460-463.
• Yüksel E, Nazıroğlu M, Şahin M, Çiğ B. 2017. Involvement of TRPM2 and TRPV1 channels on hyperalgesia, apoptosis and oxidative stress in rat fibromyalgia model: Protective role of selenium. Sci Rep. 7:17543.