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Year 2019, Volume: 11 Issue: 1, 797 - 804, 18.06.2019

Yusuf Karagözoğlu , Akif Evren Parlak Naci Ömer Alayunt Semra Türkoğlu İsil Yildirim Mustafa Karatepe

https://doi.org/10.37212/jcnos.579145

Abstract

References

  • Adiguzel R, Esener H, Ergin Z, Aktan E, Turan N, Sekerci M. 2011. Synthesis and Characterization of Novel Ni(II), Cu(II) and Cd(II) Complexes of 4-(2-clorphenylazo)-1hpyrazole-3,5-diamine. Asian J Chem. 23:1846-1850.
  • Amorim E, LC, Brandao SSF, Cavalcanti COM. 1992. Synthesis and structure of substituted bromo and nitrobenzyl benzylidene imidazolidinediones and thiazolidinediones Ann Pharm Fr. 50 (2): 103-111.
  • Ashour MN, Salem SI, El-Gadban HM, Elwan NM, Basu TK. 1999. Antioxidant status in children with protein- energy malnutrition (PEM) living in Cairo, Egypt. Eur J Clin Nutr. 53:669-673.
  • Aydemir B, Kızıler AR, Onaran I, Alici B, Ozkara H, Akyolcu MC. 2006. Impact of Cu and Fe concentrations on oxidative damage in male infertility. Biol Trace Elem Res. 112:193-204.
  • Borras J, Cristea T, Gheorghe A, Scozzafava A, Supuran CT, Tudor V. 1996. Complexes With Biologically Active Ligands. Part 6 Ni(II) Coordination Compounds of Hydrazine and Heterocyclic Sulfonamides as Inhibitors of the Zinc Enzyme Carbonic Anhydrase. Metal Based Drugs. 3:143-148.
  • Brown A and Taylor A. 1985. Applications of aslotted quartz tube and flame atomic absorption spectrophatometry to the analysis of biological samples. Analyst. 110: 579-582.
  • Cesur N, Birteksöz S, Ötük G. 2002. Synthesis and Biological Evaluation of some new thiosemicarbazide, 4-thiazolidinone, 1,3,4-oxadiazole and l,2,4-triazole-3-thione derivatives bearing imidazo[l,2-a]pyridine moiety. Acta PharmTurcica. 44: 23-41.
  • Cheung CCC, Zheng GJ, Li AMY, Richardson BJ, Lam PKS. 2001. Relationship Between Tissue Concentrations of Polycylic Aromatic Hydrocarbons and Antioxidative Responses of Marine Mussels, Perna viridis. Aquat Toxicol. 52(3-4): 189-203.
  • Chan AC, Chow CK, Chiu D. 1999. Interaction of antioxidants and their implication in genetic anemia. Proc Soc Exp Biol Med. 222:274-282.
  • Çetin A, Cansız A, Koparır M, Kazaz C. 2006. The Synthesis And Spectral Investigations Of New Derivatives Of 1,3,4-Oxadiazole, 1,3,4-Thiadiazole, And 1,2,4-Triazole. Organic Chem: An Indian Journal. 2(5-6): 140-149.
  • Das A, Trousdale MD, Ren S, Lien EJ. 1999. Inhibition of Herbes Simplex Virus type 1 and Adeno Virus Type 5 by Heterocyclic SchifF base of Aminohydorxy Guanidine Tosylate. Antiviral Research. 44: 201-208.
  • De Lima, JG, Perrissin M, Chantegrel J, Luu-Duc C, Rousseau A, Narcisse G. 1994. Synthesis and pharmacological evaluation of some 3-phenacyl-5-benzylidene- thiazolidine- 2,4-diones. Arzneim Forch Drug Res. 44 (22): 831-834.
  • Devasagayam TPA, Pushpendran CK, Eapen J. 1983. Differences in lipid peroxidation of rat liver rough and smooth microsomes. Biochim Biophys Acta. 750: 91-97.
  • Diurno MV, Mazzoni O, Piscopo E. 1993. On antimicrobial activity of 3- phenylspiro [ 3H-indole - 3, 2 – thiazolidine] - 2, 4 (1H) – diones. Farmaco. 48 (3): 435-441.
  • Esener H, Adiguzel R, Ergin Z, Aktan E, Turan N, Sekerci M. 2011. Synthesis and Characterization of Novel Mn(II), Co(III), Ni(II) and Cd(II) Complexes from 4-(2-nitrophenylazo)-1H-pryazole-3,5- diamine. Advanced Sci Let. 4:3669-3675.
  • Fioravanti R, Biava M, Donnarumma S, Porretta GC, Simonetti N, Villa A, Porta-Puglia A, Deiddo D, Maullo C, Pompei R. 1996. Synthsesis and microbiological Evaluations of (N- Heteroaryl) Arylmethamines and their their Schif Base. IL Farmoco. 51(10): 643-652.
  • Jackson T, Woo LW, Trusselle MN, Chander SK, Purohit A, Reed MJ, Potter BV. 2007. Dual aromatase- sulfatase inhibitors based on the anastrozole template: synthesis, in vitro SAR, molecular modelling and in vivo activity. Org Biomol Chem. 5(18): 2940- 2952.
  • Kadi AA, El-Brollosy NR, Al-Deeb OA, Habib EE, Ibrahim TM, El-Emam AA. 2007. Synthesis, antimicrobial, and anti-inflammatory activities of novel 2-(1-adamantyl)-5-substituted-1,3,4-oxadiazoles and 2-(1- adamantylamino)-5-substituted-1,3,4-thiadiazoles. European Journal of Medicinal Chemistry. 42 (2): 235- 242.
  • Kritsanida M, Mouroutsou A, Marakos P, Papakonstantinou-Garoufalias S, Pannecouque C, Witvrouw M, De Clercq E. 2002. Antiviral Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1- adamantyl) - 1, 2, 4 – triazolo [3,4-b] [1, 3, 4] thiadiazoles. Il Farmaco. 57 (3): 253-257.
  • Karagozoglu Y, Turkoglu S, Parlak AE, Alayunt NÖ. 2013. The Effects of Hydroxyurea Derivative 1, 3, 4- Thiadiazoles on Serum Biochemical Parameters and Antioxidant Status in Liver of Rats. Digest Journal of Nanomaterials and Biostructures. 8(1): 247 - 253.
  • Karagozoglu Y, Alayunt NO, Karatepe M. 2015. Effects of The Hydroxyurea Derivative 1, 3, 4- Thiadiazoles On Antioxidant Vitamins, MDA in Serums of Rats and Cell Viability of MCF-7 Breast Cancer Cells Journal of Cellular Neuroscience and Oxidative Stress. 7(2): 439-445.
  • Karatepe M, Karatas F. 2006. Antioxidant, Pro-Oxidant Effect of the Thiosemicarbazone Derivative Schiff Base (4-(1– Phenylmethylcyclobutane–3–yl)–2-((2Hydroxybenzylidenehydrazino)Thiazole ) and and its Metal Complexes on Rats. Cell Biochem And Function. 24 (6): 547-554.
  • Larson RA. 1988. The antioxidants of higher plants. Phytochemistry. 27(4): 969-978.
  • Matsumoto T, Ootsu K, and Okada Y. 1974. Effects of 2,2-(Methylenediimino)bis-l,3,4-thiadiazole (NSC- 143019) on Tumor Growth and Immune Responses in Mice. Cancer Chemotherapy Rept. 58: 331-334.
  • Muradian KK, Utko NA, Fraifeld V, Mozzhukhine TG, Pishel IN. 2002. Superoxide dismutase, catalase and glutathione peroxidase activities in the liver of young and old mice: linear regression and correlation. Arch Gerontology Geriatrics. 35: 205-214.
  • Nasr MR, Ali S, Shaker M, Elgabry E. 2002. Antioxidant micronutrients in children with thalassaemia in Egypt. East Mediterr Health J. 8:490-495.
  • Oner H, Karatepe M, Karatas F, Yilmaz I, Cukurovali A. 2005. Effects on the Rat Testes of Thiosemicarbazone Derivative Schiff Base (4-(1-Phenyl- Methylcyclobutane-3-yl)-2-(2- ydroxybenzylidenehydrazino)Thiazole) and its Cadmium (II) Complex. Cell Biochem and Function. 23(6):427-433.
  • Ölçücü A, Çağlar P. 1993. The Zinc Levels in Human Hair and Blood Serum of Infants and Their Relationship to Various Diseases in the Upper Euprates Basin. The Journal of Trace Elements in Experimental Medicine. 6(4): 141-145.
  • Parlak AE, Karagozoglu Y, Alayunt NO, Turkoglu S, Yildirim I, Karatepe M, Koparir M. 2017. Biochemical evaluation of hydroxyurea derivative schiff bases in liver of rats. Cellular and Molecular Biology. 63(10)11:.5-10.
  • Parlak AE, Karagozoglu Y, Alayunt NO, Turkoglu S, Yildirim I, Karatepe M, Koparir M. 2018. The determination of the effect of some 1, 3, 4 - thiadiazole derivatives on biochemical content (Fatty Acids, Sterols, Lypophilic Vitamins) in rat liver. Cellular and Molecular Biology. 64(3)3: 35-39.
  • Reiter RJ, Melchiorri D, Sewerynek E, Poeggeler B, Barlow-Walden L, Chuang J, Ortiz GG, Acuna-Castroviejo D. 1995. A review of the evidence supporting melatonin‘s role as an antioxidant. J Pineal Res. 18(1): 1-11.
  • Sen S, Chakraborty R. 2011. The Role of Antioxidants in Human Health. American Chemical Society, Oxidative Stress: Diagnostics, Prevention and Therapy. ( 1): 1-37.
  • Sinha AK. 1972. Colorimetry assay of catalase. Anal.Biochem. 47: 380.
  • Stewart JA, Ackerly CC, Myers CC, Newman RA, Krakoff IH. 1986. Clinical and clinical pharmacologic studies of 2-amino-1,3,4-thiadiazole. J Cancer Chemother Pharmacol. 16: 287-291.
  • Steinkühler C, Pedersen JZ, Weser U, Rotilio G. 1991. Oxidative stress induced by a di-Schiff base copper complex is both mediated and modulated by glutathione. Biochem Pharmacol. 42:1821-1827.
  • Sur B, Chatterjee SP, Sur P, Maity T, Roychoudhury S. 1990. Studies on the Antiplasticty of Schiff bases Containing 5- Nitrofuran and pyrimidine. Oncology. 47: 433-438.
  • Turan N, Sekerci M. 2009. Synthesis and Characterization of Co (II), Ni (II), Cd (II) and Cu (II) Complexes of Bis-Schiff Bases obtained from 1,8-Diaminonaphthalene. J Chem Soc Pakistan. 31:564-568.
  • Turkoglu S, Karagozoglu Y, Parlak AE, Alayunt NO, Yildirim I. 2014. The Effects of Hydroxyurea Derivative Schiff Bases on Fatty Acids and Lypophilic Vitamins in Liver of Rats. Digest Journal of Nanomaterials and Biostructures. 9(1):159-165.
  • Varvaresou A, Tsantili-Kakoulidou A, Siatra-Papastaikoudi T, Tiligada E. 2000. Synthesis and biological evaluation of indole containing derivatives of thiosemicarbazide and their cyclic 1,2,4-triazole and 1,3,4- thiadiazole analogs. Arzneimittelforschung. 50:48-54.
  • Yang ZY, Yang RD, Li, FS, Yu KB. 2000. Crystal Structure and antitumour Activity of some Rare Earth Metal Complexes with Schiff base. Polyhedron. 19: 2599-2604.
  • Young IS, Woodside JV. 2001. Antioxidants in Health and Disease. J Clin Pathol. 54(3): 176-186.
  • Yoshikawa T, Toyokuni S, Yamamoto Y, Naito Y. 2000. Free radicals in Chemistry, Biology and Medicine. OICA International,London pp 580.

Relationship between some element levels and oxidative stress parameters in rats liver treated with hydroxyurea derivative compounds

Year 2019, Volume: 11 Issue: 1, 797 - 804, 18.06.2019

Yusuf Karagözoğlu , Akif Evren Parlak Naci Ömer Alayunt Semra Türkoğlu İsil Yildirim Mustafa Karatepe

https://doi.org/10.37212/jcnos.579145

Abstract

In this study, effects of hydroxyurea derivatives 1, 3, 4 - thiadiazole and schiff base compounds on some element levels and antioxidant enzyme activities in rat liver and on antioxidant enzyme levels that are parameters of oxidative stress were investigated. For this purpose, iron (Fe), zinc (Zn) and copper (Cu) concentrations were analyzed by using atomic absorption spectroscopy superoxide dismutase (SOD) and catalase (CAT) activities were measured by using a UV spectrophotometer. Fe, Zn and Cu concentrations in the liver of rats treated with these compounds were compared with levels of SOD and CAT statistically. As a result, the increase in the antioxidant activities of SOD and CAT metalloenzymes together with decrease in levels of Cu, Zn and Fe elements observed may suggest that the elements be bound to these enzymes. 

Keywords

Some element oxidative stress rat liver

References

  • Adiguzel R, Esener H, Ergin Z, Aktan E, Turan N, Sekerci M. 2011. Synthesis and Characterization of Novel Ni(II), Cu(II) and Cd(II) Complexes of 4-(2-clorphenylazo)-1hpyrazole-3,5-diamine. Asian J Chem. 23:1846-1850.
  • Amorim E, LC, Brandao SSF, Cavalcanti COM. 1992. Synthesis and structure of substituted bromo and nitrobenzyl benzylidene imidazolidinediones and thiazolidinediones Ann Pharm Fr. 50 (2): 103-111.
  • Ashour MN, Salem SI, El-Gadban HM, Elwan NM, Basu TK. 1999. Antioxidant status in children with protein- energy malnutrition (PEM) living in Cairo, Egypt. Eur J Clin Nutr. 53:669-673.
  • Aydemir B, Kızıler AR, Onaran I, Alici B, Ozkara H, Akyolcu MC. 2006. Impact of Cu and Fe concentrations on oxidative damage in male infertility. Biol Trace Elem Res. 112:193-204.
  • Borras J, Cristea T, Gheorghe A, Scozzafava A, Supuran CT, Tudor V. 1996. Complexes With Biologically Active Ligands. Part 6 Ni(II) Coordination Compounds of Hydrazine and Heterocyclic Sulfonamides as Inhibitors of the Zinc Enzyme Carbonic Anhydrase. Metal Based Drugs. 3:143-148.
  • Brown A and Taylor A. 1985. Applications of aslotted quartz tube and flame atomic absorption spectrophatometry to the analysis of biological samples. Analyst. 110: 579-582.
  • Cesur N, Birteksöz S, Ötük G. 2002. Synthesis and Biological Evaluation of some new thiosemicarbazide, 4-thiazolidinone, 1,3,4-oxadiazole and l,2,4-triazole-3-thione derivatives bearing imidazo[l,2-a]pyridine moiety. Acta PharmTurcica. 44: 23-41.
  • Cheung CCC, Zheng GJ, Li AMY, Richardson BJ, Lam PKS. 2001. Relationship Between Tissue Concentrations of Polycylic Aromatic Hydrocarbons and Antioxidative Responses of Marine Mussels, Perna viridis. Aquat Toxicol. 52(3-4): 189-203.
  • Chan AC, Chow CK, Chiu D. 1999. Interaction of antioxidants and their implication in genetic anemia. Proc Soc Exp Biol Med. 222:274-282.
  • Çetin A, Cansız A, Koparır M, Kazaz C. 2006. The Synthesis And Spectral Investigations Of New Derivatives Of 1,3,4-Oxadiazole, 1,3,4-Thiadiazole, And 1,2,4-Triazole. Organic Chem: An Indian Journal. 2(5-6): 140-149.
  • Das A, Trousdale MD, Ren S, Lien EJ. 1999. Inhibition of Herbes Simplex Virus type 1 and Adeno Virus Type 5 by Heterocyclic SchifF base of Aminohydorxy Guanidine Tosylate. Antiviral Research. 44: 201-208.
  • De Lima, JG, Perrissin M, Chantegrel J, Luu-Duc C, Rousseau A, Narcisse G. 1994. Synthesis and pharmacological evaluation of some 3-phenacyl-5-benzylidene- thiazolidine- 2,4-diones. Arzneim Forch Drug Res. 44 (22): 831-834.
  • Devasagayam TPA, Pushpendran CK, Eapen J. 1983. Differences in lipid peroxidation of rat liver rough and smooth microsomes. Biochim Biophys Acta. 750: 91-97.
  • Diurno MV, Mazzoni O, Piscopo E. 1993. On antimicrobial activity of 3- phenylspiro [ 3H-indole - 3, 2 – thiazolidine] - 2, 4 (1H) – diones. Farmaco. 48 (3): 435-441.
  • Esener H, Adiguzel R, Ergin Z, Aktan E, Turan N, Sekerci M. 2011. Synthesis and Characterization of Novel Mn(II), Co(III), Ni(II) and Cd(II) Complexes from 4-(2-nitrophenylazo)-1H-pryazole-3,5- diamine. Advanced Sci Let. 4:3669-3675.
  • Fioravanti R, Biava M, Donnarumma S, Porretta GC, Simonetti N, Villa A, Porta-Puglia A, Deiddo D, Maullo C, Pompei R. 1996. Synthsesis and microbiological Evaluations of (N- Heteroaryl) Arylmethamines and their their Schif Base. IL Farmoco. 51(10): 643-652.
  • Jackson T, Woo LW, Trusselle MN, Chander SK, Purohit A, Reed MJ, Potter BV. 2007. Dual aromatase- sulfatase inhibitors based on the anastrozole template: synthesis, in vitro SAR, molecular modelling and in vivo activity. Org Biomol Chem. 5(18): 2940- 2952.
  • Kadi AA, El-Brollosy NR, Al-Deeb OA, Habib EE, Ibrahim TM, El-Emam AA. 2007. Synthesis, antimicrobial, and anti-inflammatory activities of novel 2-(1-adamantyl)-5-substituted-1,3,4-oxadiazoles and 2-(1- adamantylamino)-5-substituted-1,3,4-thiadiazoles. European Journal of Medicinal Chemistry. 42 (2): 235- 242.
  • Kritsanida M, Mouroutsou A, Marakos P, Papakonstantinou-Garoufalias S, Pannecouque C, Witvrouw M, De Clercq E. 2002. Antiviral Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1- adamantyl) - 1, 2, 4 – triazolo [3,4-b] [1, 3, 4] thiadiazoles. Il Farmaco. 57 (3): 253-257.
  • Karagozoglu Y, Turkoglu S, Parlak AE, Alayunt NÖ. 2013. The Effects of Hydroxyurea Derivative 1, 3, 4- Thiadiazoles on Serum Biochemical Parameters and Antioxidant Status in Liver of Rats. Digest Journal of Nanomaterials and Biostructures. 8(1): 247 - 253.
  • Karagozoglu Y, Alayunt NO, Karatepe M. 2015. Effects of The Hydroxyurea Derivative 1, 3, 4- Thiadiazoles On Antioxidant Vitamins, MDA in Serums of Rats and Cell Viability of MCF-7 Breast Cancer Cells Journal of Cellular Neuroscience and Oxidative Stress. 7(2): 439-445.
  • Karatepe M, Karatas F. 2006. Antioxidant, Pro-Oxidant Effect of the Thiosemicarbazone Derivative Schiff Base (4-(1– Phenylmethylcyclobutane–3–yl)–2-((2Hydroxybenzylidenehydrazino)Thiazole ) and and its Metal Complexes on Rats. Cell Biochem And Function. 24 (6): 547-554.
  • Larson RA. 1988. The antioxidants of higher plants. Phytochemistry. 27(4): 969-978.
  • Matsumoto T, Ootsu K, and Okada Y. 1974. Effects of 2,2-(Methylenediimino)bis-l,3,4-thiadiazole (NSC- 143019) on Tumor Growth and Immune Responses in Mice. Cancer Chemotherapy Rept. 58: 331-334.
  • Muradian KK, Utko NA, Fraifeld V, Mozzhukhine TG, Pishel IN. 2002. Superoxide dismutase, catalase and glutathione peroxidase activities in the liver of young and old mice: linear regression and correlation. Arch Gerontology Geriatrics. 35: 205-214.
  • Nasr MR, Ali S, Shaker M, Elgabry E. 2002. Antioxidant micronutrients in children with thalassaemia in Egypt. East Mediterr Health J. 8:490-495.
  • Oner H, Karatepe M, Karatas F, Yilmaz I, Cukurovali A. 2005. Effects on the Rat Testes of Thiosemicarbazone Derivative Schiff Base (4-(1-Phenyl- Methylcyclobutane-3-yl)-2-(2- ydroxybenzylidenehydrazino)Thiazole) and its Cadmium (II) Complex. Cell Biochem and Function. 23(6):427-433.
  • Ölçücü A, Çağlar P. 1993. The Zinc Levels in Human Hair and Blood Serum of Infants and Their Relationship to Various Diseases in the Upper Euprates Basin. The Journal of Trace Elements in Experimental Medicine. 6(4): 141-145.
  • Parlak AE, Karagozoglu Y, Alayunt NO, Turkoglu S, Yildirim I, Karatepe M, Koparir M. 2017. Biochemical evaluation of hydroxyurea derivative schiff bases in liver of rats. Cellular and Molecular Biology. 63(10)11:.5-10.
  • Parlak AE, Karagozoglu Y, Alayunt NO, Turkoglu S, Yildirim I, Karatepe M, Koparir M. 2018. The determination of the effect of some 1, 3, 4 - thiadiazole derivatives on biochemical content (Fatty Acids, Sterols, Lypophilic Vitamins) in rat liver. Cellular and Molecular Biology. 64(3)3: 35-39.
  • Reiter RJ, Melchiorri D, Sewerynek E, Poeggeler B, Barlow-Walden L, Chuang J, Ortiz GG, Acuna-Castroviejo D. 1995. A review of the evidence supporting melatonin‘s role as an antioxidant. J Pineal Res. 18(1): 1-11.
  • Sen S, Chakraborty R. 2011. The Role of Antioxidants in Human Health. American Chemical Society, Oxidative Stress: Diagnostics, Prevention and Therapy. ( 1): 1-37.
  • Sinha AK. 1972. Colorimetry assay of catalase. Anal.Biochem. 47: 380.
  • Stewart JA, Ackerly CC, Myers CC, Newman RA, Krakoff IH. 1986. Clinical and clinical pharmacologic studies of 2-amino-1,3,4-thiadiazole. J Cancer Chemother Pharmacol. 16: 287-291.
  • Steinkühler C, Pedersen JZ, Weser U, Rotilio G. 1991. Oxidative stress induced by a di-Schiff base copper complex is both mediated and modulated by glutathione. Biochem Pharmacol. 42:1821-1827.
  • Sur B, Chatterjee SP, Sur P, Maity T, Roychoudhury S. 1990. Studies on the Antiplasticty of Schiff bases Containing 5- Nitrofuran and pyrimidine. Oncology. 47: 433-438.
  • Turan N, Sekerci M. 2009. Synthesis and Characterization of Co (II), Ni (II), Cd (II) and Cu (II) Complexes of Bis-Schiff Bases obtained from 1,8-Diaminonaphthalene. J Chem Soc Pakistan. 31:564-568.
  • Turkoglu S, Karagozoglu Y, Parlak AE, Alayunt NO, Yildirim I. 2014. The Effects of Hydroxyurea Derivative Schiff Bases on Fatty Acids and Lypophilic Vitamins in Liver of Rats. Digest Journal of Nanomaterials and Biostructures. 9(1):159-165.
  • Varvaresou A, Tsantili-Kakoulidou A, Siatra-Papastaikoudi T, Tiligada E. 2000. Synthesis and biological evaluation of indole containing derivatives of thiosemicarbazide and their cyclic 1,2,4-triazole and 1,3,4- thiadiazole analogs. Arzneimittelforschung. 50:48-54.
  • Yang ZY, Yang RD, Li, FS, Yu KB. 2000. Crystal Structure and antitumour Activity of some Rare Earth Metal Complexes with Schiff base. Polyhedron. 19: 2599-2604.
  • Young IS, Woodside JV. 2001. Antioxidants in Health and Disease. J Clin Pathol. 54(3): 176-186.
  • Yoshikawa T, Toyokuni S, Yamamoto Y, Naito Y. 2000. Free radicals in Chemistry, Biology and Medicine. OICA International,London pp 580.
There are 42 citations in total.

Details

Primary Language English
Journal Section Original Articles
Authors

Yusuf Karagözoğlu

Akif Evren Parlak This is me

Naci Ömer Alayunt This is me

Semra Türkoğlu This is me

İsil Yildirim This is me

Mustafa Karatepe

Publication Date June 18, 2019
Published in Issue Year 2019 Volume: 11 Issue: 1

Cite

APA Karagözoğlu, Y., Parlak, A. E., Alayunt, N. Ö., Türkoğlu, S., et al. (2019). Relationship between some element levels and oxidative stress parameters in rats liver treated with hydroxyurea derivative compounds. Journal of Cellular Neuroscience and Oxidative Stress, 11(1), 797-804. https://doi.org/10.37212/jcnos.579145
AMA Karagözoğlu Y, Parlak AE, Alayunt NÖ, Türkoğlu S, Yildirim İ, Karatepe M. Relationship between some element levels and oxidative stress parameters in rats liver treated with hydroxyurea derivative compounds. J Cell Neurosci Oxid Stress. June 2019;11(1):797-804. doi:10.37212/jcnos.579145
Chicago Karagözoğlu, Yusuf, Akif Evren Parlak, Naci Ömer Alayunt, Semra Türkoğlu, İsil Yildirim, and Mustafa Karatepe. “Relationship Between Some Element Levels and Oxidative Stress Parameters in Rats Liver Treated With Hydroxyurea Derivative Compounds”. Journal of Cellular Neuroscience and Oxidative Stress 11, no. 1 (June 2019): 797-804. https://doi.org/10.37212/jcnos.579145.
EndNote Karagözoğlu Y, Parlak AE, Alayunt NÖ, Türkoğlu S, Yildirim İ, Karatepe M (June 1, 2019) Relationship between some element levels and oxidative stress parameters in rats liver treated with hydroxyurea derivative compounds. Journal of Cellular Neuroscience and Oxidative Stress 11 1 797–804.
IEEE Y. Karagözoğlu, A. E. Parlak, N. Ö. Alayunt, S. Türkoğlu, İ. Yildirim, and M. Karatepe, “Relationship between some element levels and oxidative stress parameters in rats liver treated with hydroxyurea derivative compounds”, J Cell Neurosci Oxid Stress, vol. 11, no. 1, pp. 797–804, 2019, doi: 10.37212/jcnos.579145.
ISNAD Karagözoğlu, Yusuf et al. “Relationship Between Some Element Levels and Oxidative Stress Parameters in Rats Liver Treated With Hydroxyurea Derivative Compounds”. Journal of Cellular Neuroscience and Oxidative Stress 11/1 (June 2019), 797-804. https://doi.org/10.37212/jcnos.579145.
JAMA Karagözoğlu Y, Parlak AE, Alayunt NÖ, Türkoğlu S, Yildirim İ, Karatepe M. Relationship between some element levels and oxidative stress parameters in rats liver treated with hydroxyurea derivative compounds. J Cell Neurosci Oxid Stress. 2019;11:797–804.
MLA Karagözoğlu, Yusuf et al. “Relationship Between Some Element Levels and Oxidative Stress Parameters in Rats Liver Treated With Hydroxyurea Derivative Compounds”. Journal of Cellular Neuroscience and Oxidative Stress, vol. 11, no. 1, 2019, pp. 797-04, doi:10.37212/jcnos.579145.
Vancouver Karagözoğlu Y, Parlak AE, Alayunt NÖ, Türkoğlu S, Yildirim İ, Karatepe M. Relationship between some element levels and oxidative stress parameters in rats liver treated with hydroxyurea derivative compounds. J Cell Neurosci Oxid Stress. 2019;11(1):797-804.