Toplantı Özeti
BibTex RIS Kaynak Göster
Yıl 2019, Cilt 11 Supp 1 (BRS), 3 - 3, 21.06.2019
https://doi.org/10.37212/jcnos.584620

Öz

Kaynakça

  • 1: Vandewauw I, De Clercq K, Mulier M, Held K, Pinto S, Van Ranst N, Segal A, Voet T, Vennekens R, Zimmermann K, Vriens J, Voets T. Publisher Correction: A TRP channel trio mediates acute noxious heat sensing. Nature. 2018;559(7713):E7.
  • 2: Mulier M, Vriens J, Voets T. TRP channel pores and local calcium signals. Cell Calcium. 2017;66:19-24.

In vivo and ex vivo imaging of nociceptor expression and activity

Yıl 2019, Cilt 11 Supp 1 (BRS), 3 - 3, 21.06.2019
https://doi.org/10.37212/jcnos.584620

Öz

Our ability to perceive nociceptive pain is crucial to respond to harmful stimuli: it warns us about noxiously hot or cold objects. Sensory nerve endings that respond to pain (nociceptors) initiate an electrical signal in the periphery and transport it to the dorsal horn and eventually to higher brain centers. The detection of noxious stimuli involves the expression of nociceptive ion channels in sensory nerve endings, such as transient receptor potential (TRP) channels. Recently we found that the acute response to noxious heat relies on the functional expression of TRPV1, TRPM3 and TRPA1 in sensory nerve endings. Calcium imaging on isolated dorsal root ganglia (DRG) is a widely accepted model to study the involvement of TRP channels in acute pain responses. However, DRGs are clusters of nerve cell bodies, present in the dorsal root of spinal nerves, far away from the skin where the physiological stimulus detection take place. We use two different optical measurement protocols to study ion channel activity in sensory neurons: an in vivo-protocol to image DRGs and an in tissue-protocol to visualize intact skin measurements. A cre-dependent GCaMP3 mouse line is used. These mice express the genetically encoded calcium indicator GCaMP3 in specific somatosensory neurons. Using this technique, we study the role of TRP channels in different pain models, such as inflammation. 

Kaynakça

  • 1: Vandewauw I, De Clercq K, Mulier M, Held K, Pinto S, Van Ranst N, Segal A, Voet T, Vennekens R, Zimmermann K, Vriens J, Voets T. Publisher Correction: A TRP channel trio mediates acute noxious heat sensing. Nature. 2018;559(7713):E7.
  • 2: Mulier M, Vriens J, Voets T. TRP channel pores and local calcium signals. Cell Calcium. 2017;66:19-24.
Toplam 2 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Tıbbi ve Biyolojik Fizik
Bölüm Original Articles
Yazarlar

Marie Mulıer Bu kişi benim

Joris Vrıens Bu kişi benim

Thomas Voets Bu kişi benim

Yayımlanma Tarihi 21 Haziran 2019
Yayımlandığı Sayı Yıl 2019 Cilt 11 Supp 1 (BRS)

Kaynak Göster

APA Mulıer, M., Vrıens, J., & Voets, T. (2019). In vivo and ex vivo imaging of nociceptor expression and activity. Journal of Cellular Neuroscience and Oxidative Stress, 11, 3-3. https://doi.org/10.37212/jcnos.584620
AMA Mulıer M, Vrıens J, Voets T. In vivo and ex vivo imaging of nociceptor expression and activity. J Cell Neurosci Oxid Stress. Haziran 2019;11:3-3. doi:10.37212/jcnos.584620
Chicago Mulıer, Marie, Joris Vrıens, ve Thomas Voets. “In Vivo and Ex Vivo Imaging of Nociceptor Expression and Activity”. Journal of Cellular Neuroscience and Oxidative Stress 11, Haziran (Haziran 2019): 3-3. https://doi.org/10.37212/jcnos.584620.
EndNote Mulıer M, Vrıens J, Voets T (01 Haziran 2019) In vivo and ex vivo imaging of nociceptor expression and activity. Journal of Cellular Neuroscience and Oxidative Stress 11 3–3.
IEEE M. Mulıer, J. Vrıens, ve T. Voets, “In vivo and ex vivo imaging of nociceptor expression and activity”, J Cell Neurosci Oxid Stress, c. 11, ss. 3–3, 2019, doi: 10.37212/jcnos.584620.
ISNAD Mulıer, Marie vd. “In Vivo and Ex Vivo Imaging of Nociceptor Expression and Activity”. Journal of Cellular Neuroscience and Oxidative Stress 11 (Haziran 2019), 3-3. https://doi.org/10.37212/jcnos.584620.
JAMA Mulıer M, Vrıens J, Voets T. In vivo and ex vivo imaging of nociceptor expression and activity. J Cell Neurosci Oxid Stress. 2019;11:3–3.
MLA Mulıer, Marie vd. “In Vivo and Ex Vivo Imaging of Nociceptor Expression and Activity”. Journal of Cellular Neuroscience and Oxidative Stress, c. 11, 2019, ss. 3-3, doi:10.37212/jcnos.584620.
Vancouver Mulıer M, Vrıens J, Voets T. In vivo and ex vivo imaging of nociceptor expression and activity. J Cell Neurosci Oxid Stress. 2019;11:3-.