The ‘stay-at-home’ order is a kind of mass quarantine strategy and has been enforced globally in response to the COVID-19 pandemic. However, various problems have been reported as well. An electronic research was performed in PubMed and Web of Science databases to determine these problems. This study indicates in a holistic approach to determine some of the potential problems during staying at home mandates. Nutritional disorders, sedentary life, disrupted checkups, eye diseases, increase in alcohol and cigarette consumption, psychological negative influences, sleep disorders, and conflict of generations are among them.