Serum levels of ischemic modified albumin (IMA) and prolidase in migraine subjects

Abstract

Objective: Migraine is one of the most common neurological diseases with headache attacks. Although its pathophysiology is still unclear, it is thought to be multifactorial. Oxidative stress is one of the topics discussed in the pathophysiology of migraine. The aim of this study was to investigate IMA and prolidase levels, which are oxidative stress markers in migraine.

Material and Method: In this study, 35 migraine and 35 healthy controls were included. Serum IMA and prolidase levels were measured in serum obtained after centrifugation from venous blood samples by ELISA. Prolidase and IMA in migraine patients were compared with the control group.

Results: The mean age was 40.06±11.14 years in migraine (34 female, 1 male) and 34.31±8.26 in controls (31 female, 4 male). There was no significant difference between the groups in terms of age and gender (p=0.08, p=0.29). Interictal IMA and prolidase levels of migraine subjects were significantly higher than the control group (p=0.02, p<0.001). Prolidase was significantly higher in the attack period than the control group (p<0.001), but there was no significant difference in IMA levels (p=0.34). Prolidase and IMA levels during the attack were higher than interictal period in migraine but there was no significant difference  (p>0.05).

Conclusion: Prolidase and IMA may be an indicator of oxidative stress in migraine patients. Prolidase, one of the oxidative stress indicators, also correlates with the frequency of attacks in migraine. It is thought that these markers may lead to antioxidant agent studies in prophylactic treatment of migraine.

Keywords

• headache,migraine,IMA,prolidase,interictal

Supporting Institution

Scientific Research Projects Coordination Unit of Kirikkale University

Project Number

2018/052

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