Role of hemogram parameters as predictive markers for propofol injection pain in reproductive and postmenopausal women: a prospective study

Year 2023, Volume: 6 Issue: 5, 1047 - 1051, 28.09.2023

Ömer Taşargöl , Halil Cihan Köse

https://doi.org/10.32322/jhsm.1348328

Abstract

Aims: In clinical practice, propofol injection pain (PIP) is a frequent condition that clinicians could face every day. The aim of this prospective study was to investigate the correlation between PIP and hemogram parameters in reproductive and postmenopausal women.
Methods: In this prospective study, 40 reproductive and 40 postmenopausal female patients who underwent elective surgery were enrolled. Baseline data including age, weight, height, hemogram parameters, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and systemic immune inflammatory score (SII) were recorded preoperatively. The pain was classified as 0: no pain, 1: mild pain, 2: moderate pain, 3: severe pain. Patients were previously informed about the questioning of pain scores during propofol.
Results: The proportion of patients experiencing PIP in postmenopausal (n=16;40%) group was significantly higher than those in the reproductive group (n=6;15%) (p=0.009). When reproductive and postmenopausal groups were compared according to the presence or absence of pain, no difference was found between the groups in terms of hemogram ratios and platelet indices (p>0.05). The NLR, PLR and SII ratios were not significant in predicting the presence of PIP.
Conclusion: The findings of our study showed that the occurrence of PIP in postmenopausal women was higher compared to women in reproductive age. Hemogram values, NLR platelet, PLR and SII ratios were not significantly associated with the presence of PIP.

Keywords

Propofol, pain, neutrophil, hemogram, postmenopausal

References

• Wakai A, Blackburn C, McCabe A, et al. The use of propofol for procedural sedation in emergency departments. Cochrane Database Syst Rev. 2015;2015(7):CD007399.
• Zhi Y, Li W. Effects of total intravenous anesthesia with etomidate and propofol on postoperative cognitive dysfunction. Physiol Res. 2023;72(2):251-258.
• Desousa KA. Pain on propofol injection: causes and remedies. Indian J Pharmacol. 2016;48(6):617-623.
• Nishimoto R, Kashio M, Tominaga M. Propofol-induced pain sensation involves multiple mchanisms in sensory neurons. Pflugers Arch. 2015;467(9):2011-2020.
• Lang BC, Yang CS, Zhang LL, Zhang WS, Fu YZ. Efficacy of lidocaine on preventing incidence and severity of pain associated with propofol using in pediatric patients: A PRISMA-compliant meta-analysis of randomized controlled trials. Medicine. 2017;96(11):e6320.
• Ayatollahi V, Behdad S, Kargar S, Yavari T. Comparison of effects of ephedrine, lidocaine and ketamine with placebo on injection pain, hypotension and bradycardia due to propofol injection: a randomized placebo controlled clinical trial. Acta Med Iran. 2012;50(9):609.
• Gilani MT, Bameshki A, Razavi M. Efficacy of ephedrine in the prevention of vascular pain associated with different infusion rates of propofol. Anesth Essays Res. 2014;8(3):345-348.
• Zahedi H, Maleki A, Rostami G. Ondansetron pretreatment reduces pain on injection of propofol. Acta Med Iran. 2012;50(4):239-243.
• Tasargol O. A Prospective study on the predictability of propofol injection pain. Cureus. 2020;12(2):e6945.
• Miniksar OH, Yuksek A. Effects of preoperative anxiety levels and the D-type personality on propolol injection pain. North Clin Istanb. 2022;9(1):1-7.
• McCrirrick A, Hunter S. Pain on injection of propofol: the effect of injectate temperature. Anaesthesia. 1990;45:443-444.
• Daoudia M, Decruynaere C, Le Polain de Waroux B, Thonnard JL, Plaghki L, Forget P. Biological inflammatory markers mediate the effect of preoperative pain-related behaviours on postoperative analgesics requirements. BMC Anesthesiol. 2015;15:183.
• Hanci V, Ayoğlu H, Yilmaz M, et al. Effect of menstrual cycle on the injection pain due to propofol. Eur J Anaesthesiol. 201;27(5):425-427.
• Facchinetti F, Borella P, Valentini M, Fioroni L, Genazzani AR. Premenstrual increase of intracellular magnesium levels in women with ovulatory, asymptomatic menstrual cycles. Gynecol Endocrinol. 1988;2(3):249-256.
• Chen Y, Zhang Y, Zhao G, et al. Difference in leukocyte composition between women before and after menopausal age, and distinct sexual dimorphism. PLoS One. 2016;11(9):e0162953.
• Canikli Adıgüzel Ş, Akyurt D, Bahadır Altun H, Tulgar S, Ültan Özgen G. Can neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, or systemic immune inflammation index be an indicator of postoperative pain in patients undergoing laparoscopic cholecystectomy? Cureus. 2023;15(1):e33955.
• Canbolat N, Buget MI, Sivrikoz N, Altun D, Kucukay S. [The relationship between neutrophil to lymphocyte ratio and postoperative pain in total knee and hip arthroplasty]. Braz J Anesthesiol. 2019;69(1):42-47.
• Yigit Y, Yilmaz S, Ozbek AE, Karakayali O, Cetin B, Halhalli HC. Can platelet indices reduce negative appendectomy rates? Cureus. 2019;11(3):e4293.
• Furuncuoğlu Y, Tulgar S, Dogan AN, Cakar S, Tulgar YK, Cakiroglu B. How obesity affects the neutrophil/lymphocyte and platelet/lymphocyte ratio, systemic immune-inflammatory index and platelet indices: a retrospective study. Eur Rev Med Pharmacol Sci. 2016;20(7):1300-1306.
• Tulgar YK, Cakar S, Tulgar S, Dalkilic O, Cakiroglu B, Uyanik BS. The effect of smoking on neutrophil/lymphocyte and platelet/lymphocyte ratio and platelet indices: a retrospective study. Eur Rev Med Pharmacol Sci. 2016;20(14):3112-3118.
• Islamoglu E, Tas S, Karamik K, Yalcinkaya S, Tokgoz H, Savas M. Does extracorporeal shock wave lithotripsy-related pain get affected by menstrual cycle and menopause? Urolithiasis. 2019;47(6):575-581.
• Frange C, Hirotsu C, Hachul H, et al. Musculoskeletal pain and the reproductive life stage in women: is there a relationship? Climacteric. 2016;19(3):279-284.