Epidemiology of Nocardiosis -A six years study from Northern India

Yıl 2016, Cilt: 6 Sayı: 2 - J Microbiol Infect Dis 2016; 06(02) June Issue, 60 - 64, 01.06.2016

Reetika Dawar Ruchi Girotra

https://doi.org/10.5799/jmid.328801

Cited By: 1

Öz

Objective: To isolate and speciate Nocardia species from clinical samples and to study their antimicrobial susceptibility
pattern to different antimicrobials. Various risk factors associated with nocardiosis were also studied.
Methods: 32 clinical specimens with clinical history of pneumonia, abscesses, or disseminated infections were collected
over a period of 6 years (2009-2014) from Inpatient and Outpatient departments and processed for Nocardia cultures
and sensitivity.
Results: Twelve cases of nocardiosis were reported out of 32 clinically suspected cases. The mean age of presentation
in our study was 57.9 years. Pneumonia was the most common clinical presentation followed by primary cutaneous
disease and one case of disseminated disease. 8/ 10 patients with nocardiosis were immunocompromised with history
of organ transplantation, use of immunosuppressive agents or steroids. Based on biochemical reactions 5 of the isolates
were identified as N. asteroides, 3 N. brasiliensis, 2 N. farcinica and 1 each were N. transvalensis, & N. nova. All were
sensitive to linezolid followed by cotrimoxazole (91.6%)
Conclusions: With increasing number of immunocompromised patients and an increased incidence of nocardiosis,
diagnosis of Nocardia infections should always be kept in mind as it can present with nonspecific symptoms and can
mimic confused with other diseases. Linezolid, Cotrimoxazole, imipenem and minocycline were found to be very effective,
in vitro, against most Nocardia species. J Microbiol Infect Dis 2016;6(2): 60-64    

Anahtar Kelimeler

Nocardiosis, pulmonary, Incidence, India, resistance, immunocompromised, bacterial infections

Kaynakça

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