SYNTHESIS AND CHARACTERIZATION OF SOME NEW HYDRAZONES WITH ANTI‐UREASE ACTIVITIES

Yıl 2018, Cilt: 3 Sayı: 2, 71 - 74, 01.06.2018

Yusuf Sıcak

https://doi.org/10.5281/zenodo.2553565

Öz

Hydrazones were considered as signiŞcant substrates in drug discovery process. Therefore, a seriesof some new 1- 4- 1- 2- 4-substitutedphenyl hydrazono ethyl phenyl -3- 4-nitrophenyl ureaderivatives were synthesized as potential urease inhibitory agents. The synthesizedcompounds were characterized by FTIR, ¹H NMR, 13C NMR, and elemental analysis C, H, N . Allcompounds were evaluated in vitro for urease inhibitory potential. Among synthesized compounds,8, 7, 6, and 4 showed excellent activities IC50 i.e. 10.13±0.40, 12.15±0.22, 17.81±0.36, and22.95±0.47 µM, respectively. This study has culminated in the identiŞcation of some compoundswhich can serve as leads for new potent urease inhibitors

Anahtar Kelimeler

organic synthesis, Urease inhibition activity, Hydrazone, Enzyme inhibitors, Urea

Kaynakça

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