CRISPR-Cas9 Teknolojisi ile Genetik Hastalıkların Tedavisi: Yeni Bir Devrim

Year 2025, Volume: 03, 29 - 40, 26.03.2025

Sebile Azırak , Ahmet Genç

https://doi.org/10.54709/joebs.1641221

https://izlik.org/JA98CU83KK

Abstract

Günümüzde, genetik hastalıkların artması sonucu tedavide yaşanan zorluklar bilim insanlarını yeni tedavi arayışlarına yöneltmiştir. Bu konuda en önemli bilimsel gelişmelerden biri düzenli aralıklarla kümelenmiş kısa palindromik tekrarlarla (CRISPR)/CRISPR ilişkili enzim (Cas) tabanlı genom düzenleme teknolojisinin uygulanmaya başlaması sonucu birçok genetik hastalığın tedavi edilmesinde umut vadeden araçlardan biri haline gelmiştir. CRISPR/Cas daha önce bakterilerde ve arkelerde viral enfeksiyonlara karşı adaptif bağışıklık savunma sisteminden uyarlanmış bir genom düzenleme aracı olarak bilinmekteydi. Bu incelemede CRISPR-Cas9 teknolojisinin kökenini, bugünü ve geleceğini, uygulama alanlarını, genetik hastalıkların tedavisindeki yeri ve önemini, zorluklarını, sınırlıklarını ve bu teknolojinin kullanımı ile ilgili etik kaygıları tartışıyoruz.

Keywords

CRISPR , Gen Düzenlenmesi , Genetik Hastalıklar

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