Diyabetik Kardiyomiyopati ve Moleküler Temeli: Derleme.

Yıl 2015, Cilt: 1 Sayı: 2, 37 - 41, 20.06.2015

Derya Güzel

Öz

Diabetes is a problem of public health that increases due to changes of life and eating habits. One of the most important complications of this disease is cardiomyopathy. Reasons that bring out diabetic cardiomyopathy include hyperglycemia, reaktive oksigen species (ROS), activation of DAG/PKC (diachyl glicerol/protein kinase C) pathway, upregulation of reninangiotensin-aldosteron system, fail of response to hypoxia , endothelial disfunction and otonomic neuropathy. This review aims to develop new treatment steps analyzing the pathophysiology of diabetic cardiomyopathy

Anahtar Kelimeler

Diabetic cardiomyopathy, DAG / PKC, reactive oxygen species

Diyabetik Kardiyomiyopati ve Moleküler Temeli: Derleme

Öz

Diyabet sedanter yaşam ve beslenme alışkanlıklarının değişimi sonucu insidansı artan bir toplum sağlığı problemdir. Bu hastalığın en önemli komplikasyonlarından biri diyabetik kardiyomyopatidir. Diyabetik kardiyomyopatinin meydana gelmesinde hiperglisemi, reaktif oksijen türevleri (ROS), DAG/PKC (diaçil gliserol/protein kinaz C) sinyal yolağının aktivasyonu, renin-anjiyotensin-aldosteron sisteminin upregülasyonu, hipoksiye yanıtın bozulması, endotel disfonksiyonu ve otonomik nöropati gibi birçok sebep yer almaktadır. Bu derleme ile diyabetik kardiyomyopatinin patoŞ zyolojisine ışık tutarak yeni tedavi basamakları geliştirilebilmesi amaçlanmaktadır

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