Öz
Marginal zone lymphomas (MZL) represent a group of low grade lymphomas whose cells originate from B lymphocytes normally present in marginal zone of the secondary lymphoid follicles. According to World Healt Organization (WHO) classifi cation, MZL is described with three subtypes: extranodal MALT lymphoma, splenic MZL and nodal MZL. All threemarginal zone cell lymphomass hareimmuno-phenotypic, genetic and chromosomal similarities. Extranodal MALT lymphoma is an indolent disease that presents within volvement of mucosa associated lenfoid tissue (MALT) by a long-persistent local-ized mass with less frequent bone marrow and peripheral lymphnode involvement. We would like to report a 84 year old woman with splenic marginal zone lymphoma who presented with weak ness and fatigue
Anahtar Kelimeler
Splenic Marginal Zone Lymphoma peripheral smear bone marrow fl owcy tometry
Kaynakça
- Joshi M, Sheikh H, Abbi K, Long S, Sharma K, Tulchinsky M, Epner E.
- Marginalzonelymphoma: old, new, targeted, andepigenetictherapies.
- TherAdvHematol2012;3:275-290.
- ZinzaniPL. Themanyfaces of marginalzonelymphoma.
- HematologyAmSocHematolEduc Program 2012;2012:426-432.
- Arcaini L, Paulli M, Boveri E, Magrini U, Lazzarino M. Marginalzone-related
- neoplasms of splenicandnodalorigin. Haematologica 2003;88:80-93.
- Iannitto E, Ambrosetti A, Ammatuna E, Colosio M, Florena AM, Tripodo
- C, et al. Splenicmarginalzonelymphomawithorwithoutvillouslymphocyt
- es. Hematologic indingsandoutcomes in a series of 57 patients. Cancer
- ;101:2050-2057.
- Parry-Jones N, Matutes E, Gruszka-Westwood AM, SwansburyGJ,
- WotherspoonAC, Catovsky D. Prognosticfeatures of spleniclymphomawith
- villouslymphocytes: a report on 129 patients. Br J Haematol 2003;120:759-
- -
- Franco V, Florena AM, Iannitto E. Splenicmarginalzonelymphoma. Blood
- ;101:2464-2472.
- Thieblemont C, Felman P, Berger F, Dumontet C, Arnaud P, Hequet O, et
- al. Treatment of splenicmarginalzone B-celllymphoma: an analysis of 81
- patients. ClinLymphoma 2002;3:41-47.
- Salido M, Baro C, Oscier D, Stamatopoulos K, Dierlamm J, Matutes E, et
- al. Cytogenetic aberrationsandtheirprognosticvalue in a series of 330
- splenicmarginalzone B-celllymphomas: a multicenterstudy of theSplenic
- B-Cell LymphomaGroup. Blood 2010;116:1479-1488.
- Boveri E, Arcaini L, Merli M, Passamonti F, Rizzi S, Vanelli L, et al. Bone
- marrow histology in marginalzone B-celllymphomas: correlationwithclinic
- alparameters andflowcytometry in 120 patients. AnnOncol 2009;20:129-
- -
- Berger F, Felman P, Thieblemont C, Pradier T, Baseggio L, BryonPA,
- et al. Non- MALT marginalzone B-celllymphomas: a description of
- clinicalpresentationand outcome in 124 patients. Blood 2000;95:1950-
- -
- Kaynaklar
Öz
Marjinal zonlenfomalar(MZL) sekonderlenfoidfolliküllerinmarjinalzonunda bulunan B lenfositlerden köken alan düşük dereceli lenfomalardır. Dünya Sağlık Örgütü (WHO)'nün sınıfl andırmasına göre marjinalzonlenfomalar, ekstranodal MALT lenfoma, splenikMZL ve nodalMZL olmak üzere 3 alt gruba ayrılır. Her 3 grubun kromozomal, genetik ve immünfenotipik yönden benzerlikleri vardır. Ekstranodal MALT lenfomalar kemik iliği ve periferik lenf nodu tutuluşunun çok nadir görüldüğü, uzun süre lokalize bir kitle olarak kalan, mukoza ile ilişkili lenfoid dokuyu (MALT) tutan yavaş seyirli lenfomalardır. Biz burada halsizlik, yorgunluk şikayeti ile başvuran ve marjinalzonlenfoma tanısı konan 84 yaşındaki bayan olgu sunmayı amaçladık
Anahtar Kelimeler
Splenik Marginal Zone Lenfoma periferik yayma kemik iliği akım sitometrisi
Kaynakça
- Joshi M, Sheikh H, Abbi K, Long S, Sharma K, Tulchinsky M, Epner E.
- Marginalzonelymphoma: old, new, targeted, andepigenetictherapies.
- TherAdvHematol2012;3:275-290.
- ZinzaniPL. Themanyfaces of marginalzonelymphoma.
- HematologyAmSocHematolEduc Program 2012;2012:426-432.
- Arcaini L, Paulli M, Boveri E, Magrini U, Lazzarino M. Marginalzone-related
- neoplasms of splenicandnodalorigin. Haematologica 2003;88:80-93.
- Iannitto E, Ambrosetti A, Ammatuna E, Colosio M, Florena AM, Tripodo
- C, et al. Splenicmarginalzonelymphomawithorwithoutvillouslymphocyt
- es. Hematologic indingsandoutcomes in a series of 57 patients. Cancer
- ;101:2050-2057.
- Parry-Jones N, Matutes E, Gruszka-Westwood AM, SwansburyGJ,
- WotherspoonAC, Catovsky D. Prognosticfeatures of spleniclymphomawith
- villouslymphocytes: a report on 129 patients. Br J Haematol 2003;120:759-
- -
- Franco V, Florena AM, Iannitto E. Splenicmarginalzonelymphoma. Blood
- ;101:2464-2472.
- Thieblemont C, Felman P, Berger F, Dumontet C, Arnaud P, Hequet O, et
- al. Treatment of splenicmarginalzone B-celllymphoma: an analysis of 81
- patients. ClinLymphoma 2002;3:41-47.
- Salido M, Baro C, Oscier D, Stamatopoulos K, Dierlamm J, Matutes E, et
- al. Cytogenetic aberrationsandtheirprognosticvalue in a series of 330
- splenicmarginalzone B-celllymphomas: a multicenterstudy of theSplenic
- B-Cell LymphomaGroup. Blood 2010;116:1479-1488.
- Boveri E, Arcaini L, Merli M, Passamonti F, Rizzi S, Vanelli L, et al. Bone
- marrow histology in marginalzone B-celllymphomas: correlationwithclinic
- alparameters andflowcytometry in 120 patients. AnnOncol 2009;20:129-
- -
- Berger F, Felman P, Thieblemont C, Pradier T, Baseggio L, BryonPA,
- et al. Non- MALT marginalzone B-celllymphomas: a description of
- clinicalpresentationand outcome in 124 patients. Blood 2000;95:1950-
- -
- Kaynaklar
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 18 Aralık 2015 |
| Gönderilme Tarihi | 18 Aralık 2015 |
| Yayımlandığı Sayı | Yıl 2015 Cilt: 1 Sayı: 3 |