The relationship between anti mullerian hormone level and endometrial polyp frequency in patients with polycystic ovary syndrome

Yıl 2022, , 263 - 267, 26.09.2022

Asena Ayar Madenli , İnci Öz , Tuğba Gürbüz

https://doi.org/10.47582/jompac.1148111

Cited By: 1

Öz

Aim: This study aimed to conduct a case-control study to determine the relationship between serum anti mullerian hormone (AMH) levels and frequency of endometrial polyp in women with polycystic ovary syndrome (PCOS).
Material and Method: Patients with endometrial polyps (n=55) were included in the study group. The control group was selected from women without endometrial polyps (n=49). The relationship between the case and control groups was studied using the chi-square test to check the AMH levels and endometrial polyps.
Results: The participants’ age and body mass index (BMI) were 28.20±3.08 and 25.45±2.25, respectively. There was a statistically significant association between AMH levels and endometrial polyp (p-value <0.001). There was no significant difference between the endometrial polyps group and the control group in terms of age, BMI, prolactin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulphate (DHEA-SO4), total testosterone, estradiol, thyroid-stimulating hormone (TSH) and thyroxine (T4) (p-value >0.05).
Conclusion: This research showed that the frequency of endometrial polyps increases with higher AMH levels in PCOS patients.

Anahtar Kelimeler

Anti mullerian hormone, endometrial polyp, polycystic ovary syndrome

Polikistik over sendromlu hastalarda anti müllerian hormon düzeyi ile endometrial polip sıklığı arasındaki ilişki

Öz

Amaç: Bu çalışmada polikistik over sendromlu (PKOS) kadınlarda serum anti mullerian hormon (AMH) düzeyleri ile endometrial polip sıklığı arasındaki ilişkiyi belirlemeyi amaçladık.
Gereç ve Yöntem: Çalışma grubuna endometrial polipli hastalar (n=55) dahil edildi. Kontrol grubu endometrial polip olmayan kadınlardan (n=49) seçildi. Olgu ve kontrol grupları arasındaki ilişki, AMH düzeylerini ve endometriyal polipleri kontrol etmek için ki-kare testi kullanılarak araştırıldı.
Bulgular: Katılımcıların yaş ve vücut kitle indeksi (VKİ) sırasıyla 28,20±3,08 ve 25,45±2,25 idi. AMH seviyeleri ile endometrial polip arasında istatistiksel olarak anlamlı bir ilişki saptandı (p değeri <0,001). Endometriyal polip grubu ile kontrol grubu arasında yaş, VKI, prolaktin, folikül uyarıcı hormon (FSH), luteinize edici hormon (LH), dehidroepiandrosteron sülfat (DHEA-SO4), total testosteron, östradiol, tiroid uyarıcı hormon (TSH) ve tiroksin (T4) değerleri açısından anlamlı farklılık saptanmadı (p değeri >0,05).
Sonuç: Bu araştırma, PKOS hastalarında yüksek AMH seviyeleri ile endometrial polip sıklığının arttığını göstermiştir.

Anahtar Kelimeler

Anti müllerian hormone, endometrial polip, polikistik over sendromu

Kaynakça

• Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yildiz BO. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab 2004; 89: 2745-9.
• Gürbüz T , Gungor ND, Yurci A. Does intracytoplasmic sperm injection increase the risk of gestational diabetes in patients with polycystic over? Anatolian Curr Med J 2021; 3: 53-8.
• Gungor ND, Gurbuz T. Pregnancy outcomes of intrauterine insemination in age-matched young women according to serum anti-mullerian hormone levels. JRM 2021; 66: 195-202.
• Güngör ND, Gürbüz T. Prediction of the number of oocytes based on AMH and FSH levels in IVF candidates. J Surg Med 2020; 4: 733-7.
• Gurbuz T, Gungor ND, Okcu NT, and Tosun SA. “correlation between anti-mullerian hormone levels and sexual dysfunction in infertile women”. ARJGO 2020; 4: 10-6.
• Gungor ND, Gurbuz T, Onal M. Comparison of complication rates after transvaginal ultrasound-guided oocyte pick-up procedures with respect to ovarian response. Clin Exp Reprod Med 2022; 49: 142-8.
• Yurci A, Gungor ND. Low antimullerian hormone levels improve fertility outcome in patients with polycystic ovary syndrome. Gynecol Reprod Health 2021; 5: 1-5.
• Silberstein T, Saphier O, van Voorhis BJ, Plosker SM. Endometrial polyps in reproductive-age fertile and infertile women. Isr Med Assoc J 2006; 8: 192-5.
• Vander Borght M, Wyns C. Fertility and infertility: Definition and epidemiology. Clin Biochem 2018; 62: 2-10.
• Vitale SG, Haimovich S, Laganà AS, Alonso L, Di Spiezio Sardo A, Carugno J. From the Global Community of Hysteroscopy Guidelines Committee. Endometrial polyps. An evidence-based diagnosis and management guide. Eur J Obstet Gynecol Reprod Biol 2021; 260: 70-7.
• Raz N, Feinmesser L, Moore O, Haimovich S. Endometrial polyps: diagnosis and treatment options - a review of literature. Minim Invasive Ther Allied Technol 2021; 30: 278-87.
• Okamura A, Yano E, Isono W, et al. Predictive factors of spontaneously regressed uterine endometrial polyps during the waiting period before hysteroscopic polypectomy. J Med Case Rep 2021; 15: 384.
• Guo L, Gu F, Tan J, Luo L, Gao J, Zhou C. Multiple endometrial polyps is associated with higher risk of chronic endometritis in reproductive-aged women. J Obstet Gynaecol Res 2021; 47: 389-96.
• Sheng KK, Lyons SD. To treat or not to treat? An evidence-based practice guide for the management of endometrial polyps. Climacteric 2020; 23: 336-42.
• Ludwin A, Lindheim S, Booth R, Ludwin I. Removal of uterine polyps: clinical management and surgical approach. Climacteric 2020; 23: 388-96.
• Lin S, Xie X, Guo Y, et al. Clinical characteristics and pregnancy outcomes of infertile patients with endometriosis and endometrial polyps: A retrospective cohort study. Taiwan J Obstet Gynecol 2020; 59: 916-21.
• Kossaï M, Penault-Llorca F. Role of hormones in common benign uterine lesions: endometrial polyps, leiomyomas, and adenomyosis. Adv Exp Med Biol 2020; 1242: 37-58.
• Ciscato A, Zare SY, Fadare O. The significance of recurrence in endometrial polyps: a clinicopathologic analysis. Hum Pathol 2020; 100: 38-44.
• Zhu Y, Liu Z, Du M, Yi L, Gong G, Tang X. Macrophages in patients with recurrent endometrial polyps could exacerbate Th17 responses. Clin Exp Pharmacol Physiol 2018; 45: 1128-34.
• Munro MG. Uterine polyps, adenomyosis, leiomyomas, and endometrial receptivity. Fertil Steril 2019; 111: 629-40.
• Zhang YN, Zhang YS, Yu Q, Guo ZZ, Ma JL, Yan L. Higher Prevalence of Endometrial Polyps in Infertile Patients with Endometriosis. Gynecol Obstet Invest 2018; 83: 558-63.
• Kilicdag EB, Haydardedeoglu B, Cok T, Parlakgumus AH, Simsek E, Bolat FA. Polycystic ovary syndrome and increased polyp numbers as risk factors for malignant transformation of endometrial polyps in premenopausal women. Int J Gynaecol Obstet 2011; 112: 200-3.
• Zheng QM, Mao HI, Zhao YJ, Zhao J, Wei X, Liu PS. Risk of endometrial polyps in women with endometriosis: a meta-analysis. Reprod Biol Endocrinol 2015; 13: 103.