Evaluation of prognostic factors of sex cord stromal tumors: a single-center experience

Belma Gözde Özdemir; Meltem Aydoğdu; Rabia Nur Sağlam; İpek Münteha Erdemli Kara; Duygu Çalık; Murat Çelik; Mustafa Gazi Uçar; Ahmet Bilgi; Çetin Çelik

doi:10.47582/jompac.1887249

Evaluation of prognostic factors of sex cord stromal tumors: a single-center experience

Abstract

Aims: Sex cord stromal tumors (SCSTs) constitute a rare subgroup of ovarian tumors, exhibiting heterogeneous clinical course and prognosis. The aim of this study is to evaluate clinicopathological factors affecting prognosis in patients with SCSTs based on single-center experience. Methods: This retrospective study included patients diagnosed with SCSTs at Selçuk University between 2010-2025. Demographic characteristics, tumor type, tumor stage, tumor size, mitotic index, surgical approach, adjuvant therapy status, and follow-up duration were recorded. Factors affecting prognosis were analyzed in terms of overall survival and disease-free survival. Results: A total of 94 patients with ovarian SCSTs were included in the study. Granulosa cell tumors constituted the most common histopathological subtype (n=41, 43.6%), followed by fibroma/thecoma (n=25, 26.6%) and other SCSTs (n=28, 29.8%). The mean age at diagnosis was 58.0±14.6 years. Tumor recurrence was observed in 5 patients (5.3%). At the last follow-up, 79 patients (84.0%) were alive and 15 patients (16.0%) had died. Adjuvant therapy was administered to 6 patients (6.4%), all of whom belonged to the other SCST group. Recurrence and mortality were more frequently observed in granulosa cell tumor and other SCST subgroups. Conclusion: In SCSTs, stage, mitotic activity, and residual disease after surgery are important factors in determining prognosis. Early diagnosis and optimal cytoreduction positively influence disease-free and overall survival. Larger patient series and multicenter studies with long-term follow-up are needed.

Keywords

Supporting Institution

none

Project Number

none

Ethical Statement

Ethical approval Number: E-70632468-050.01-1192823

Thanks

No conflict of interest.

References

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Details

Primary Language

English

Subjects

Obstetrics and Gynaecology

Journal Section

Research Article

Authors

Belma Gözde Özdemir ^*
0000-0002-7025-4087
Türkiye

Meltem Aydoğdu
0000-0002-2364-6870
Türkiye

Rabia Nur Sağlam
0009-0009-4611-0487
Türkiye

İpek Münteha Erdemli Kara
0009-0001-4535-0368
Türkiye

Duygu Çalık
0009-0008-9259-4710
Türkiye

Murat Çelik
Türkiye

Mustafa Gazi Uçar
0000-0002-6888-0206
Türkiye

Ahmet Bilgi
0000-0001-8682-1739
Türkiye

Çetin Çelik
Türkiye

Publication Date

March 27, 2026

Submission Date

February 16, 2026

Acceptance Date

March 12, 2026

Published in Issue

Year 2026 Volume: 7 Number: 2

DOI

https://doi.org/10.47582/jompac.1887249

IZ

https://izlik.org/JA82PM66FY

Cite

RIS / Bibtex

APA

Özdemir, B. G., Aydoğdu, M., Sağlam, R. N., Erdemli Kara, İ. M., Çalık, D., Çelik, M., Uçar, M. G., Bilgi, A., & Çelik, Ç. (2026). Evaluation of prognostic factors of sex cord stromal tumors: a single-center experience. Journal of Medicine and Palliative Care, 7(2), 344-348. https://doi.org/10.47582/jompac.1887249

AMA

1.Özdemir BG, Aydoğdu M, Sağlam RN, et al. Evaluation of prognostic factors of sex cord stromal tumors: a single-center experience. J Med Palliat Care / JOMPAC / jompac. 2026;7(2):344-348. doi:10.47582/jompac.1887249

Chicago

Özdemir, Belma Gözde, Meltem Aydoğdu, Rabia Nur Sağlam, et al. 2026. “Evaluation of Prognostic Factors of Sex Cord Stromal Tumors: A Single-Center Experience”. Journal of Medicine and Palliative Care 7 (2): 344-48. https://doi.org/10.47582/jompac.1887249.

EndNote

Özdemir BG, Aydoğdu M, Sağlam RN, Erdemli Kara İM, Çalık D, Çelik M, Uçar MG, Bilgi A, Çelik Ç (March 1, 2026) Evaluation of prognostic factors of sex cord stromal tumors: a single-center experience. Journal of Medicine and Palliative Care 7 2 344–348.

IEEE

[1]B. G. Özdemir et al., “Evaluation of prognostic factors of sex cord stromal tumors: a single-center experience”, J Med Palliat Care / JOMPAC / jompac, vol. 7, no. 2, pp. 344–348, Mar. 2026, doi: 10.47582/jompac.1887249.

ISNAD

Özdemir, Belma Gözde - Aydoğdu, Meltem - Sağlam, Rabia Nur - Erdemli Kara, İpek Münteha - Çalık, Duygu - Çelik, Murat - Uçar, Mustafa Gazi - Bilgi, Ahmet - Çelik, Çetin. “Evaluation of Prognostic Factors of Sex Cord Stromal Tumors: A Single-Center Experience”. Journal of Medicine and Palliative Care 7/2 (March 1, 2026): 344-348. https://doi.org/10.47582/jompac.1887249.

JAMA

1.Özdemir BG, Aydoğdu M, Sağlam RN, Erdemli Kara İM, Çalık D, Çelik M, Uçar MG, Bilgi A, Çelik Ç. Evaluation of prognostic factors of sex cord stromal tumors: a single-center experience. J Med Palliat Care / JOMPAC / jompac. 2026;7:344–348.

MLA

Özdemir, Belma Gözde, et al. “Evaluation of Prognostic Factors of Sex Cord Stromal Tumors: A Single-Center Experience”. Journal of Medicine and Palliative Care, vol. 7, no. 2, Mar. 2026, pp. 344-8, doi:10.47582/jompac.1887249.

Vancouver

1.Belma Gözde Özdemir, Meltem Aydoğdu, Rabia Nur Sağlam, İpek Münteha Erdemli Kara, Duygu Çalık, Murat Çelik, Mustafa Gazi Uçar, Ahmet Bilgi, Çetin Çelik. Evaluation of prognostic factors of sex cord stromal tumors: a single-center experience. J Med Palliat Care / JOMPAC / jompac. 2026 Mar. 1;7(2):344-8. doi:10.47582/jompac.1887249