In this study, acetate derivatives were obtained from the reaction of acetophenones using diethyl carbonate. The acidic proton of CH2 moiety was abstracted using a suitable base and α-propargyl-β-ketoester (non-conjugated ynone) derivatives 3a-c were obtained from the reaction of the acetate derivatives with propargyl bromide. By removing the ester group of α propargyl-β-ketoester derivatives under suitable conditions, α-propargyl acetophenones (non-conjugated ynone) 4a-c were obtained. In this study, 6 different unconjugated ynone derivatives were synthesized as starting material with yield in a range of 60-95%. Cyclization reactions with propargyl amine in the presence of three different unconjugated ynone derivatives, metal catalysts were investigated. The synthesis of propargyl pyrroles 7a-c having substituents on C-2 and C-5 was completed.
The author thanks to Science Research and Applied Center in Van Yüzüncü Yil University for their research facilities.
Birincil Dil | İngilizce |
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Konular | Organik Kimya |
Bölüm | Makaleler |
Yazarlar | |
Yayımlanma Tarihi | 31 Mayıs 2022 |
Gönderilme Tarihi | 28 Ocak 2022 |
Kabul Tarihi | 22 Mart 2022 |
Yayımlandığı Sayı | Yıl 2022 |