Green and Efficient Benzylation of Amines Using Copper Catalysts under Microwave Irradiation

Mohamed El Hadi Benhalouche; Abdellah Miloudi; Hasan Küçükbay

doi:10.18596/jotcsa.1905724

Green and Efficient Benzylation of Amines Using Copper Catalysts under Microwave Irradiation

Abstract

N-Benzylation of aliphatic, aromatic, and heteroaromatic amines was performed in the presence of metallic copper and environmentally benign bases by conventional and microwave heating. The ethanol-water mixture was found to be a suitable solvent, enabling improved product formation, especially under microwave irradiation. We obtained with this protocol a good conversion (up to 86%) in only 6 h, the time was reduced to 30 min under microwave irradiation. The steric and electronic effects were also explored to provide further insight into the suitability of these protocols. The catalyst was recovered and reused to afford the product without significant loss of mass and catalytic properties.

Keywords

Thanks

Our thanks are Professor Henri DOUCET Researcher director and team leader in the catalysis and organometallic laboratory in Rennes, France, which have done in the framework of collaboration, elemental analyses and 1H and 13C NMRs measurements.

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Details

Primary Language

English

Subjects

Organic Chemical Synthesis

Journal Section

Research Article

Authors

Mohamed El Hadi Benhalouche
0000-0002-5466-721X
Algeria

Abdellah Miloudi
0000-0003-3519-6675
Algeria

Hasan Küçükbay ^*
0000-0002-7180-9486
Türkiye

Publication Date

June 3, 2026

Submission Date

March 9, 2026

Acceptance Date

May 6, 2026

Published in Issue

Year 2026 Volume: 2026 Number: 2

DOI

https://doi.org/10.18596/jotcsa.1905724

IZ

https://izlik.org/JA35XX28JM

Cite

RIS / Bibtex

APA

Benhalouche, M. E. H., Miloudi, A., & Küçükbay, H. (2026). Green and Efficient Benzylation of Amines Using Copper Catalysts under Microwave Irradiation. Journal of the Turkish Chemical Society Section A: Chemistry, 2026(2), 1-17. https://doi.org/10.18596/jotcsa.1905724

AMA

1.Benhalouche MEH, Miloudi A, Küçükbay H. Green and Efficient Benzylation of Amines Using Copper Catalysts under Microwave Irradiation. JOTCSA. 2026;2026(2):1-17. doi:10.18596/jotcsa.1905724

Chicago

Benhalouche, Mohamed El Hadi, Abdellah Miloudi, and Hasan Küçükbay. 2026. “Green and Efficient Benzylation of Amines Using Copper Catalysts under Microwave Irradiation”. Journal of the Turkish Chemical Society Section A: Chemistry 2026 (2): 1-17. https://doi.org/10.18596/jotcsa.1905724.

EndNote

Benhalouche MEH, Miloudi A, Küçükbay H (June 1, 2026) Green and Efficient Benzylation of Amines Using Copper Catalysts under Microwave Irradiation. Journal of the Turkish Chemical Society Section A: Chemistry 2026 2 1–17.

IEEE

[1]M. E. H. Benhalouche, A. Miloudi, and H. Küçükbay, “Green and Efficient Benzylation of Amines Using Copper Catalysts under Microwave Irradiation”, JOTCSA, vol. 2026, no. 2, pp. 1–17, June 2026, doi: 10.18596/jotcsa.1905724.

ISNAD

Benhalouche, Mohamed El Hadi - Miloudi, Abdellah - Küçükbay, Hasan. “Green and Efficient Benzylation of Amines Using Copper Catalysts under Microwave Irradiation”. Journal of the Turkish Chemical Society Section A: Chemistry 2026/2 (June 1, 2026): 1-17. https://doi.org/10.18596/jotcsa.1905724.

JAMA

1.Benhalouche MEH, Miloudi A, Küçükbay H. Green and Efficient Benzylation of Amines Using Copper Catalysts under Microwave Irradiation. JOTCSA. 2026;2026:1–17.

MLA

Benhalouche, Mohamed El Hadi, et al. “Green and Efficient Benzylation of Amines Using Copper Catalysts under Microwave Irradiation”. Journal of the Turkish Chemical Society Section A: Chemistry, vol. 2026, no. 2, June 2026, pp. 1-17, doi:10.18596/jotcsa.1905724.

Vancouver

1.Mohamed El Hadi Benhalouche, Abdellah Miloudi, Hasan Küçükbay. Green and Efficient Benzylation of Amines Using Copper Catalysts under Microwave Irradiation. JOTCSA. 2026 Jun. 1;2026(2):1-17. doi:10.18596/jotcsa.1905724