Chalcone Derivatives for Optoelectronic Materials: A Mini Review
Abstract
Chalcone derivatives have attracted increasing interest due to their versatile structural features and adjustable electronic properties, making them valuable scaffolds in both medicinal and materials chemistry. This class of compounds forms the central core of important biological molecules due to the presence of an α, β-unsaturated carbonyl system in their structures. Such a structural feature allows electrons to be delocalized within the molecule, giving chalcone derivatives tunable optical and electronic properties. While chalcones are widely known for their diverse biological activities, increasing attention has recently been directed toward their applications in materials science, particularly in optoelectronic technologies. This review summarizes recent developments in the non-biological applications of chalcone derivatives. Brief information on the classical synthesis of chalcones, particularly the Claisen–Schmidt condensation, is also presented. Particular emphasis is placed on the optoelectronic potential of chalcone-based systems for applications such as organic light-emitting diodes (OLEDs), photodiodes (PDs), dye-sensitized solar cells (DSSCs), and nonlinear optical materials (NLOs).
Keywords
References
- 1. Rudrapal M, Khan J, Dukhyil AA Bin, Alarousy RMII, Attah EI, Sharma T, et al. Chalcone scaffolds, bioprecursors of flavonoids: Chemistry, bioactivities, and pharmacokinetics. Molecules. 2021 Nov 26;26(23):7177. Available from:
. - 2. Toublet FX, Laurent A, Pouget C. A review of natural and synthetic chalcones as anticancer agents targeting topoisomerase enzymes. Molecules. 2025 Jun 6;30(12):2498. Available from:
. - 3. Debnath S, Das SK, Singh J, Alam N, Kumari B, Saharia N, et al. The role of chalcones in modern medicinal chemistry: A review of their potential and biological activity. Int J Pharm Sci. 2025;3(1):2289–97. Available from:
. - 4. Claisen L, Claparède A. Condensationen von ketonen mit aldehyden. Berichte der Dtsch Chem Gesellschaft. 1881 Jul 28;14(2):2460–8. Available from:
. - 5. Schmidt JG. Ueber die einwirkung von aceton auf furfurol und auf bittermandelöl bei gegenwart von alkalilauge. Berichte der Dtsch Chem Gesellschaft. 1881 Jan 28;14(1):1459–61. Available from:
. - 6. Asiri AM, Marwani HM, Alamry KA, Al-Amoudi MS, Khan SA, El-Daly SA. Green synthesis, characterization, photophysical and electrochemical properties of bis-chalcones. Int J Electrochem Sci. 2014 Feb 1;9(2):799–809. Available from:
. - 7. Farooq S, Ngaini Z, Mortadza NA. Microwave‐assisted synthesis and molecular docking study of heteroaromatic chalcone derivatives as potential antibacterial agents. Bull Korean Chem Soc. 2020 Sep 8;41(9):918–24. Available from:
. - 8. Saraci E, Andreoli M, Casali E, Verzini M, Argese M, Fanelli R, et al. Solvent-free synthesis of chalcones using Mg(HSO4)2. RSC Sustain. 2023 May 11;1(3):504–10. Available from:
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Details
Primary Language
English
Subjects
Inorganic Chemistry (Other)
Journal Section
Review
Authors
Lütfiye Sirka
*
0000-0003-3973-6675
Türkiye
Publication Date
July 19, 2026
Submission Date
March 10, 2026
Acceptance Date
May 21, 2026
Published in Issue
Year 2026 Volume: 2026 Number: 2
