Research Article

Comparative Phytochemical Profiling and Antimicrobial Activity of the Essential Oil and Hexane Extract of Artemisia turanica from Uzbekistan

Volume: 2026 Number: 2 November 4, 2026

Comparative Phytochemical Profiling and Antimicrobial Activity of the Essential Oil and Hexane Extract of Artemisia turanica from Uzbekistan

Abstract

Artemisia turanica Krash. is one of the dominant essential oil-bearing species of the Kyzylkum Desert in Uzbekistan. Although the chemical composition of essential oils from several Iranian populations has previously been investigated, the phytochemical profile of A. turanica growing in Uzbekistan and other parts of Central Asia has remained unknown. The present study provides the first comprehensive characterization of the hydrophobic constituents of the Uzbek population of A. turanica. The chemical compositions of the essential oil (EO) and hexane extract (HE) obtained from the aerial parts were analyzed by GC–MS, and their antimicrobial and antifungal activities were evaluated using the agar disc diffusion method. A total of 82 compounds, including monoterpenoids, sesquiterpenoids (including biologically active sesquiterpene lactones), triterpenoids, hydrocarbons, and fatty acids with their esters, were tentatively identified. Among them, 69 compounds have not previously been reported in A. turanica. Comparative analysis with previously published data revealed substantial qualitative differences between the Uzbek and Iranian populations and suggests that the Uzbek population may represent a distinct 1,8-cineole–endo-borneol chemotype. Both samples produced inhibition zones against the tested microorganisms, whereas the EO exhibited markedly greater inhibitory activity than the HE. The strongest inhibitory effects were observed against Staphylococcus aureus (15.08 ± 0.12 mm) and Candida albicans (18.04 ± 0.10 mm). These findings expand current knowledge of the chemical diversity of A. turanica, provide the first phytochemical data for its Uzbek population, and indicate its potential as a source of biologically active hydrophobic constituents.

Keywords

Thanks

This work was supported by the Uzbek-Chinese joint fundamental research grant No. CAM202403, entitled “Study on sesquiterpenoid constituents from Artemisia and investigation of plant resources endemic to Uzbekistan” and by the Basic Scientific Research Program of the Academy of Sciences of the Republic of Uzbekistan.

References

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Details

Primary Language

English

Subjects

Natural Products and Bioactive Compounds

Journal Section

Research Article

Publication Date

November 4, 2026

Submission Date

March 27, 2026

Acceptance Date

October 9, 2026

Published in Issue

Year 2026 Volume: 2026 Number: 2

APA
Sham’yanov, I., Bobakulov, K., Mukhamatkhanova, R. F., Begmatov, N., Sasmakov, S., Azimova, S., & Abdullaev, N. (2026). Comparative Phytochemical Profiling and Antimicrobial Activity of the Essential Oil and Hexane Extract of Artemisia turanica from Uzbekistan. Journal of the Turkish Chemical Society Section A: Chemistry, 2026(2). https://doi.org/10.18596/jotcsa.1917446
AMA
1.Sham’yanov I, Bobakulov K, Mukhamatkhanova RF, et al. Comparative Phytochemical Profiling and Antimicrobial Activity of the Essential Oil and Hexane Extract of Artemisia turanica from Uzbekistan. JOTCSA. 2026;2026(2). doi:10.18596/jotcsa.1917446
Chicago
Sham’yanov, Ildar, Khayrulla Bobakulov, Rimma F. Mukhamatkhanova, et al. 2026. “Comparative Phytochemical Profiling and Antimicrobial Activity of the Essential Oil and Hexane Extract of Artemisia Turanica from Uzbekistan”. Journal of the Turkish Chemical Society Section A: Chemistry 2026 (2). https://doi.org/10.18596/jotcsa.1917446.
EndNote
Sham’yanov I, Bobakulov K, Mukhamatkhanova RF, Begmatov N, Sasmakov S, Azimova S, Abdullaev N (November 1, 2026) Comparative Phytochemical Profiling and Antimicrobial Activity of the Essential Oil and Hexane Extract of Artemisia turanica from Uzbekistan. Journal of the Turkish Chemical Society Section A: Chemistry 2026 2
IEEE
[1]I. Sham’yanov et al., “Comparative Phytochemical Profiling and Antimicrobial Activity of the Essential Oil and Hexane Extract of Artemisia turanica from Uzbekistan”, JOTCSA, vol. 2026, no. 2, Nov. 2026, doi: 10.18596/jotcsa.1917446.
ISNAD
Sham’yanov, Ildar - Bobakulov, Khayrulla - Mukhamatkhanova, Rimma F. - Begmatov, Nurmirza - Sasmakov, Sobirdjan - Azimova, Shakhnoz - Abdullaev, Nasrulla. “Comparative Phytochemical Profiling and Antimicrobial Activity of the Essential Oil and Hexane Extract of Artemisia Turanica from Uzbekistan”. Journal of the Turkish Chemical Society Section A: Chemistry 2026/2 (November 1, 2026). https://doi.org/10.18596/jotcsa.1917446.
JAMA
1.Sham’yanov I, Bobakulov K, Mukhamatkhanova RF, Begmatov N, Sasmakov S, Azimova S, Abdullaev N. Comparative Phytochemical Profiling and Antimicrobial Activity of the Essential Oil and Hexane Extract of Artemisia turanica from Uzbekistan. JOTCSA. 2026;2026. doi:10.18596/jotcsa.1917446.
MLA
Sham’yanov, Ildar, et al. “Comparative Phytochemical Profiling and Antimicrobial Activity of the Essential Oil and Hexane Extract of Artemisia Turanica from Uzbekistan”. Journal of the Turkish Chemical Society Section A: Chemistry, vol. 2026, no. 2, Nov. 2026, doi:10.18596/jotcsa.1917446.
Vancouver
1.Ildar Sham’yanov, Khayrulla Bobakulov, Rimma F. Mukhamatkhanova, Nurmirza Begmatov, Sobirdjan Sasmakov, Shakhnoz Azimova, Nasrulla Abdullaev. Comparative Phytochemical Profiling and Antimicrobial Activity of the Essential Oil and Hexane Extract of Artemisia turanica from Uzbekistan. JOTCSA. 2026 Nov. 1;2026(2). doi:10.18596/jotcsa.1917446