Synthesis and Bioactivity of Novel Fused Heterocyclic Compounds Derived from Benzo[d][1,3]dioxol-5-amine

Mohammed Ahmed Khalaf; Amena Alyas Ahmed

doi:10.18596/jotcsa.1970025

Synthesis and Bioactivity of Novel Fused Heterocyclic Compounds Derived from Benzo[d][1,3]dioxol-5-amine

Abstract

This research includes the synthesis of chalcones due to their importance in organic chemistry; certain intermediates are used to form heterocyclic. Firstly, synthesis compound A1 was synthesized by the reaction between Benzo[d][1,3]dioxol-5-amine and chloroacetyl chloride. Then, cyclization by ammonium isothiocyanate is performed using acetone as a solvent to get compound A2. This compound contains an activated α-H that reacts with sub. Aldehyde, also glacial acetic acid & sodium acetate to yield (A3-A6). It can cyclize to fused heterocyclic compounds by reacting with hydrazine hydrate to obtain (A7-A10). Finally, to form (A11-A14) pyrimidin-thione derivatives, compound (A3-A6) was reacted with thiourea. Identification of (A1-A14) by spectroscopy (IR, H-NMR) was tested; their bioactivity against two types of bacteria, E. coli and S. aureus. Compounds A10,A11,A12 exhibited considerable inhibitory activity against S. aureus, with inhibition zones of (44, 32, 36) mm, respectively. In contrast, the antibacterial assay against E. coli showed that compounds A11, A12 produced inhibition zones of 22 and 20 mm, respectively. These findings indicate that the tested compounds exhibited variable antibacterial activity depending on the bacterial strain.

Keywords

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References

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Details

Primary Language

English

Subjects

Organic Chemistry (Other)

Journal Section

Research Article

Authors

Mohammed Ahmed Khalaf This is me
Iraq

Amena Alyas Ahmed ^*
0000-0003-3153-071X
Iraq

Publication Date

October 22, 2026

Submission Date

June 13, 2026

Acceptance Date

August 30, 2026

Published in Issue

Year 2026 Volume: 2026 Number: 2

DOI

https://doi.org/10.18596/jotcsa.1970025

IZ

https://izlik.org/JA48LN46NS

Cite

RIS / Bibtex

APA

Khalaf, M. A., & Alyas Ahmed, A. (2026). Synthesis and Bioactivity of Novel Fused Heterocyclic Compounds Derived from Benzo[d][1,3]dioxol-5-amine. Journal of the Turkish Chemical Society Section A: Chemistry, 2026(2), 1-17. https://doi.org/10.18596/jotcsa.1970025

AMA

1.Khalaf MA, Alyas Ahmed A. Synthesis and Bioactivity of Novel Fused Heterocyclic Compounds Derived from Benzo[d][1,3]dioxol-5-amine. JOTCSA. 2026;2026(2):1-17. doi:10.18596/jotcsa.1970025

Chicago

Khalaf, Mohammed Ahmed, and Amena Alyas Ahmed. 2026. “Synthesis and Bioactivity of Novel Fused Heterocyclic Compounds Derived from Benzo[d][1,3]dioxol-5-Amine”. Journal of the Turkish Chemical Society Section A: Chemistry 2026 (2): 1-17. https://doi.org/10.18596/jotcsa.1970025.

EndNote

Khalaf MA, Alyas Ahmed A (October 1, 2026) Synthesis and Bioactivity of Novel Fused Heterocyclic Compounds Derived from Benzo[d][1,3]dioxol-5-amine. Journal of the Turkish Chemical Society Section A: Chemistry 2026 2 1–17.

IEEE

[1]M. A. Khalaf and A. Alyas Ahmed, “Synthesis and Bioactivity of Novel Fused Heterocyclic Compounds Derived from Benzo[d][1,3]dioxol-5-amine”, JOTCSA, vol. 2026, no. 2, pp. 1–17, Oct. 2026, doi: 10.18596/jotcsa.1970025.

ISNAD

Khalaf, Mohammed Ahmed - Alyas Ahmed, Amena. “Synthesis and Bioactivity of Novel Fused Heterocyclic Compounds Derived from Benzo[d][1,3]dioxol-5-Amine”. Journal of the Turkish Chemical Society Section A: Chemistry 2026/2 (October 1, 2026): 1-17. https://doi.org/10.18596/jotcsa.1970025.

JAMA

1.Khalaf MA, Alyas Ahmed A. Synthesis and Bioactivity of Novel Fused Heterocyclic Compounds Derived from Benzo[d][1,3]dioxol-5-amine. JOTCSA. 2026;2026:1–17.

MLA

Khalaf, Mohammed Ahmed, and Amena Alyas Ahmed. “Synthesis and Bioactivity of Novel Fused Heterocyclic Compounds Derived from Benzo[d][1,3]dioxol-5-Amine”. Journal of the Turkish Chemical Society Section A: Chemistry, vol. 2026, no. 2, Oct. 2026, pp. 1-17, doi:10.18596/jotcsa.1970025.

Vancouver

1.Mohammed Ahmed Khalaf, Amena Alyas Ahmed. Synthesis and Bioactivity of Novel Fused Heterocyclic Compounds Derived from Benzo[d][1,3]dioxol-5-amine. JOTCSA. 2026 Oct. 1;2026(2):1-17. doi:10.18596/jotcsa.1970025

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