Synthesis and comparative antibacterial studies of some benzylidene monosaccharide benzoates

Abstract

Some 4,6-O-benzylidene protected 2,3-di-O-benzoates of methyl a-D-glucopyranoside and methyl a-D-mannopyranoside were prepared. All the compounds (1-7) were screened for in vitro antibacterial activity study against ten human pathogenic bacteria. The study revealed that the benzoylated mannopyranosides (5-7) are more prone towards antibacterial functionalities than that of the glucopyranosides (2-3).

Keywords

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Bazı benziliden monosakkarit benzoatların sentezi ve karşılaştırmalı antibakteriyel çalışmaları

Abstract

Metil a-D-glukopiranozid ve metil a-D-mannopiranozidin 4,6-O-benziliden ile korunmuş 2,3-di-O-benzoatları hazırlanmıştır. Bütün bileşikler (1-7) on adet insana karşı patojenik bakteriye karşı in vitro antibakteriyel aktivite çalışması için görüntülenmiştir. Çalışmaya göre, benzoillenmiş mannopiranozidler (5-7) glukopiranozidlere (2-3) karşı antibakteriyel işlevsellik bakımından daha narindir.

Keywords

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