Total Syntheses of Balsacone B and Balsacone C

Abstract

The first total syntheses of Balsacone C (16) and Balsacone B (17), mainly based on a convergent strategy, were described. The crucial step of this strategy was the alkylation of trihydroxydihydrochalcone derivatives 7 and 8 with cinnamylbromide derivative 13. For this, compounds 7 and 8 were prepared starting from trihydroxyacetophenone (1) in four steps. Then compound 13 was prepared starting from coumaric acid (9) in four steps.      

Keywords

• Synthesis
• natural product
• Balsacone B
• Balsacone C

References

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