A Novel ZnO Nanoparticle as Drug Nanocarrier in Therapeutic applications: Kinetic Models and Error Analysis

Abstract

Nanotechnology provides promising possibilities for several biomedical and pharmaceutical  applications in the medicine industry. Nanostructures play a major role in the recent strategies of  technology suitable for novel drug applications. In this work, clindamycin phosphate (CliP) (topical anti-inflammatory drug), xanthan gum (XaG) (biopolymer) and ZnO (zinc oxide) (nanoparticle) nanostructures were synthesised using the sonochemical technique at room temperature. The characterization of the clindamycin phosphate- xanthan gum/ZnO (CliP-XaG/ZnO) nanostructure has been carried out by Fourier transform infrared (FTIR) and X-ray diffraction (XRD). The spectroscopic experiments elucidated in vitro the mechanism of drug delivery system at different pH media (1.2 and 7.4). In this study, the concentration of drug in the solution was analyzed by UV–vis spectroscopy method and several kinetic models and error analysis were calculated to prove a connection with results. The Higuchi model had the best correlation parameters. The percentage of swelling ratio (%) reached up 105% in XaG (pH 1.2) and 190% in XaG/ZnO (pH 1.2) And the swelling ratio (%) reached up 530% within in XaG (pH 7.4) and 655% within in XaG/ZnO (pH 7.4). The results show that the capacity of XaG / ZnO can be preferred as a novel topical anti-inflammatory drug carrier. 

Keywords

• Xanthan gum,controlled drug delivery,sonochemistry,ZnO

References

1. 1. Zhang Y, Chan HF, Leong KW. Advanced materials and processing for drug delivery: The past and the future. Advanced Drug Delivery Reviews. 2013 (65):104–20.
2. 2. Treesuppharat W, Rojanapanthua P, Siangsanoh C, Manuspiya H, Ummartyotin S. Synthesis and characterization of bacterial cellulose and gelatin-based hydrogel composites for drug-delivery systems, Biotechnology Reports. 2017 (15):84–91.
3. 3. Zhao L, Shen G, Ma G, Yan X. Engineering and delivery of nanocolloids of hydrophobic drugs. Advances in Colloid and Interface Science. 2017 (249):308–20.
4. 4. Shariatinia Z, Zahraee Z. Controlled release of metformin from chitosan–based nanocomposite films containing mesoporous MCM-41 nanoparticles as novel drug delivery systems. Journal of Colloid and Interface Science. 2017 (501):60–76.
5. 5. Joshy KS, Snigdha S, Kalarikkal N, Pothen LA, Thomas S. Gelatin modified lipid nanoparticles for anti- viral drug delivery. Chemistry and Physics of Lipids. 207 (2017):24–37.
6. 6. Ribeiro LNM, Alcântara ACS, Darder M, Aranda P, Herrmann PSP, Araújo-Moreira FM, García-Hernández M, Ruiz-Hitzky E. Bionanocomposites containing magnetic graphite as potential systems for drug delivery. International Journal of Pharmaceutics. 2014 (477):553–63.
7. 7. Park S, Mun S, Kim YR. Effect of xanthan gum on lipid digestion and bioaccessibility of β-carotene loaded rice starch-based filled hydrogels. Food Research International. 2018 (105):440–5.
8. 8. Sharma K, Kumar V, Chaudhary B, Kaith BS, Kalia S, Swart HC. Application of biodegradable super absorbent hydrogel composite based on Gum ghatti-co-poly(acrylic acid-aniline) for controlled drug delivery. Polymer Degradation and Stability. 2016 (124):101-11.

9. 9. Hosseini MS, Hemmati K, Ghaemy M. Synthesis of nanohydrogels based on tragacanth gum biopolymer and investigation of swelling and drug delivery. International Journal of Biological Macromolecules. 2016 (82):806–15.
10. 10. Zare-Akbari Z, Farhadnejad H, Furughi-Nia B, Abedin S, Yadollahi M, Khorsand-Ghayeni M. PH-sensitive bionanocomposite hydrogel beads based on carboxymethyl cellulose/ZnO nanoparticle as drug carrier. International Journal of Biological Macromolecules. 2016 (93):1317–27.
11. 11. Ay AN, Konuk D, Zümreoğlu-Karan B. Magnetic nanocomposites with drug-intercalated layered double hydroxide shell supported on commercial magnetite and laboratory-made magnesium ferrite core materials. Materials Science and Engineering: C. 2011, 31(5):851-7.
12. 12. Oliveira AS, Alcântara ACS, Pergher SBC. Bionanocomposite systems based on montmorillonite and biopolymers for the controlled release of olanzapine. Materials Science and Engineering: C. 2017 (75):1250–8.
13. 13. Zhang M, Liu J, Kuang Y, Li Q, Zheng DW, Song Q, Chena H, Chen X, Xu Y, Li C, Jiang B. Ingenious pH-sensitive dextran/mesoporous silica nanoparticles based drug delivery systems for controlled intracellular drug release. International Journal of Biological Macromolecules. 2017 (98):691–700.
14. 14. El-Naggar AWM, Senna MM, Mostafa TA, Helal RH. Radiation synthesis and drug delivery properties of interpenetrating networks (IPNs) based on poly(vinyl alcohol)/ methylcellulose blend hydrogels. International Journal of Biological Macromolecules. 2017 (102):1045–51.
15. 15. Bajpai SK, Jadaun M, Bajpai M, Jyotishi P, Shah FF, Tiwari S. Controlled release of Doxycycline from gum acacia/poly(sodium acrylate) microparticles for oral drug delivery. International Journal of Biological Macromolecules. 2017 (104):1064–71.
16. 16. Wang R, Shou D, Lv O, Kong Y, Deng L, Shen J. pH-Controlled drug delivery with hybrid aerogel of chitosan, carboxymethyl cellulose and graphene oxide as the carrier. International Journal of Biological Macromolecules. 2017 (103):248–53.
17. 17. Singh B, Sharma V. Crosslinking of poly(vinylpyrrolidone)/acrylic acid with tragacanth gum for hydrogels formation for use in drug delivery applications. Carbohydrate Polymers. 2017 (157):185–95.
18. 18. Qin SY, Zhang AQ, Cheng SX, Rong L, Zhang XZ. Drug self-delivery systems for cancer therapy. Biomaterials. 2017 (112):234-47.
19. 19. Garcia-Ochoa F, Santos VE, Alon A. Xanthan gum production:An unstructured kinetic model. Enzyme and Microbial Technology. 1995 (17):206-17.
20. 20. Cai Y, Deng X, Liu T, Zhao M, Zhao Q, Chen S. Effect of xanthan gum on walnut protein/xanthan gum mixtures, interfacial adsorption, and emulsion properties. Food Hydrocolloids. 2018 (79):391-8.
21. 21. Jang HY, Zhang K, Chon BH, Choi HJ. Enhanced oil recovery performance and viscosity characteristics of polysaccharide xanthan gum solution. Journal of Industrial and Engineering Chemistry. 2015 (21):741–5.
22. 22. Kim M, Park JH. Enantioseparation of chiral acids and bases on a clindamycin phosphate-modified zirconia monolith by capillary electrochromatography. Journal of Chromatography A. 2012 (1251):244– 8.
23. 23. Gonzalez G, Sagarzazu A, Cordova A, Gomes ME, Salas J, Contreras L, Noris-Suarez K, Lascano L. Comparative study of two silica mesoporous materials (SBA-16 and SBA-15) modified with a hydroxyapatite layer for clindamycin controlled delivery. Microporous and Mesoporous Materials. 2018 (256):251-65.
24. 24. Tan E, Karakuş S, Pozan Soylu GS, Birer Ö, Zengin Y, Kilislioglu A. Formation and distribution of ZnO nanoparticles and its effect on E. Coli in the presence of sepiolite and silica within the chitosan matrix via sonochemistry. Ultrasonics Sonochemistry. 2017 (38):720-5.
25. 25. Sabbagh N, Akbari A, Arsalani N, Eftekhari-Sis B, Hamishekar H. Halloysite-based hybrid bionanocomposite hydrogels as potential drug delivery systems. Applied Clay Science. 2017 (148):48–55.
26. 26. Bigham A, Hassanzadeh-Tabrizi SA, Rafienia M, Salehi H. Ordered mesoporous magnesium silicate with uniform nanochannels as a drug delivery system: The effect of calcination temperature on drug delivery rate. Ceramics International. 2016 (42):17185–91.
27. 27. Parmar A, Sharma S. Engineering design and mechanistic mathematical models: Standpoint on cutting edge drug delivery. Trends in Analytical Chemistry. 2018 (100):15-35.
28. 28. Siepmann J, Siepmann F. Modeling of diffusion controlled drug delivery. Journal of Controlled Release. 2012 (161):351–62.
29. 29. Miastkowskaa M, Sikoraa E, Ogonowskia J, Zielinab M, Ludzik A. The kinetic study of isotretinoin release from nanoemulsion. Colloids and Surfaces A: Physicochem. Eng. Aspects. 2016 (510):63–8.
30. 30. F Kianfar, M Antonijevic, B Chowdhry, JS Boateng. Lyophilized wafers comprising carrageenan and pluronic acid for buccal drug delivery using model soluble and insoluble drugs. Colloids and Surfaces B: Biointerfaces. 2013 (103):99– 106.
31. 31. Gu C, Le V, Lang M, Liu J. Preparation of polysaccharide derivates chitosan-graft-poly(ε-caprolactone) amphiphilic copolymer micelles for 5-fluorouracil drug delivery. Colloids and Surfaces B: Biointerfaces. 2014 (116):745–50.
32. 32. Vilac N, Amorim R, Machado AF, Parpot P, Pereira MFR, Sardo M, Rocha J, Fonseca AM, Neves IC, Baltazar F. Potentiation of 5-fluorouracil encapsulated in zeolites as drug delivery systems for in vitro models of colorectal carcinoma. Colloids and Surfaces B: Biointerfaces. 2013 (112):237–44.
33. 33. Rehman F, Ahmed K, Airoldi C, Gaisford S, Buanz A, Rahim A, Muhammad N, Volpe PLO. Amine bridges grafted mesoporous silica, as a prolonged/controlled drug release system for the enhanced therapeutic effect of short life drugs. Materials Science and Engineering C. 2017 (72):34–41.
34. 34. Liu Y, Shah S, and Tan J. Computational Modeling of Nanoparticle Targeted Drug Delivery. Reviews in Nanoscience and Nanotechnology. 2012 (1):66–83.
35. 35. Jarosz M, Pawlik A, Szuwarzynski M, Jaskula M, Sulka GD. Nanoporous anodic titanium dioxide layers as potential drug delivery systems: Drug release kinetics and mechanism. Colloids and Surfaces B: Biointerfaces. 2016 (143):447–54.
36. 36. Bounabi L, Mokhnachi NB, Haddadine N, Ouazib F, Barille R. Development of poly(2-hydroxyethyl methacrylate)/clay composites as drug delivery systems of paracetamol. Journal of Drug Delivery Science and Technology. 2016 (33):58-65.
37. 37. Luo H, Ao H, Li G, Li W, Xiong G, Zhu Y, Wan Y. Bacterial cellulose/graphene oxide nanocomposite as a novel drug delivery system. Current Applied Physics. 2017 (17):249-54.
38. 38. Oun AA, Rhim JW. Carrageenan-based hydrogels and films: Effect of ZnO and CuO nanoparticles on the physical, mechanical, and antimicrobial properties. Food Hydrocoll. 2017 (67):45-53.
39. 39. Hashemi MM, Aminlari M, Moosavinasa M. Preparation of and studies on the functional properties and bactericidal activity of the lysozymee-xanthan gum conjugate. LWT - Food Science and Technology. 2014 (57):594-602.
40. 40. Benichou, A, Aserin, A, Lutz, R, & Garti, N. Formation and characterization of amphiphilic conjugates of whey protein isolate (WPI)/xanthan to improve surface activity. Food Hydrocolloids. 2007 (21):379-91.
41. 41. Demirbas E, Kobya M,. Konukman AES. Error analysis of equilibrium studies for the almond Shell activated carbon adsorption of Cr(VI) from aqueous solutions. Journal of Hazardous Materials. 2008;(154):787–94.
42. 42. Kapoor A, Yang RT. Correlation of equilibrium adsorption data of condensable vapours on porous adsorbents. Gas Sep. Purif. 1989 (3): 187–92.
43. 43. Tanyildizi MS. Modeling of adsorption isotherms and kinetics of reactive dye from aqueous solution by peanut hull. Chemical Engineering Journal. 2011 (168): 1234–40.
44. 44. Knorr D. Dye binding properties of chitin and chitosan. J Food Sci. 1983 (48):36–41.
45. 45. Carlough M, Hudson S, Smith B, Spadgenske D. Diffusion coefficients of direct dyes in chitosan. J Appl Polym Sci. 1991 (42): 3035–8.