Synthesis, Cytotoxicity and Molecular Docking Study of Complexes Containing Thiazole Moiety

Year 2017, Volume: 4 Issue: 3, 787 - 810, 31.07.2017

Mohammed Shafeeulla Ganganaik Krishnamurthy Halehatti S. Bhojynaik Manjuraj T

https://doi.org/10.18596/jotcsa.309261

Cited By: 3

Abstract

The
ligand 5-methyl-2-phenyl-4-[(E)-1,3-thiazol-2-yldiazenyl]-2,4-dihydro-3H-pyrazol-3-one
(Dy) has been synthesized by diazo coupling reactions of 5-methyl-2-phenyl-
2,4-dihydro-3H-pyrazol-3-one with 2-aminothiazole and ferric hydrogen sulfate
(FHS), as a catalyst, under solvent-free conditions. A series of complexes of
the ligand with Co(II), Ni(II), Cu(II), and Zn(II) ions are synthesized and
structurally characterized by 1H NMR, FTIR, and UV–Visible spectral techniques.
The cytotoxic activity of the complexes and the uncoordinated ligand against
human breast cancer (MCF-7) and chronic myelogenous leukemia cell line (human
erythroleukemia) (K-562) cell lines exhibits good viability in the range of
50.16–55.16% at a concentration of >100-110 µg/mL as compared to the
inhibition in the untreated cells. Further, the metal complexes and ligand were
screened against antibacterial strains of S. typhi, S. aureus, and E. coli.
Both the cytotoxicity and antioxidant studies are correlated with computational
docking analysis and powder XRD studies reviles that all complexes are in
crystalline nature.

Keywords

azo dye, solvent-free synthesis, ferric hydrogen sulfate, powder X-ray diffraction

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