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Bioactivity of Phaeophytin a, α-Amyrin and lupeol from Brachystelma togoense Schltr

Yıl 2019, Cilt: 6 Sayı: 3, 411 - 418, 20.10.2019
https://doi.org/10.18596/jotcsa.571770

Öz

Phaeophytin a, α-amyrin and
lupeol
isolated from Brachystelma togoense were
screened against S. aureus, E. coli, S.
pneumonia, S. typhi,
and C. albicans
using Ciprofloxacin and Terbinafine as standards.  The result showed that
these phytochemicals displayed antimicrobial activity against the tested
organisms with the zone of inhibition from 12 – 27 mm. The result of MIC showed
that
Phaeophytin a was most active against C. albicans (0.09
mg/ml)
. The MBC showed that phaeophytin a and lupeol were
the most active against

S. aureus, S. pneumonia
and S. typhi (0.37 mg/ml). The
result of MFC showed that

phaeophytin a was most active against C. albicans (0.1875
mg/ml).
 The
activity of
these phytoconstituents in B. togoense
justified ethnomedicinal uses of the plant. 

Destekleyen Kurum

TETFUND

Proje Numarası

2017 Academic Training

Teşekkür

Thanks

Kaynakça

  • 1. Höfling J, Anibal PC, Obando-Pereda G, A T Peixoto I, Furletti VF, Foglio M, et al. Antimicrobial potential of some plant extracts against Candida species. Brazilian Journal of Biology [Internet]. 2010;70:1065–8. Available from: http://www.scielo.br/pdf/bjb/v70n4/a22v70n4.pdf
  • 2. Yuan H, Ma Q, Ye L, Piao G. The Traditional Medicine and Modern Medicine from Natural Products. Molecules. 2016;21(229):1–3.
  • 3. Jamshidi-kia F, Lorigooini Z, Amini-khoei H. Medicinal plants : Past history and future perspective. Journal of Herbmed Pharmacology. 2018;7(1):1–7.
  • 4. Dar RA, Shahnawaz M, Qazi PH. General overview of medicinal plants : A review. The Journal of Phytopharmacology. 2017;6(6):349–51.
  • 5. Bruyns P V. Three New Species of Brachystelma (Apocynaceae, Asclepiadoideae, Ceropegieae) from South Tropical and Southern Africa. Vol. 19. SPIE; 2009. 5 p.
  • 6. Ollerton J, Masinde S, Meve U, Picker M, Whittington A. Fly pollination in Ceropegia (Apocynaceae: Asclepiadoideae): biogeographic and phylogenetic perspectives. Annals of Botany. 2009;103(9):1501–14.
  • 7. Britto SJ, Bruyns P V. Three new species of Brachystelma from Tamil Nadu, India. Haseltonia. 2016;(22):48–54.
  • 8. Kew Royal Botanical Gardens. Electronic Plant Information Centre (ePIC) [Internet]. 2019 [cited 2019 Feb 7]. Available from: http://epic.kew.org/index.htm
  • 9. Prasad K, Prasanna P V., Meve U, Rao MS, Thulasaiah T. Brachystelma annamacharyae sp. nov. (Apocynaceae) from the Seshachalam hills of Andhra Pradesh (India). Nordic Journal of Botany. 2016;34(3):360–3.
  • 10. Ekalu A, Ayo RG, Habila JD, Hamisu I. Phaeophytin and Triterpenoids from Brachystelma togoense Schltr , a Nigerian Medicinal Herb. Asian Journal of Chemical Sciences. 2019;6(1):1–5.
  • 11. Niaz SI, Zhang P, Shen H, Li J, Chen B, Chen S, et al. Two new isochromane derivatives penisochromanes A and B from ascidian-derived fungus Penicillium sp. 4829. Natural Product Research [Internet]. 2018;6419(May):1–7. Available from: https://doi.org/10.1080/14786419.2018.1470173
  • 12. CLSI. Testing, Clinical and Laboratory Standards Institute,32. 27 th. 2017.
  • 13. Gallo M, Miranda bullet, Sarachine J. Biological activities of lupeol. In: International Journal of Biomedical and Pharmaceutical Sciences. 2009. p. 46–66.
  • 14. Gomes RA, Teles YCF, Pereira F de O, Rodrigues LA de S, Lima E de O, Agra M de F, et al. Phytoconstituents from Sidastrum micranthum (A. St.-Hil.) Fryxell (Malvaceae) and antimicrobial activity of pheophytin a. Brazilian Journal of Pharmaceutical Sciences [Internet]. 2015;51:861–7. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000400861&nrm=iso
  • 15. Yen KH, Nyokat N, Kutoi CJ, Hamzah AS, Lim IF. Chemical Constituents of Artocarpus odoratissimus from Sarawak. 2017;7(08):137–41.
  • 16. Johann S, Soldi C, Lyon JP, Pizzolatti MG, Resende MA. Antifungal activity of the amyrin derivatives and in vitro inhibition of Candida albicans adhesion to human epithelial cells. 2007;45:148–53.
  • 17. Keawsa-ard S, Liawruangrath B, Kongtaweelert S. Bioactive Compounds from Mesua ferrea Stems. 2015;42(1):185–95.
  • 18. Díaz-ruiz G, Hernández-vázquez L, Luna H, Wacher-rodarte MC, Navarro-ocaña A. Growth Inhibition of Streptococcus from the Oral Cavity by α-Amyrin Esters. 2012;(Figure 1):12603–11.
  • 19. Kiplimo JJ, Koorbanally NA, Chenia H. Triterpenoids from Vernonia auriculifera Hiern exhibit antimicrobial activity. 2011;5(8):1150–6.
Yıl 2019, Cilt: 6 Sayı: 3, 411 - 418, 20.10.2019
https://doi.org/10.18596/jotcsa.571770

Öz

Proje Numarası

2017 Academic Training

Kaynakça

  • 1. Höfling J, Anibal PC, Obando-Pereda G, A T Peixoto I, Furletti VF, Foglio M, et al. Antimicrobial potential of some plant extracts against Candida species. Brazilian Journal of Biology [Internet]. 2010;70:1065–8. Available from: http://www.scielo.br/pdf/bjb/v70n4/a22v70n4.pdf
  • 2. Yuan H, Ma Q, Ye L, Piao G. The Traditional Medicine and Modern Medicine from Natural Products. Molecules. 2016;21(229):1–3.
  • 3. Jamshidi-kia F, Lorigooini Z, Amini-khoei H. Medicinal plants : Past history and future perspective. Journal of Herbmed Pharmacology. 2018;7(1):1–7.
  • 4. Dar RA, Shahnawaz M, Qazi PH. General overview of medicinal plants : A review. The Journal of Phytopharmacology. 2017;6(6):349–51.
  • 5. Bruyns P V. Three New Species of Brachystelma (Apocynaceae, Asclepiadoideae, Ceropegieae) from South Tropical and Southern Africa. Vol. 19. SPIE; 2009. 5 p.
  • 6. Ollerton J, Masinde S, Meve U, Picker M, Whittington A. Fly pollination in Ceropegia (Apocynaceae: Asclepiadoideae): biogeographic and phylogenetic perspectives. Annals of Botany. 2009;103(9):1501–14.
  • 7. Britto SJ, Bruyns P V. Three new species of Brachystelma from Tamil Nadu, India. Haseltonia. 2016;(22):48–54.
  • 8. Kew Royal Botanical Gardens. Electronic Plant Information Centre (ePIC) [Internet]. 2019 [cited 2019 Feb 7]. Available from: http://epic.kew.org/index.htm
  • 9. Prasad K, Prasanna P V., Meve U, Rao MS, Thulasaiah T. Brachystelma annamacharyae sp. nov. (Apocynaceae) from the Seshachalam hills of Andhra Pradesh (India). Nordic Journal of Botany. 2016;34(3):360–3.
  • 10. Ekalu A, Ayo RG, Habila JD, Hamisu I. Phaeophytin and Triterpenoids from Brachystelma togoense Schltr , a Nigerian Medicinal Herb. Asian Journal of Chemical Sciences. 2019;6(1):1–5.
  • 11. Niaz SI, Zhang P, Shen H, Li J, Chen B, Chen S, et al. Two new isochromane derivatives penisochromanes A and B from ascidian-derived fungus Penicillium sp. 4829. Natural Product Research [Internet]. 2018;6419(May):1–7. Available from: https://doi.org/10.1080/14786419.2018.1470173
  • 12. CLSI. Testing, Clinical and Laboratory Standards Institute,32. 27 th. 2017.
  • 13. Gallo M, Miranda bullet, Sarachine J. Biological activities of lupeol. In: International Journal of Biomedical and Pharmaceutical Sciences. 2009. p. 46–66.
  • 14. Gomes RA, Teles YCF, Pereira F de O, Rodrigues LA de S, Lima E de O, Agra M de F, et al. Phytoconstituents from Sidastrum micranthum (A. St.-Hil.) Fryxell (Malvaceae) and antimicrobial activity of pheophytin a. Brazilian Journal of Pharmaceutical Sciences [Internet]. 2015;51:861–7. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000400861&nrm=iso
  • 15. Yen KH, Nyokat N, Kutoi CJ, Hamzah AS, Lim IF. Chemical Constituents of Artocarpus odoratissimus from Sarawak. 2017;7(08):137–41.
  • 16. Johann S, Soldi C, Lyon JP, Pizzolatti MG, Resende MA. Antifungal activity of the amyrin derivatives and in vitro inhibition of Candida albicans adhesion to human epithelial cells. 2007;45:148–53.
  • 17. Keawsa-ard S, Liawruangrath B, Kongtaweelert S. Bioactive Compounds from Mesua ferrea Stems. 2015;42(1):185–95.
  • 18. Díaz-ruiz G, Hernández-vázquez L, Luna H, Wacher-rodarte MC, Navarro-ocaña A. Growth Inhibition of Streptococcus from the Oral Cavity by α-Amyrin Esters. 2012;(Figure 1):12603–11.
  • 19. Kiplimo JJ, Koorbanally NA, Chenia H. Triterpenoids from Vernonia auriculifera Hiern exhibit antimicrobial activity. 2011;5(8):1150–6.
Toplam 19 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Makaleler
Yazarlar

Abiche Ekalu 0000-0003-3343-1491

Rachael Gbekele-oluwa Ayo Bu kişi benim

James Habila Bu kişi benim 0000-0003-3518-5271

İbrahim Hamisu Bu kişi benim

Proje Numarası 2017 Academic Training
Yayımlanma Tarihi 20 Ekim 2019
Gönderilme Tarihi 30 Mayıs 2019
Kabul Tarihi 2 Ekim 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 6 Sayı: 3

Kaynak Göster

Vancouver Ekalu A, Gbekele-oluwa Ayo R, Habila J, Hamisu İ. Bioactivity of Phaeophytin a, α-Amyrin and lupeol from Brachystelma togoense Schltr. JOTCSA. 2019;6(3):411-8.