In this work, synthesis of novel 1,3,4-oxadiazole derivatives were reported. Good molecular properties profile was predicted for the target compounds. In drug likeness prediction, compound 4b and 8b possess the highest score of 0.31 and 0.33, respectively. Since the compounds have good bioactivity scores as kinase inhibitor, possible interactions of compounds with VEGFR-2 kinase and probable binding conformations were evaluated by molecular docking. All compounds formed hydrogen bonding interactions with Asp1046 amino acid of key residues.
Ankara University
Birincil Dil | İngilizce |
---|---|
Konular | Organik Kimya |
Bölüm | Makaleler |
Yazarlar | |
Yayımlanma Tarihi | 30 Ekim 2020 |
Gönderilme Tarihi | 18 Mart 2020 |
Kabul Tarihi | 20 Temmuz 2020 |
Yayımlandığı Sayı | Yıl 2020 Cilt: 7 Sayı: 3 |